- Open Access
What does the concept of the stem cell niche really mean today?
© Lander et al; licensee BioMed Central Ltd. 2012
Received: 2 March 2012
Accepted: 9 March 2012
Published: 9 March 2012
The richness of niche-ness - an introduction
Arthur D Lander
Ideas about stem cells, and how they behave, have been undergoing a lot of change in recent years, thanks to developments in visualizing, monitoring, and manipulating cells and tissues. Curious to find out what impact these changes are having on one of the most enduring and widely accepted metaphors in stem cell biology - the idea of the stem cell niche - BMC Biology asked researchers working on a variety of systems to write about their current conception of what a stem cell niche really is.
The answers presented below suggest that the detailed mechanisms underlying niche function are extremely varied. Niches may be composed of cells, or cells together with extracellular structures such as the extracellular matrix (ECM). They may be sources of secreted or cell surface factors - including members of the Notch, Wnt, fibroblast growth factor (FGF), epidermal growth factor (EGF), transforming growth factor (TGF)-β, stem cell factor (SCF), and chemokine families - that control stem cell renewal, maintenance, or survival. They may consist of just a single cell type, or a whole host of interacting cells. They may derive from cells outside the stem cell's lineage, or they may derive primarily from the stem cell's own descendents. In general, there seems to be much more consensus about the fact that stem cells invariably need niches than about the specific mechanisms by which niches do their jobs.
Why should a stem cell need a special environment? This is a pertinent question, given that none of the elementary processes that stem cells rely upon - growing, dividing, differentiating - are unique to stem cells. We can easily imagine three classes of answers:
One possibility is that there are demands placed on stem cells that necessitate special support for viability. For example, the need, imposed by cellular immortality, to minimize the accumulation of genetic damage, may drive stem cells to adopt a peculiar metabolic state that might force them to rely upon other cells nearby for sustenance. This 'nutritive' function of the niche remains a formal possibility, but in most systems few experimental data in support of it have so far emerged.
A second possibility is that niches are agents of feedback control. Recent studies tell us that stem cell pools are not slavishly maintained at a constant size by fixed, asymmetric divisions, but are usually capable of expanding or contracting and, even under homeostatic conditions, may face large stochastic fluctuations. The varied growth factors and cell surface molecules produced by niche cells may share the common goal of controlling stem cell pools. If this is the case, then the niche might best be thought of not simply as an environment conducive to stem cell functioning, but as an apparatus for communicating information about the state of a tissue back to the stem cells that maintain it. An important question to address would then be how niches obtain and relay such information.
A third possibility is that niches are instruments of coordination among tissue compartments. Some of the best evidence for this view comes from work on the hair follicle niche, described below by Elaine Fuchs. There, stem and progenitor cells responsible for maintenance of epidermis, pigmentation, hair, and connective and adipose tissue all interact in close proximity. A need to achieve tight coordination among these different cell populations may be the overriding reason for complex organization of this niche. The possibility that other niches may also be hubs of inter-lineage coordination is certainly an idea worth investigating.
The C. elegans distal tip cell and the concept of a stem cell niche
The molecular circuitry underlying DTC regulation of GSC maintenance provides the basis for a molecular definition of the niche. Briefly, the DTC uses a signaling pathway that is broadly conserved among metazoans, known as Notch signaling, to regulate GSC maintenance; GSCs respond to Notch signaling via an elaborate network of mRNA and cell cycle regulators (Figure 1c) [8, 9]. A major hub of this network is FBF, which is crucial for GSC self-renewal; FBF is a sequence-specific PUF (for Pumilio and FBF) RNA-binding protein and broad-spectrum repressor of differentiation (for example, [10–12]). This FBF hub may reflect the existence of either a fundamental mechanism that acts in many types of stem cells or a specialized mechanism that acts primarily in GSCs to protect their totipotency. A signature of this network is a pervasive redundancy that made the circuitry challenging to unravel experimentally, but renders GSC decisions (self-renewal versus differentiation) highly robust and regulatable [9, 10]. So how is the niche defined in molecular terms? A minimalist view is that the DTC membrane presenting Notch ligands to adjacent GSCs defines the niche (Figure 1c, dark red). A broader view includes the DTC itself as integral to the continuous Notch signaling at its surface (Figure 1c, pink).
Investigations of the DTC and Notch signaling have expanded our notion of what a stem cell niche can do. Normally germ cells mature in a gradient, with GSCs at the distal end, differentiated gametes at the proximal end and progressively maturing germ cells in between (Figure 1d). The DTC and Notch signaling establish and maintain that pattern of maturation [2, 13], and also regulate formation of normal oocytes at the proximal end of the tissue . Therefore, the influence of the niche extends beyond stem cell control to include the regulation of tissue organization and function.
Investigations of the DTC and Notch signaling also provide insights into the developmental generation of a niche, a process essential for stem cell regulation. The DTC arises from an asymmetric cell division , and the Wnt signaling pathway and CEH-22/Nkx2.5 transcription factor specify its niche properties [16, 17]. Manipulation of the Wnt pathway and CEH-22 can direct formation of ectopic niches, ectopic GSCs and ectopic maturation gradients [16, 17]. In addition, a 'latent niche' was revealed when immature germ cells aberrantly came into contact with non-DTC cells expressing Notch ligands (Figure 1d) . Such a latent niche drives formation of a germline tumor, perhaps because its geometry interferes with the movement of GSC progeny out of the niche.
