Fig. 8

Chromatin states are linked to differential gene expression across parasite stages. The line plots show the log₂-transformed ChIP/Input coverage of the different histone modifications in the 2 kb upstream region, gene body (ATG to STOP) and 2 kb downstream region in rings, schizonts and day 6 female gametocytes. Heatmaps show the relative expression (FPKM z-scored) of the same groups in rings (R), schizonts (S), and female day 6 gametocytes (G). Gene lists were defined by genes of this group that had a defined chromatin state in rings, resulting in 53 cell cycle genes, 41 IMC genes and 55 invasion genes. A) Genes involved in cell cycle. B) Genes of the inner membrane complex (IMC). C) Genes involved in invasion. The chromatin states observed in each panel are indicated