Fig. 8
Historical change in monitoring of A behavioral parameters, B physiological parameters, and C external appearance-related parameters in mice and rats in their home cages (data obtained from n = 520 publications). More than one application (i.e., parameter) could be indicated in a publication. If the same parameter was investigated using different techniques in a study, the parameter was counted only once for this study. Examples for abnormal behaviors were infanticide, barbering, and stereotypy. Other behaviors (each n = 1): sneezing, sign of pain or distress (not further specified), clinical signs (not further specified), curiosity/alertness, champing behavior, twitches, and behavior not further specified. Note the differences in the scaling of the y-axis