The intestinal crypt niche
A minimal definition of an adult stem cell involves only two criteria: 1) an adult stem cell persists for the lifetime of the animal ('longevity'); and 2) an adult stem cell can make all cell types of the tissue to which it belongs ('multipotency'). Adult stem cells typically depend on a close interaction with a dedicated cellular environment, the so-called niche. While it has been possible to study invertebrate stem cells and their niches with single-cell resolution, the size of mammalian tissues combined with the infrequent occurrence of stem cells have complicated the identification of individual stem cells in vivo . The epithelium of the mammalian small intestine presents a prototypic example of the hierarchical organization of stem cell-driven, self-renewing tissues. A limited number of stem cells reside at the crypt base. Each of these stem cells divides once per day . Daughter cells can exit the stem cell compartment into the transit amplifying (TA) compartment. TA cells undergo approximately four to five rounds of division approximately every 12 hours, an unusually short duration . TA cells differentiate into differentiated cell types, such as enterocytes, goblet cells and enteroendocrine cells, which continue to move up the flanks of the villi. Upon reaching the villus tip after two to three more days, the differentiated cells undergo apoptosis. A fourth cell type, the Paneth cell, also derives from the stem cells, but migrates downwards and settles at the crypt base to live for four to six weeks .
Lgr5 stem cells are closely associated with Paneth cells in vivo and in vitro. Paneth cells are known to produce bactericidal products, but they also make EGF, TGF-α, Wnt3 and the Notch ligand Dll4, the essential components of the mini-gut culture system . While single sorted stem cells grow inefficiently in culture, stem cell/Paneth cell doublets robustly generate mini-guts. In vivo, genetic removal of Paneth cells results in the concomitant loss of Lgr5 stem cells. Thus, Paneth cells, daughters of Lgr5 stem cells, provide essential stem cell niche signals.
The hair follicle stem cell niche
Stem cells reside in specialized microenvironments, known as 'niches' . Cellular components of the niche participate importantly in governing stem cell behaviors, ranging from dormancy and activation to migration and differentiation. Until recently, the niche components impacting on stemness were assumed to derive from heterologous cell types of non-stem cell lineages. Unexpectedly, however, increasing evidence from both invertebrates and vertebrates has begun to broaden this view to include stem cell progeny themselves as important niche components that regulate stem cell activity and behavior.
The skin is the largest organ, and its enormous need for tissue regeneration makes it the most abundant source of stem cells of our body. Hair follicles of the skin are unique in that they undergo synchronized, cyclical bouts of tissue regeneration beginning with a phase in which the hair grows out, followed by a destructive phase in which the hair stops growing and the lower two-thirds of the follicle degenerates. The destructive phase is followed by a period of rest, after which the cycle begins anew. As such, the hair follicle stem cells, which fuel this tissue regeneration, undergo extended periods of rest, and are only briefly activated at the beginning of each hair cycle . Given the beauty of this system, the hair follicle has emerged as an important paradigm to study stem cells in quiescence and in action.
An unusual feature of the hair follicle stem cell niche is that one of its key stimulatory components is transient. The dermal papilla is a cluster of specialized mesenchymal cells that rests adjacent to the bulge niche during the resting phase of the hair cycle, but moves downward with the committed proliferative progenitors following transition to the growing phase. During the dormant phase, crosstalk between the dermal papilla and the hair follicle stem cells contributes to the threshold of activating cues (Wnts, bone morphogenetic protein (BMP) inhibitors and TGF-βs) necessary to shift the stem cells from a quiescent to an activated state [36–45].
Another facet of the hair follicle involves the molecular brakes that put its stem cells back into quiescence following an active period of tissue regeneration. In the past year, it was discovered that as hair follicle stem cells progress along their lineages and near completion of the active production of the hair and its channel, some of the terminally differentiated progeny midstream along the lineage wind up back in the bulge. There, they reside in the inner layer that is sandwiched between the outer layer of hair follicle stem cells and the inner core that contains the hair shaft. These invading progeny have lost their potential for stemness and do not regain it even upon wounding. However, they contribute heavily to the niche by transmitting potent BMP and FGF signals that maintain stem cells in a quiescent state  (Figure 4b). To reactivate the hair cycle, activating cues must overcome the inhibitory inputs. Compounding these localized niche signals, the balance is also influenced by waves of macro-environmental signals emanating from the dermal adipose tissue [47–49]. These long-range signals help to synchronize the stem cell niches in the hair coat.
Overall, the ease of working with the hair follicle stem cell niche, the abundance of its stem cells, and the synchronized bouts of natural tissue regeneration have catapulted this system to a prominent position in niche research. The complexity of its niche signals and the diversity of stem cells within this niche will keep the field occupied for the decade to come.
Skeletal muscle: the satellite cell niche
Didier Montarras and Margaret Buckingham
The repair of adult skeletal muscle depends on muscle satellite cells, which, when activated upon injury, will proliferate and then differentiate to make new muscle fibers, or, after self-renewal, re-constitute the reserve of muscle progenitors. The satellite cell therefore displays properties of a tissue-specific stem cell . In normal adult muscle, it is localized as a 'satellite' in close association with the muscle fiber , under the basal lamina, which separates individual fibers from the interstitial space. This is the niche of the quiescent satellite cell. There is as yet no clear evidence that the fiber itself regulates the positioning of the satellite cell. Myonuclei lie on the periphery of the contractile apparatus, which occupies the central core of the fiber, although they are spaced along the fiber without obvious synchronization in relation to satellite cells. The fiber is contacted by tendons and nerves and it has been proposed that there is a relationship between myoneural junctions and satellite cell density , but this requires further investigation. The interstitial space is mainly occupied by a heterogeneous population of connective tissue cells and blood vessels and there is accumulating evidence that vascularization influences the satellite cell niche . A remarkable feature of skeletal muscle is that the number of satellite cells per fiber does not vary for a given fiber type and is precisely reconstituted after regeneration. Between fiber types this fixed number is different, with a four-fold increase in satellite cells for slow oxidative ('slow twitch') compared to fast glycolytic ('fast twitch') fibers. This phenomenon correlates with the denser network of blood vessels in slow oxidative muscles and more recent investigations have demonstrated that satellite cells are frequently found in the vicinity of blood vessels. There is evidence for crosstalk between satellite cells expressing the receptor Tie2 and neighboring capillary associated cells (for example, pericytes) producing Angiopoietin1, which contributes to the maintenance of quiescence. The Notch pathway has also now been implicated in the maintenance of quiescence. If Notch signaling is disrupted, satellite cells spontaneously activate and differentiate in the absence of injury. Surprisingly, this takes place without proliferation, leading to depletion of satellite cells, so that regeneration is impaired [54, 55]. Satellite cells express the Notch receptor, but the source of the ligand required to activate the pathway is not yet clear. However, the muscle fiber is probably the best candidate, since it is in direct contact with the satellite cell and Notch ligands are transmembrane proteins. Furthermore, there is experimental evidence for production of the Notch ligand Delta by the fiber .
