Fig. 3

Metabolite genome-wide association studies (mGWAS) and candidate gene functions. A Number of the most significantly associated single nucleotide polymorphisms (SNP) and proportion of significantly associated SNPs. B Distance to the closest gene and association −log10(p) values of the most significantly associated SNP for each metabolite marker. The dotted red line delimits 75% of the SNPs. Number of genome-wide SNP closest to gene. Proportion of SNPs found per gene element across the genome and for the significantly SNPs. C Gene ontology term enrichment analysis of functions encoded by the closest genes. D Number of the most significantly associated SNP to the closest gene based on gene type, biosynthetic gene cluster class and function. *, **** : p-value <0.05, <0.00001, respectively