Fig. 4

Differential exon methylation affected splicing conditional upon exon accessibility and genic architecture. A Differential exon use in response to maternal upwelling is plotted against exon differential methylation. Rows and columns group data based on total genic intron length and exon accessibility quartiles. First and last rows/columns denote highest and lowest quartiles while the middle row/column denote second and third quartiles. B Log-scale inclusion Bayes factors depicting the probability of observed data under models fitting a parameter relative to those without it, including the interaction effect visualized in A. For parameters listed on the y-axis, “methylation” = exon differential methylation, “chromatin” = exon accessibility, and “architecture” = total genic intron length. n = 12 RNA-seq and RRBS replicate libraries; n = 3 ATAC-seq replicate libraries