Fig. 5
From: Circulating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis
Distinct characteristics in cancer patients. A Concentration of cfDNA in plasma in 438 cancer patients and 901 healthy individuals. B The size distribution of cfDNA was inferred by paired-end sequencing of plasma samples from cancer patients and healthy individuals. C Scatter plot of the ratio of P50, P60, P70, P81, P91, P102, P111, P122, P134, P144, and P153 from cancer patients and healthy individuals. ns: not significant, **P < 0.01, ***P < 0.001, ****P < 0.0001 (U-test). D Line plots show the ratio of reads falling into each peak ± 1 bp ranges of eleven periodic peaks (50, 60, 70, 81, 91, 102, 111, 122, 134, 144, and 153 bp) from cancer patients and healthy individuals. E Violin plots of the percentage of the cfDNA fragments of different sizes with C-end in cancer patients and healthy subjects. Statistical significance of the decreased C-end preference in cancer patients was evaluated by paired t-test (***p < 0.001)