Fig. 2

KIRCLE accuracy and consistency validation. a Contour plot demonstrating the effect of varying the bootstrap-proportion (p) and threshold (t) hyperparameters on KIR2DL1 allele inference, as measured by empirical calculation of the inferred genotypes’ entropy. b KIRCLE’s performance on KIR2DL4 allele inference was similarly characterized. c Fraction of each KIR gene’s KIRCLE-inferred allele genotypes that were called identically between 531 samples and their biological replicates in TCGA. Error bars represent the normal approximation confidence intervals. d TCGA sample coverages (binned) versus TCGA sample allele probability entropies for all 15 KIR genes. The allele probability entropies of a set of 20 “pseudo-BAMs” (green) are presented as negative controls