Table 1 Characteristics of osteosarcoma models used in this study
Model | Species | Type | Host | Endpoint | Characteristics |
|---|---|---|---|---|---|
OS-17 | Human | Cell Line | Icr-scid | 70 days | Low passage, very well-characterized, reliable metastases |
143B | Human | Cell Line | Icr-scid | 65 days | Widely utilized, very well-characterized, reliable metastases |
NCH-OS-2 | Human | PDX | Icr-scid | 200 days | Very low-passage, highly penetrant, from an untreated synchronous metastasis |
NCH-OS-7 | Human | PDX | Icr-scid | 184 days | Very low-passage, highly penetrant, from a heavily-pretreated, multiply-relapsed metastasis |