Fig. 1
From: Geroprotector drugs and exercise: friends or foes on healthy longevity?
Capitalizing on the combination of regular exercise and geroprotectors. Current dogma suggests combining geroprotectors with concurrent exercise blunts hallmarks of exercise that are associated with healthy longevity. Frequent (daily) dosing of leading geroprotectors blunts clinically relevant improvements to cardiorespiratory fitness, muscle size/strength/power, and insulin sensitivity. Along the aging continuum, identifying an appropriate age to begin intervening with combined approaches represents an opportunity to suppress the age-related decline in systemic health. Finally, manipulating dose or frequency of dosing may provide the opportunity to capitalize on the benefits of both regular exercise and geroprotectors to enhance healthy longevity to new heights. Created with BioRender.com