Fig. 2

Differential and similar chromatin-accessible regions (DARs and SARs) properties. A Distribution of DARs (blue, left) and SARs (red, right) relative to the TSS of DEGs (blue heatmap) and SEGs (red heatmap) in 5-kB bins. Heat maps show occurrences of DARs/SARs around each gene TSS. B Pie chart of genome-wide distribution of DARs and SARs. C Clustering of matched DARs (blue line, left heat map) around lineage-specific H3K27ac enhancers (green heatmaps), and SARs (red line, right heatmap) around H3K27ac for comparison. D (left) Distribution of DARs (blue line) around H3K4me3 peaks (violet heatmap); (right) distribution of SARs (red line) around H3K4me3 peaks (violet heatmaps). E An example of SEG-populated TAD and SARs within it, with SARs aligned with SEG gene’s promoters for 15 of the 16 promoters