Fig. 5

Downregulation of E2F targets in the AF1_FFF uterus on GD4.5 is associated with reduced stromal cell proliferation. A Seven of the top 10 TFTs enriched in the WT are E2F targets (FDR < 0.25). B The core enriched E2F target genes were all downregulated in the AF1_FFF uterus. The graph is plotted with transcript reads of each gene (mean ± SEM, n = 4, padj < 0.05). C The AF1_FFF stromal tissue shows fewer Ki67-positive cells than the WT. The images are representative of four samples in each genotype. The region in the black rectangle is enlarged to show clearer Ki67 staining in the insets