Fig. 8
Mechanistic gene expression alterations in human endometriomas. A Left, enrichment for ARID1A-H3.3 co-repressive chromatin mechanistic gene sets among human endometrioma (ovarian endometriosis) vs. control endometrium DE genes reported by Hawkins et al. [53], compared to all unique measured genes. Right, proportion of overlapping DE genes that are upregulated vs. downregulated in endometriomas, compared to all unique measured genes. Statistic is hypergeometric enrichment. B Box plots displaying endometrioma expression log2FC values for probes annotated to genes within mechanistic gene sets, compared to all measured probes. Statistic is two-tailed, unpaired Wilcoxon’s test. C Relative expression box-dot plots of 6 genes upregulated in endometriomas vs. control endometrium that are co-repressed by ARID1A, H3.3, CHD4, and ZMYND8. Statistic is limma FDR-adjusted p. * p < 0.05, ** p < 0.01, *** p < 0.001