Fig. 7

Increased tau aggregation correlates with reduced DNAJB6 expression in an age-dependent manner in a mouse model of tau pathology. A–D Immunohistochemistry staining was conducted in the coronal sections of the wild-type (A and C) and rTg4510 (B and D) mice. The coronal slices were at the level Bregma -2.06 mm. Representative images display the DNAJB6 (red), AT8 (green), and DAPI (blue) stainings throughout the hippocampal region (top) and in the CA1 and CA3 regions of the hippocampal neurons (bottom) in rTg4510 mice and non-transgenic littermate controls at the age of 3 (A-B) and 6.5 months (C-D). E Quantitative analysis of expression of DNAJB6 and AT8 in CA1 and CA3 regions of rTg4510 mice and littermate controls at the age of 3 and 6.5 months (n = 3, *P < 0.05, **P < 0.01, two-tailed Student’s t-test). The individual data values of the replicates in E are listed in Additional file 2