Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis

Table 1 Frequency of mushroom body defects resulting from pan-neuronal expression of HDAC4^WT and mutants

Genotype	n	Total β lobe fusion (%)	β lobe fusion and thin or absent lobe(s) (%)	Severe β lobe fusion (%)	Moderate β lobe fusion (%)	Minor β lobe fusion (%)	Thin or absent lobe(s) (%)	No defects (%)
elav/ +	19	0	0	0	0	0	0	100
elav/ + ;UAS-HDAC4^WT/ +	33	88	21	67	0	0	12	0
elav/ + ;UAS-HDAC4^3SA/ +	20	95	45	50	0	0	5	0
elav/ + ;UAS-HDAC4^ΔMEF2/ +	19	5	0	0	0	5	0	95
elav/ + ;UAS-HDAC4^ΔNLS/ +	19	79	37	26	11	5	0	21
elav/ + ;UAS-HDAC4^ΔANK/ +	18	100	61	33	6	0	0	0
elav/ + ;UAS-HDAC4^Y1142H/ +	20	95	0	65	30	0	5	0

The percentage of brains displaying a single phenotype of severe, moderate or minor β lobe fusion, or thin/absent lobe(s) is shown. As a measure of severity of the phenotype, the percentage of brains displaying both β lobe fusion and thin or absent lobes is also shown. The total percentage of brains displaying β lobe fusion is also calculated by combining minor, moderate and severe β lobe fusion, and those brains with both β lobe fusion and thin or absent lobes. elav = elav-GAL4

ISSN: 1741-7007