Fig. 5From: Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafishWorking models of NgAgo-gDNA repression of transcription and NgAgo-VP64 activation of transcription. Upon NgAgo-gDNA binding to a gene, RNA polymerase progression is blocked, reducing the transcript level of the targeted gene. Recruitment of RNA polymerase by four tandem VP16s (VP64) fused to NgAgo can be used to activate target gene expressionBack to article page