Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis

Table 4 Co-expression of CG5846 does not alter the mushroom body defects induced by expression of HDAC4^WT or HDAC4^ΔANK

Genotype	n	Total β lobe fusion (%)	β lobe fusion and thin or absent lobe(s) (%)	Severe β lobe fusion (%)	Moderate β lobe fusion (%)	Minor β lobe fusion (%)	Thin or absent lobe(s) (%)	No defects (%)
elav/ +	20	0	0	0	0	0	0	100
elav/ + ;UAS-CG5846/ +	20	0	0	0	0	0	0	100
elav/ + ;UAS-HDAC4^WT/ +	20	90	5	50	15	20	10	0
elav/ + ;UAS-CG5846/ + ;UAS-HDAC4^WT	20	90	0	75	10	5	5	5
elav/ + ;UAS-HDAC4^ΔANK/ +	20	75	25	35	10	5	25	0
elav/ + ;UAS-CG5846/ + ;UAS-HDAC4^ΔANK	20	95	30	55	10	0	5	0

The percentage of brains displaying a single phenotype of severe, moderate or minor β lobe fusion, or thin/absent lobe(s) is shown. Flies were raised at 23 °C. As a measure of severity of the phenotype, the percentage of brains displaying both β lobe fusion and thin or absent lobes is also shown. The total percentage of brains diplaying β lobe fusion is also calculated by combining minor, moderate and severe β lobe fusion, and those brains with both β lobe fusion and thin or absent lobes. elav = elav-GAL4

ISSN: 1741-7007