Table 1 Maximal efficacies (Emax) and potencies (EC50) of MRS2179, MRS2279 and MRS2500 on P2Y1-R-dependent Gαq protein activation and β-arrestin 2 recruitment
From: Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment
G protein signaling | |||
Emax ± s.e.m. | EC50 (M) | pEC50 ± s.e.m. | |
MRS2179 | 115.7 ± 5.057 | 1.525e−005 | 4.817 ± 0.0671 |
MRS2279 | 154.3 ± 13.86 | 2.638e−005 | 4.579 ± 0.1247 |
MRS2500 | 127.2 ± 3.892 | 7.716e−007 | 6.113 ± 0.07237 |
β-Arrestin 2 signaling | |||
Emax ± s.e.m | EC50 (M) | pEC50 ± s.e.m | |
MRS2179 | − 103.3 ± 6.549 | 5.055e−006 | 5.296 ± 0.153 |
MRS2279 | − 102.8 ± 14.98 | 1.943e−005 | 4.712 ± 0.2838 |
MRS2500 | − 89.95 ± 2.887 | 4.755e−008 | 7.323 ± 0.1193 |