Fig. 1

Sequence similarity between promoters of paralogs in human and mouse genomes. A Sequence similarity scores between promoter regions of human paralogs, where paralogs are partitioned based on their inferred duplication time (at each TMRCA (time to most recent common ancestor) from Opisthokonta to Homo Sapiens). In each group of paralogs belonging to the same TMRCA, the distribution of similarity scores is compared to that of randomly matched set of human gene promoters. Comparison between the distributions was preformed using a Mann–Whitney one-sided test and corrected by FDR. B As in A, only with mouse paralogs. C As in A, but with partitioning of paralogs based on their dS values (synonymous substitution rate between paralogs). Paralogs are binned into equal-sized bins. Left-most bins represent the highest dS values, and likely the oldest duplicates, while right-most bins represent lowest dS values. D as in C, only with mouse paralogs. (***P < 0.001, **P < 0.01, *P < 0.05). Group size numbers appear in Additional File 2: Table 1