Fig. 6
From: Regulation of mouse exploratory behaviour by irradiance and cone-opponent signals
Cone-opponent regulation of subparaventricular zone network activity. A–C Representative single neuron responses (top; same cells as Fig. 5A–C) and mean ± SEM normalised population responses (bottom; n = 5, 21 and 20 respectively in A–C) for the identified classes of SPZ neurons in response to 60 s, 1 log unit, light steps selectively targeting one or both cone opsin types (S + , L + and L + S +) or all opsins equally (All +). See Additional file 2 for underlying raw data. D Mean ± SEM multiunit activity (MUA) traces (top) and stimulus-evoked changes in firing (bottom) across supraventricular zone (SPZ) recording sites (n = 128) for the same stimuli in A–C. E Mean ± SEM normalised MUA response to light steps targeting S- or L-cone opsins (left) or for both cone opsins with or without changes in brightness for melanopsin and rods (right) as a function of recording site depth within the SPZ (n = 8–26 sites/bin). Data in A-D analysed by one-way RM ANOVA with Tukey’s post tests (A: F3, 12 = 12.4, P = 0.0006; B: F3, 60 = 525.7, P < 0.0001; C: F3, 57 = 15.4, P < 0.0001; D: F3, 381 = 29.4, P < 0.0001). Data in E analysed by 2-way mixed effects ANOVA (left- Stim.: F1,240 = 216.3, P < 0.0001; position—F11,240 = 0.84, P = 0.596; Stim. X position—F11,240 = 0.99, P = 0.459; right—Stim.: F1,240 = 118, P < 0.0001; position-F11, 240 = 0.803, P = 0.637; Stim. X position-F11,240 = 1.05, P = 0.403). *,** and *** indicate P < 0.05, P < 0.01 and P < 0001, respectively