Building one's own nest - what the olfactory epithelium suggests about neuronal stem cell niches
Anne L Calof
Since the central nervous system (CNS) does not regenerate to any significant extent, at least in mammals, it was long assumed that the CNS lacks stem cells (rendering any questions about neuronal stem cell niches moot). In the 1960s, however, investigators such as Joseph Altman and colleagues, using the new technique of injecting 3H-thymidine to label cells in S phase, obtained evidence that some CNS glial cells - and a few cells that were apparently neurons (generally defined as being post-mitotic, terminally differentiated cells) - were the progeny of progenitor cells still functioning (dividing) in postnatal rodents [59–61]. These progenitor cells were found in the regions near the lateral ventricles of the forebrain (the subventricular zone, or SVZ) and a part of the dentate gyrus of the hippocampus now often referred to, by analogy, as the subgranular zone (SGZ).
Now, five decades later, hundreds of articles have been devoted to the study of neuronal stem cells in these two regions (the SVZ and the SGZ), which still appear to be the only consistent sites of sustained neurogenesis and neuronal regeneration in the mammalian CNS. As a result, a lot is being learned about the nature of the 'niches' that support proliferation, self-renewal, and differentiation of stem cells into neurons and glia in these regions of the brain [62–64]. As one might expect, most signaling molecule families that are important in neural development (EGFs, TGF-βs, FGFs, Notch, Shh, and others) are also important in the maintenance of stem cells in the adult brain, and can be found in or around these niches [65–67]. It is not surprising, and certainly significant, that regions of the brain that retain characteristics of the embryonic environment in which the brain was generated are crucial for the maintenance of stem cells that retain the capacity for generating neurons. Another very interesting aspect of these CNS niches is that they are invariably juxtaposed to supporting cell tissues: they are found near blood vessels, the ventricles that line the brain (and hence near both ependymal cells and the cerebrospinal fluid these cells produce), or both .
Such juxtapostion of neuronal stem cells with non-neural supporting cell tissue is characteristic of a part of the peripheral nervous system that is famous for its ability to maintain lifelong neurogenesis: the olfactory epithelium (OE). The OE generates - and regenerates - olfactory receptor neurons (ORNs) throughout life from stem cells that lie in the basal compartment of the epithelium; and it does so robustly in response to injury (for example,  and references therein). Importantly, the OE maintains throughout life striking structural similarities to the neuroepithelial primordia that generate the rest of the nervous system, including its epithelial structure and its dependence on a subjacent stroma derived from mesenchyme and neural crest [70, 71]. This stroma is required for the maintenance of stem cell activity, since survival of isolated OE neural stem cells at low density is only possible when they are cultured on stromal feeder cells .
It appears, then, that OE neural stem cells, together with their neighbors, assemble their own niche. The question for the future is whether the same is true for those areas of the CNS that have the capacity to regenerate. Thus, it should be fruitful to take a closer look at SVZ and SGZ development, focusing in particular on how development initially constructs the cellular neighborhood in which the stem cells of these mature structures come to reside.
Hematopoietic stem cell-niche units in the bone marrow
Hematopoietic stem cell (HSC) niches in the bone marrow are defined as the cellular and molecular microenvironment that regulates HSC function . This includes control of the balance between dormancy and active self-renewal division as well as progenitor output and early lineage decisions. Niche-derived signals regulate HSC function in conjunction with cell autonomous mechanisms by forming HSC-niche units in which HSCs and niche cells exchange signals to generate a stable, but dynamic and flexible, entity . Most importantly, niches are not only essential for control of HSC function during homeostasis, but niche-derived signals are also critical for the engagement of specific programs in response to stress. Bone marrow stress can be induced by bleeding or by cell loss induced by toxic substances, including chemotherapeutic agents. In addition, bacterial or viral infections and the associated inflammatory responses have a significant effect on HSCs and thus likely also on their niches . However, these issues have only started to be addressed experimentally. The goal of these repair processes in the bone is to rapidly restore homeostasis and have the highly precious HSCs return to a protected dormant state.
It is evident that a prerequisite for studying stem cell niches is detailed knowledge about the identity and precise localization of stem cells themselves. HSCs, which mostly reside in the marrow of the long bones, hips and spine, can be identified and isolated prospectively by multi-parameter flow cytometry (FACS) and show a LinnegSca1hic-Kit+CD34-CD48-CD150hi phenotype. At the clonal level, they can reconstitute the entire hematopoietic system of lethally irradiated mice and are serially transplantable [80, 81]. The population of HSCs as defined above contains at least two subsets. First, active HSCs, which ensure the continuous production of new blood cells during steady-state homeostasis, and second, a numerically smaller HSC population harboring superior self-renewal capacity. During homeostasis this smaller HSC population is retained in a state of dormancy (dormant HSCs). In response to stress, niche signals activate them so that they can be involved in the repair process after injury [81–84]. Both dormant and active HSCs are preferentially found as single stem cells enriched in the trabecular regions of long bones. However, there is significant debate about the more detailed location of HSCs within the marrow, which contains both the endosteal region close to the bone lining osteoblasts (OBs; endosteal niche) and a vascular niche located around small sinusoidal blood vessels associated with various stromal and neuronal elements. While FACS allows us to combine at least eight parameters to identify HSCs ex vivo, advanced fluorescence microscope technology used to image HSC-niche units on bone sections is much more limited, making the localization of endogenous HSCs and their niche cells in tissue sections highly challenging [78, 85, 86].
