Fig. 5

Inferring lineage-specific sets of driver TFs. A The upset plot for significantly enriched motifs (p < 0.001) within lineage-specific putative enhancers. Colours are for lineage-specific lists: green for ectoderm, blue for endoderm, pink for mesoderm. B TFs binding to lineage-specific enhancers: their TFBS motifs are most enriched (p < 0.001) within DEG’s lineage-specific putative enhancers, filtered by GE > 0 of their corresponding genes. The genes are expressed in their lineage and the corresponding motif is enriched in the lineage-specific regulatory regions. C Green, blue, pink coloured boxes within circles (DEGs) at the top contain pioneer driver DEG-produced TFs. The orange-rimmed boxes contain lineage-specific binding TFs (correspondingly coloured background), presumably cooperative TFs; their genes are expressed in all three lineages (SEGs). Coloured ovals denote distal putative enhancers with cis-regulatory motifs for corresponding TFs