Fig. 1

G4s are forming within the TMPRSS2 gene. a Schematic illustration of the TMPRSS2 gene and the location of the four G4 motifs identified by G4 Hunter [36]. b Circular dichroism of the selected oligonucleotide harboring G4s. In the four panels, the absorbance was calculated in a range between 220 and 330 nm. The black lanes are representative of the original sequence, gray or light gray lanes represent oligonucleotide with mutations in order to disrupt the G4 motifs. c NMM (left panel) and ThT (right panel) staining of the selected oligonucleotide harboring G4s, run in a 15% TBE native gels