Finally, expression of SCF, which stimulates the Kit receptor on HSCs, and which is long known to activate a signaling pathway absolutely required for HSC development, maturation and function, has also been studied by knock-in reporter mice . This study suggests that SCF is moderately expressed by endothelial cells of the marrow sinusoids and at higher levels by associated leptin receptor-expressing perivascular stromal (LEPS) cells. Genetic elimination of SCF from both cell types leads to loss of most HSCs, indicating the relevance of these cells for HSC function . Since LEPS cells do not express nestin, they are distinct from MSCs and Schwann cells, but one cannot exclude the possibility that they overlap with CAR cells .
In summary, several cell types cooperate to produce secreted and membrane-bound signaling molecules controlling HSC maintenance, fate and function, thus contributing to the formation of the complex HSC-niche unit. These signal/receptor pairs include: SCF/KIT; CXCL12/CXCR4, TGF-β/TGFβ RII, Ang-1/Tie2 and thrombopoietin/MPL and several others with more fine tuning effects on HSCs [77, 89–93]. The last three have been suggested to promote dormancy or hibernation, a typical feature of the most potent HSCs during homeostasis [81, 94]. Future research will need to decipher the three-dimensional network of the HSC-niche unit, and to dissect the various extracellular signals and how these are translated into HSC fate and function. In addition, it will be important to unravel the architectural, cellular and molecular changes within the HSC-niche units in response to various stress situations, including bacterial and viral infections as well as chemotherapy-induced toxicity. Not only will a better understanding of these processes in mice and humans allow us to understand more clearly the many different facets of HSC biology during homeostasis and stress, but it may also provide direct clinical applications for many disease areas as well as for regenerative medicine.
Cancer stem cells and metastatic niches
During the progression of cancer and formation of metastasis, tumor cells enter the circulation and are seeded to distant organs where they have to resist and overcome a non-permissive environment to survive. These events can occur early and may already have taken place long before diagnosis of the primary tumor . Increasing evidence suggests that, like normal stem cells, tumor-initiating cells, termed cancer stem cells, do not depend solely on cell-intrinsic events but instead rely heavily on the right microenvironment - or niche - to maintain activity and fitness . However, unlike normal stem cell niches, which have evolved for millions of years, resulting in a fine-tuned crosstalk between stem cells and their environment, the cancer - or metastatic - niche evolves in a remarkably short time, resulting in more disordered interactions. The location of metastatic niches is also more loosely defined and can change as the disease progresses. Hypoxic regions, invasive fronts, perivascular sides and normal stem cell niches are all possible locations where metastatic niches can form. Normal stem cell niches are influenced by the stem cells themselves, but the metastatic niche takes this to new heights. Recruitment of inflammatory cells, endothelial cells and myofibroblasts to the metastatic niche leads to a tremendously complex milieu of growth factors, chemokines, hormones, enzymes and ECM that can promote stem/progenitor cell traits [97, 98]. The niche that these components form may provide cancer stem cells with the necessary support to survive and grow into overt metastasis.
The qualities of metastatic niches are beginning to be resolved. Despite the somewhat chaotic nature of these niches, interesting parallels can be drawn between them and normal stem cell niches. Certain qualities and molecular interactions within the cancer niche are indeed directly adopted from normal niches. Many of these components are inducers and regulators of stem/progenitor pathways like the Wnt, Notch, Hedgehog, phosphoinositide 3-kinase (PI3K) and JAK-STAT pathways [99, 100]. Moreover, evidence is accumulating on the importance of stem cell features in cancer progression and these properties are associated with poor clinical outcome . Intriguingly, evidence supports not only a passive role of the niche maintaining already established stem/progenitor cell traits, but also that niche components can induce the cancer stem cell phenotype in already differentiated cancer cells. In colon carcinoma, myofibroblasts express hepatocyte growth factor (HGF), a ligand of c-Met receptor tyrosine kinase, leading to co-stimulation and enhancement of Wnt signaling in differentiated cancer cells and promoting their stem/progenitor properties . This underscores the importance of the niche and may be a key feature of the cancer niche since the cancer stem cell phenotype may be a rather unstable and context-dependent trait [102–104].
Important components of the metastatic niche can be expressed by the cancer cells themselves, thereby making cancer cells self-sufficient in this regard since they bring their own niche material to the distant site. The cancer cells that can produce components of a supportive niche on their own will gain a significant advantage upon their arrival in a non-permissive environment. These components can be various growth factors, chemokines or secreted enzymes. Moreover, the ECM can play a significant role in these events. It is increasingly appreciated that the ECM provides more than a structural scaffold for cancer cells and is actively involved in modulating cellular signaling . Indeed, the ECM protein tenascin C (TNC) expressed in normal stem cell niches [117, 118] was recently demonstrated to play an important role in metastatic breast cancer. Modulation of stem/progenitor signaling pathways as a result of TNC expression by the cancer cells was shown to be essential to 'jump-start' the growth of lung metastasis in breast cancer (Figure 8c) . The expression of TNC is frequently found in circulating cancer cells isolated from the pleural effusion of patients with systemic breast cancer, suggesting that cancer cell autonomy in TNC production may have a role in the broad and efficient spread of the disease . Moreover, upon activation of the microenvironment, TNC is produced by myofibroblasts and contributes further to metastatic progression [119, 120]. In addition to TNC, myofibroblasts produce periostin (POSTN), another ECM protein recently identified as a component of the metastatic niche (Figure 8d) . Interestingly, the role of POSTN in formation of lung metastasis shows a striking similarity to the role of TNC, tempting us to hypothesize that these molecules could be inter-connected or collaborative components of the same supportive system . TNC and POSTN were demonstrated to regulate key signaling pathways involved in the maintenance of cancer stem cell features and activity of Wnt and Notch pathways [119, 121]. Disseminated cancer stem cells engage these pathways to resist the inhospitable environment at distant sites.
