Fig. 7

UMAP of the chromatin landscape defines chromatin states. A UMAP of the chromatin of female day 6 gametocytes, divided in bins of 50 bp, coloured by their individual chromatin states. B UMAP of female day 6 gametocytes coloured by ring stage chromatin states, showing conserved and remodelled bins. C Pie charts of the distribution of chromatin states over different genetic elements per parasite stage. D Violin plots showing the FPKM values of the genes that carried a region of at least 300 bp of the different states in their 2 kb upstream region in female day 6 gametocytes and ring stage parasites, respectively, indicated by the parasite stage above the plot. The FPKM values are compared between gametocyte gene expression (D6F), ring stage gene expression (R) and schizont stage gene expression (S) on the x-axis. Differences between the groups were investigated using Wilcoxon rank sum test with continuity correction (* p < 0.05, ** p < 0.01, *** p < 0.001). The black line represents the mean FPKM value