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Fig. 5 | BMC Biology

Fig. 5

From: SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

Fig. 5

Transcriptional target analysis for the SMYD3/NuRD complex. a LM3 cells were transfected with control siRNA, SMYD3 siRNA, MTA1 siRNA, or MTA2 siRNA followed by RNA extraction and deep sequencing. Three independent samples were used for the RNA-seq analysis. mRNA expression data were clustered using Cluster 3.0 software. b Intersection of SMYD3-, MTA1-, and MTA2-regulated transcriptomes revealed 262 coregulated genes with a fold change ≥ 2. c, d KEGG pathways enrichment analysis and GO analysis of the co-target genes of SMYD3, MTA1, and MTA2 were performed to further explore the function of the SMYD3/NuRD(MTA1/MTA2) complex. e GSEA results showing enrichment gene signatures related to Wnt β-catenin signaling pathway and Notch signaling pathway in LM3 cells in response to SMYD3, MTA1, or MTA2 knockdown

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BMC Biology

ISSN: 1741-7007

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