Today, metastasis is essentially an incurable disease and there is a desperate need for new measures to target metastatic progression. The microenvironment that metastatic cells engage and take advantage of to form a niche is a significant contributor to metastatic outgrowth. Moreover, the niche may possibly also contribute to cancer stem cell resistance to therapeutic intervention. Future studies may lead to identification of niche components that could provide new targets against metastatic progression. Targeting the niche and disrupting the nurturing effect it provides could present us with new means to prevent or even treat metastatic disease.
Arthur D Lander
ADL was supported by NIH grant GM076516.
I thank Sarah Crittenden for comments on the manuscript. Work in the Kimble lab is supported by NIH RO1 GM069454. JK is an investigator in the Howard Hughes Medical Institute.
EF is an Investigator of the Howard Hughes Medical Institute and receives funding for this work from the National Institutes of Health and the New York State Stem Cell Granting Agency.
Didier Montarras and Margaret Buckingham
The authors thank Didier Rocancourt for drawing the figure.
The laboratory of MB and DM is supported by the Institut Pasteur and the CNRS, with grants from the AFM and the European Union programmes OPTISTEM (grant number 223098); EuroSyStem (grant number 200720).
Anne L Calof
Work from the Calof lab was supported by NIH grants DC03583 and GM076516.
This work was supported by the BioRN Spitzencluster 'Molecular and Cell based Medicine' supported by the German Bundesministerium für Bildung und Forschung (BMBF), the EU-FP7 Program 'EuroSyStem', the SFB 873 funded by the Deutsche Forschungsgemeinschaft (DFG) and the Dietmar Hopp Foundation.
I thank S Acharyya for reading this manuscript and useful comments. This work was supported by the Dietmar Hopp Foundation.
- Schofield R: The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978, 4: 7-25.PubMedGoogle Scholar
- Kimble JE, White JG: On the control of germ cell development in Caenorhabditis elegans. Dev Biol. 1981, 81: 208-219. 10.1016/0012-1606(81)90284-0.PubMedGoogle Scholar
- Crittenden SL, Leonhard KA, Byrd DT, Kimble J: Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line. Mol Biol Cell. 2006, 17: 3051-3061. 10.1091/mbc.E06-03-0170.PubMedPubMed CentralGoogle Scholar
- Morgan DE, Crittenden SL, Kimble J: The C. elegans adult male germline: Stem cells and sexual dimorphism. Dev Biol. 2010, 346: 204-214. 10.1016/j.ydbio.2010.07.022.PubMedPubMed CentralGoogle Scholar
- Cinquin O, Crittenden SL, Morgan DE, Kimble J: Progression from a stem cell-like state to early differentiation in the C. elegans germ line. Proc Natl Acad Sci USA. 2010, 107: 2048-2053. 10.1073/pnas.0912704107.PubMedPubMed CentralGoogle Scholar
- Angelo G, Van Gilst M: Starvation protects germline stem cells and extends reproductive longevity in C. elegans. Science. 2009, 326: 954-958. 10.1126/science.1178343.PubMedGoogle Scholar
- Seidel HS, Kimble J: The oogenic germline starvation response in C. elegans. PLoS ONE. 2011, 6: e28074-10.1371/journal.pone.0028074.PubMedPubMed CentralGoogle Scholar
- Byrd DT, Kimble J: Scratching the niche that controls Caenorhabditis elegans germline stem cells. Semin Cell Dev Biol. 2009, 20: 1107-1113. 10.1016/j.semcdb.2009.09.005.PubMedPubMed CentralGoogle Scholar
- Jeong J, Verheyden JM, Kimble J: Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet. 2011, 7: e1001348-10.1371/journal.pgen.1001348.PubMedPubMed CentralGoogle Scholar
- Kimble J, Crittenden SL: Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans. Annu Rev Cell Dev Biol. 2007, 23: 405-433. 10.1146/annurev.cellbio.23.090506.123326.PubMedGoogle Scholar
- Kershner AM, Kimble J: Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator. Proc Natl Acad Sci USA. 2010, 107: 3936-3941. 10.1073/pnas.1000495107.PubMedPubMed CentralGoogle Scholar
- Merritt C, Seydoux G: The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. Development. 2010, 137: 1787-1798. 10.1242/dev.050799.PubMedPubMed CentralGoogle Scholar
- Austin J, Kimble J: glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell. 1987, 51: 589-599. 10.1016/0092-8674(87)90128-0.PubMedGoogle Scholar
- Nadarajan S, Govindan JA, McGovern M, Hubbard EJA, Greenstein D: MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans. Development. 2009, 136: 2223-2234. 10.1242/dev.034603.PubMedPubMed CentralGoogle Scholar
- Kimble J, Hirsh D: The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol. 1979, 70: 396-417. 10.1016/0012-1606(79)90035-6.PubMedGoogle Scholar
- Kidd AR, Miskowski JA, Siegfried KR, Sawa H, Kimble J: A β-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling. Cell. 2005, 121: 761-772. 10.1016/j.cell.2005.03.029.PubMedGoogle Scholar
- Lam N, Chesney MA, Kimble J: Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Curr Biol. 2006, 16: 287-295. 10.1016/j.cub.2005.12.015.PubMedPubMed CentralGoogle Scholar
- McGovern M, Voutev R, Maciejowski J, Corsi AK, Hubbard EJ: A 'latent niche' mechanism for tumor initiation. Proc Natl Acad Sci USA. 2009, 106: 11617-11622. 10.1073/pnas.0903768106.PubMedPubMed CentralGoogle Scholar
- Hall DH, Winfrey VP, Blaeuer G, Hoffman LH, Furuta T, Rose KL, Hobert O, Greenstein D: Ultrastructural features of the adult hermaphrodite gonad of Caenorhabditis elegans: Relations between the germ line and soma. Dev Biol. 1999, 212: 101-123. 10.1006/dbio.1999.9356.PubMedGoogle Scholar
