Fig. 5

CGI and CGI-less genes duplication over evolutionary time. A A timeline showing the relative fractions of human paralogs at each TMRCA from Opisthokonta to Homo Sapiens, where each point is split into CGI paralogs, CGI-less paralogs, and Mixed paralogs. B The same as in A, only with mouse paralogs. CGI and Mixed pairs are skewed towards ancient times of duplication in both human and mouse paralogs (permutation test, P-value < 10 − 5). C,D Distributions of P-values of rates of gain and loss in CGI and CGI-less genes in human and mouse. Comparison between the distributions was preformed using a Mann–Whitney one-sided test. Group size numbers are as in Fig. 1A,B