Fig. 5

Effect of dopamine on the retinal clock in the absence of melanopsin. Means of the endogenous period and the phase of P8 and P30 retinal explants from Opn4 ^−/− ::Per2 ^Luc mice, supplemented with DA (50 and 100 µM) and compared to non-supplemented control retinas. The total numbers of Opn4 ^−/− ::Per2 ^Luc retinas used were: P8: C, n = 6; DA 50 µM, n = 4; DA 100 µM, n = 4. P30: C, n = 5; DA 50 µM, n = 5. Data from wild-type retinas are already presented in Fig. 1C. Bars represent mean ± SEM (ANOVA, ** = p ≤ 0.01)