Fig. 4
From: Regulation of mouse exploratory behaviour by irradiance and cone-opponent signals
Light steps enriched for long versus short wavelength sensitive cone stimulation differentially activate the ventral supraventricular zone. A Representative images of c-Fos immunolabelled hypothalamic hemi-sections from Opn1mw.R mice following 30 min, rod and melanopsin-isoluminant and cone illuminance matched light pulses biased towards L-opsin (‘Yellow’) or S-opsin (‘Blue’) stimulation (Additional file 1: Fig. S3A, spectra 3 and 4), delivered at projected ZT 17.5. B Average maps of c-Fos expression density for ‘Yellow’ and ‘Blue’ light pulses (n = 6 mice/group). C Spatial map of the mean difference in c-Fos expression density for ‘Yellow’ and ‘Blue’ light pulses (derived from data in B). D Higher magnification view of c-Fos expression in the SCN and SPZ from A. E–G Mean ± SEM density of c-FOs expression cells in SCN (E), SPZ (F) and NRe (G) for ‘Yellow’ and ‘Blue’ light pulses (n = 6/group). Data analyses by unpaired t-test. * = P < 0.05, ns = P > 0.05