- Morrison SJ, Spradling AC: Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell. 2008, 132: 598-611. 10.1016/j.cell.2008.01.038.PubMedPubMed CentralGoogle Scholar
- Marshman E, Booth C, Potten CS: The intestinal epithelial stem cell. Bioessays. 2002, 24: 91-98. 10.1002/bies.10028.PubMedGoogle Scholar
- van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H: Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 2009, 136: 903-912. 10.1016/j.cell.2009.01.031.PubMedGoogle Scholar
- Cheng H, Leblond CP: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am J Anat. 1974, 141: 461-479. 10.1002/aja.1001410403.PubMedGoogle Scholar
- Cheng H, Leblond CP: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat. 1974, 141: 537-561. 10.1002/aja.1001410407.PubMedGoogle Scholar
- Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H: Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007, 449: 1003-1007. 10.1038/nature06196.PubMedGoogle Scholar
- Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ: Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009, 457: 603-607. 10.1038/nature07589.PubMedPubMed CentralGoogle Scholar
- Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009, 459: 262-265. 10.1038/nature07935.PubMedGoogle Scholar
- Bjerknes M, Cheng H: The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am J Anat. 1981, 160: 51-63. 10.1002/aja.1001600105.PubMedGoogle Scholar
- Schofield R: The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978, 4: 7-25.PubMedGoogle Scholar
- Fuchs E: The Tortoise and the Hair: slow-cycling cells in the stem cell race. Cell. 2009, 137: 811-819. 10.1016/j.cell.2009.05.002.PubMedPubMed CentralGoogle Scholar
- Cotsarelis G, Sun TT, Lavker RM: Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell. 1990, 61: 1329-1337. 10.1016/0092-8674(90)90696-C.PubMedGoogle Scholar
- Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y: Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell. 2001, 104: 233-245. 10.1016/S0092-8674(01)00208-2.PubMedGoogle Scholar
- Nishimura EK, Jordan SA, Oshima H, Yoshida H, Osawa M, Moriyama M, Jackson IJ, Barrandon Y, Miyachi Y, Nishikawa S: Dominant role of the niche in melanocyte stem-cell fate determination. Nature. 2002, 416: 854-860. 10.1038/416854a.PubMedGoogle Scholar
- Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK: Hair follicle stem cells provide a functional niche for melanocyte stem cells. Cell Stem Cell. 2011, 8: 177-187. 10.1016/j.stem.2010.11.029.PubMedGoogle Scholar
- Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM: The basement membrane of hair follicle stem cells Is a muscle cell niche. Cell. 2011, 144: 577-589. 10.1016/j.cell.2011.01.014.PubMedPubMed CentralGoogle Scholar
- Gat U, DasGupta R, Degenstein L, Fuchs E: De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell. 1998, 95: 605-614. 10.1016/S0092-8674(00)81631-1.PubMedGoogle Scholar
- Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER: Transient activation of beta-catenin signaling in cutaneous keratinocytes is to trigger the active growth phase of the hair cycle in mice. Genes Dev. 2003, 17: 1219-1224. 10.1101/gad.1076103.PubMedPubMed CentralGoogle Scholar
- Lo Celso C, Prowse DM, Watt FM: Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development. 2004, 131: 1787-1799. 10.1242/dev.01052.PubMedGoogle Scholar
- Oshimori N, Fuchs E: Paracrine TGF-beta signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell. 2012, 10: 63-75. 10.1016/j.stem.2011.11.005.PubMedPubMed CentralGoogle Scholar
- Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E: Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci USA. 2007, 104: 10063-10068. 10.1073/pnas.0703004104.PubMedPubMed CentralGoogle Scholar
- Andl T, Ahn K, Kairo A, Chu EY, Wine-Lee L, Reddy ST, Croft NJ, Cebra-Thomas JA, Metzger D, Chambon P, Lyons KM, Mishina Y, Seykora JT, Crenshaw EB, Millar SE: Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development. 2004, 131: 2257-2268. 10.1242/dev.01125.PubMedGoogle Scholar
- Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E: A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration. Cell Stem Cell. 2009, 4: 155-169. 10.1016/j.stem.2008.12.009.PubMedPubMed CentralGoogle Scholar
- Rabbani P, Takeo M, Chou W, Myung P, Bosenberg M, Chin L, Taketo MM, Ito M: Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell. 2011, 145: 941-955. 10.1016/j.cell.2011.05.004.PubMedPubMed CentralGoogle Scholar
- Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L: Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells. 2006, 24: 2826-2839. 10.1634/stemcells.2005-0544.PubMedGoogle Scholar
- Zhang YV, Cheong J, Ciapurin N, McDermitt DJ, Tumbar T: Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell. 2009, 5: 267-278. 10.1016/j.stem.2009.06.004.PubMedPubMed CentralGoogle Scholar
- Hsu YC, Pasolli HA, Fuchs E: Dynamics between stem cells, niche, and progeny in the hair follicle. Cell. 2011, 144: 92-105. 10.1016/j.cell.2010.11.049.PubMedPubMed CentralGoogle Scholar
- Plikus MV, Mayer JA, de la Cruz D, Baker RE, Maini PK, Maxson R, Chuong CM: Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008, 451: 340-344. 10.1038/nature06457.PubMedPubMed CentralGoogle Scholar
- Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM: Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science. 2011, 332: 586-589. 10.1126/science.1201647.PubMedPubMed CentralGoogle Scholar
- Festa E, Fretz J, Berry R, Schmidt B, Rodeheffer M, Horowitz M, Horsley V: Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling. Cell. 2011, 146: 761-771. 10.1016/j.cell.2011.07.019.PubMedPubMed CentralGoogle Scholar
- Buckingham M, Montarras D: Skeletal muscle stem cells. Curr Opin Genet Dev. 2008, 4: 330-336.Google Scholar
- Mauro A: Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol. 1961, 9: 493-495. 10.1083/jcb.9.2.493.PubMedPubMed CentralGoogle Scholar
- Wokke JH, Van den Oord CJ, Leppink GJ, Jennekens FG: Perisynaptic satellite cells in human external intercostal muscle: a quantitative and qualitative study. Anat Rec. 1989, 223: 174-180. 10.1002/ar.1092230209.PubMedGoogle Scholar
- Mounier R, Chrétien F, Chazaud B: Blood vessels and the satellite cell niche. Curr Top Dev Biol. 2011, 96: 121-138.PubMedGoogle Scholar
- Bjornson CR, Cheung TH, Liu L, Tripathi PV, Steeper KM, Rando TA: Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells. 2011, 30: 232-242.Google Scholar
- Mourikis P, Sambasivan R, Castel D, Rocheteau P, Bizarro V, Tajbakhsh S: A critical requirement for Notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells. 2011, 30: 243-252.Google Scholar
- Conboy IM, Conboy MJ, Smythe GM, Rando TA: Notch mediated restoration of regenerative potential potential to aged muscle. Science. 2003, 302: 1575-1577. 10.1126/science.1087573.PubMedGoogle Scholar
- Pallafacchina G, François S, Regnault B, Czarny B, Dive V, Cumano A, Montarras D, Buckingham M: An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells. Stem Cell Res. 2010, 4: 77-91. 10.1016/j.scr.2009.10.003.PubMedGoogle Scholar
- Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP, Ai X: Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. Dev Biol. 2007, 311: 464-477. 10.1016/j.ydbio.2007.08.053.PubMedGoogle Scholar
- Altman J: Autoradiographic study of degenerative and regenerative proliferation of neuroglia cells with tritiated thymidine. Exp Neurol. 1962, 5: 302-318. 10.1016/0014-4886(62)90040-7.PubMedGoogle Scholar
- Altman J: Are new neurons formed in the brains of adult mammals?. Science. 1962, 135: 1127-1128. 10.1126/science.135.3509.1127.PubMedGoogle Scholar
- Altman J, Das GD: Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol. 1965, 124: 319-335. 10.1002/cne.901240303.PubMedGoogle Scholar
- Doetsch F: A niche for adult neural stem cells. Curr Opin Genet Dev. 2003, 13: 543-550. 10.1016/j.gde.2003.08.012.PubMedGoogle Scholar
- Alvarez-Buylla A, Lim DA: For the long run: maintaining germinal niches in the adult brain. Neuron. 2004, 41: 683-686. 10.1016/S0896-6273(04)00111-4.PubMedGoogle Scholar
- Moore KA, Lemischka IR: Stem cells and their niches. Science. 2006, 311: 1880-1885. 10.1126/science.1110542.PubMedGoogle Scholar
- Riquelme PA, Drapeau E, Doetsch F: Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos Trans R Soc Lond B Biol Sci. 2008, 363: 123-137. 10.1098/rstb.2006.2016.PubMedPubMed CentralGoogle Scholar
- Ferrón SR, Charalambous M, Radford E, McEwen K, Wildner H, Hind E, Morante-Redolat JM, Laborda J, Guillemot F, Bauer SR, Fariñas I, Ferguson-Smith AC: Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature. 2011, 475: 381-385. 10.1038/nature10229.PubMedPubMed CentralGoogle Scholar
- Gomez-Gaviro MV, Scott CE, Sesay AK, Matheu A, Booth S, Galichet C, Lovell-Badge R: Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis. Proc Natl Acad Sci USA. 2012, 109: 1317-1322. 10.1073/pnas.1016199109.PubMedPubMed CentralGoogle Scholar
- Ihrie RA, Alvarez-Buylla A: Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. Neuron. 2011, 70: 674-686. 10.1016/j.neuron.2011.05.004.PubMedPubMed CentralGoogle Scholar
- Gokoffski KK, Kawauchi S, Wu HH, Santos R, Hollenbeck PLW, Lander AD, Calof AL: Feedback regulation of neurogenesis in the mammalian olfactory epithelium: new insights from genetics and systems biology. The Neurobiology of Olfaction. Edited by: Menini A. 2010, Boca Raton: CRC Press, 241-266.Google Scholar
- Kawauchi S, Beites CL, Crocker CE, Wu HH, Bonnin A, Murray R, Calof AL: Molecular signals regulating proliferation of stem and progenitor cells in mouse olfactory epithelium. Dev Neurosci. 2004, 26: 166-180. 10.1159/000082135.PubMedGoogle Scholar
- Beites CL, Kawauchi S, Crocker CE, Calof AL: Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp Cell Res. 2005, 306: 309-316. 10.1016/j.yexcr.2005.03.027.PubMedGoogle Scholar
- Mumm JS, Shou J, Calof AL: Colony-forming progenitors from mouse olfactory epithelium: evidence for feedback regulation of neuron production. Proc Natl Acad Sci USA. 1996, 93: 11167-11172. 10.1073/pnas.93.20.11167.PubMedPubMed CentralGoogle Scholar
- Wu HH, Ivkovic S, Murray RC, Jaramillo S, Lyons KM, Johnson JE, Calof AL: Autoregulation of neurogenesis by GDF11. Neuron. 2003, 37: 197-207. 10.1016/S0896-6273(02)01172-8.PubMedGoogle Scholar
- Lander AD, Gokoffski KK, Wan FY, Nie Q, Calof AL: Cell lineages and the logic of proliferative control. PLoS Biol. 2009, 7: e15-10.1371/journal.pbio.1000015.PubMedGoogle Scholar
- Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL: Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011, 138: 4131-4142. 10.1242/dev.065870.PubMedPubMed CentralGoogle Scholar
