Fig. 2
From: DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
Polθ promotes small deletions of chromosomal rearrangements. Significant decreases of small deletions and increases of precise ligations at the upstream (A, E) and downstream (B, F) junctions of DNA-fragment inversions as well as at the junctions of DNA-fragment deletions (C, G) and duplications (D, H) upon knockdown of PolQ (encoding Polθ polymerase) (see Additional file 5: Table S3, n = 3 replicates, mean ± SEM). I Estimation of the probability of MMEJ with increasing deletion size