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Fig. 3 | BMC Biology

Fig. 3

From: Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy

Fig. 3

Evolution trajectory and transcriptional fluctuation during tendinopathy progression. A Cell trajectory analysis of TSPC differentiation in the normal tendon. B Cell trajectory analysis of TSPC differentiation in the diseased tendon. C Heatmap showing the expression changes of the highly variable genes along the two cell fates of the trajectory in the normal group. Significantly enriched functional annotations are shown on the right side of the heatmap. D Heatmap showing the expression changes of the highly variable genes along the two cell fates of the trajectory in the diseased group. E, F Representative gene expression levels of different marker genes along TSPC differentiation trajectories of normal and diseased statuses. G, H Immunohistochemical staining of EGR1 and COMP in the normal tendon. I, J Immunohistochemical staining of SOX5 and COL10A1 in a lesioned tendon

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BMC Biology

ISSN: 1741-7007

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