Fig. 2

TRPM4 contributes to intrinsic electrophysiological properties of MCs. A Left, overlay of APs from WT (black) and Trpm4^−/− (red) MCs induced by current injection. Amplitudes of the representative APs are normalized to each other for better visibility. Right, statistics of AHPs from WT and Trpm4^−/− MCs. n = 17 for WT and 13 for Trpm4^−/−. B Left, representative traces of EPSPs from WT and Trpm4^−/− MCs. Right, statistics of sEPSP from WT and Trpm4^−/− MCs. n = 19 for WT and 21 for Trpm4^−/−. C Left, representative spontaneous APs from WT and Trpm4^−/− MCs. Right, statistics of AP frequency from WT and Trpm4^−/− MCs. n = 20 for WT and 19 for Trpm4^−/−. D Left, representative current clamp recordings from WT and Trpm4^−/− MCs upon 1 mM glutamate application. Right, statistics showing the percentage of neurons in depolarization block. n = 7 for WT and 6 for Trpm4^−/−. E Left, representative spontaneous APs from WT MCs in ctrl condition, upon application of 9-phenanthrol and after wash out of the drug. Right, statistics showing AP frequency from WT MCs during the three mentioned conditions n = 9. *p < 0.05, **p < 0.01