Fig. 5
From: TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Model. PDS and CX-5461 treatments stabilize G4s in the promoter and gene body inducing a partial downregulation of the TMPRSS2 mRNA, especially of the isoform 1. Furthermore, G4 stabilizers treatment induces stabilization of the G4 in the 5´-UTR (exon 1) of the isoform 1 with a consequent downregulation of the TMPRSS2 isoform 1 protein. TMPRSS2 isoform 1 downregulation will be crucial for inhibiting the replication of the already internalized SARS-CoV-2 replicon