Fig. 2

Accurate and increasingly refined estimation of cellular composition of the cortex from DNA methylation profiles. Violin plots of the error, measured by the CETYGO score, associated with estimating the cellular proportions of reconstructed cortical brain profiles. Panels represent different combinations of nuclei populations, as defined in Table 1, with reconstructed cortical profiles generate to capture the full spectrum of cellular heterogeneity (n = 90–1260). For reference panels with more than two cell types, two methods were used to select the cell-specific sites that serve as the basis for the algorithm represented by different violins