- Lo WC, Chou CS, Gokoffski KK, Wan FY, Lander AD, Calof AL, Nie Q: Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009, 6: 59-82.PubMedPubMed CentralGoogle Scholar
- Wilson A, Trumpp A: Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol. 2006, 6: 93-106. 10.1038/nri1779.PubMedGoogle Scholar
- Ehninger A, Trumpp A: The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J Exp Med. 208: 421-428.Google Scholar
- Trumpp A, Essers M, Wilson A: Awakening dormant haematopoietic stem cells. Nat Rev Immunol. 2010, 10: 201-209. 10.1038/nri2726.PubMedGoogle Scholar
- Purton LE, Scadden DT: Limiting factors in murine hematopoietic stem cell assays. Cell Stem Cell. 2007, 1: 263-270. 10.1016/j.stem.2007.08.016.PubMedGoogle Scholar
- Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A: Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008, 135: 1118-1129. 10.1016/j.cell.2008.10.048.PubMedGoogle Scholar
- Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A: IFNα activates dormant haematopoietic stem cells in vivo. Nature. 2009, 458: 904-908. 10.1038/nature07815.PubMedGoogle Scholar
- Takizawa H, Regoes RR, Boddupalli CS, Bonhoeffer S, Manz MG: Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. J Exp Med. 2011, 208: 273-284. 10.1084/jem.20101643.PubMedPubMed CentralGoogle Scholar
- King KY, Goodell MA: Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 11: 685-692.Google Scholar
- Kiel MJ, Morrison SJ: Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol. 2008, 8: 290-301. 10.1038/nri2279.PubMedGoogle Scholar
- Park D, Sykes DB, Scadden DT: The hematopoietic stem cell niche. Front Biosci. 17: 30-39.Google Scholar
- Omatsu Y, Sugiyama T, Kohara H, Kondoh G, Fujii N, Kohno K, Nagasawa T: The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010, 33: 387-399. 10.1016/j.immuni.2010.08.017.PubMedGoogle Scholar
- Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS: Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010, 466: 829-834. 10.1038/nature09262.PubMedPubMed CentralGoogle Scholar
- Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H: Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell. 147: 1146-1158.Google Scholar
- Ding L, Saunders TL, Enikolopov G, Morrison SJ: Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 481: 457-462.Google Scholar
- Nagasawa T, Omatsu Y, Sugiyama T: Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells. Trends Immunol. 32: 315-320.Google Scholar
- Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T: Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004, 118: 149-161. 10.1016/j.cell.2004.07.004.PubMedGoogle Scholar
- Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, Miyazaki H, Takahashi T, Suda T: Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell. 2007, 1: 685-697. 10.1016/j.stem.2007.10.020.PubMedGoogle Scholar
- Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H: TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood. 2009, 113: 1250-1256. 10.1182/blood-2008-04-146480.PubMedGoogle Scholar
- Pantel K, Alix-Panabieres C, Riethdorf S: Cancer micrometastases. Nat Rev Clin Onc. 2009, 6: 339-351. 10.1038/nrclinonc.2009.44.Google Scholar
- Cabarcas SM, Mathews LA, Farrar WL: The cancer stem cell niche - there goes the neighborhood?. Int J Cancer. 2011, 129: 2315-2327. 10.1002/ijc.26312.PubMedGoogle Scholar
- Joyce JA, Pollard JW: Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009, 9: 239-252. 10.1038/nrc2618.PubMedPubMed CentralGoogle Scholar
- Korkaya H, Liu S, Wicha MS: Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest. 2011, 121: 3804-3809. 10.1172/JCI57099.PubMedPubMed CentralGoogle Scholar
- Takebe N, Harris PJ, Warren RQ, Ivy SP: Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Onc. 2011, 8: 97-106. 10.1038/nrclinonc.2010.196.Google Scholar
- Dreesen O, Brivanlou AH: Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev. 2007, 3: 7-17. 10.1007/s12015-007-0004-8.PubMedGoogle Scholar
- Vermeulen L, Todaro M, de Sousa Mello F, Sprick MR, Kemper K, Perez Alea M, Richel DJ, Stassi G, Medema JP: Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci USA. 2008, 105: 13427-13432. 10.1073/pnas.0805706105.PubMedPubMed CentralGoogle Scholar
- Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA: Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell. 2011, 145: 926-940. 10.1016/j.cell.2011.04.029.PubMedPubMed CentralGoogle Scholar
- Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA: Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci USA. 2011, 108: 7950-7955. 10.1073/pnas.1102454108.PubMedPubMed CentralGoogle Scholar
- Iliopoulos D, Hirsch HA, Wang G, Struhl K: Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA. 2011, 108: 1397-1402. 10.1073/pnas.1018898108.PubMedPubMed CentralGoogle Scholar
- Wong CW, Lee A, Shientag L, Yu J, Dong Y, Kao G, Al-Mehdi AB, Bernhard EJ, Muschel RJ: Apoptosis: an early event in metastatic inefficiency. Cancer Res. 2001, 61: 333-338.PubMedGoogle Scholar
- Cameron MD, Schmidt EE, Kerkvliet N, Nadkarni KV, Morris VL, Groom AC, Chambers AF, MacDonald IC: Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 2000, 60: 2541-2546.PubMedGoogle Scholar
- Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D: VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005, 438: 820-827. 10.1038/nature04186.PubMedPubMed CentralGoogle Scholar
- Psaila B, Lyden D: The metastatic niche: adapting the foreign soil. Nat Rev Cancer. 2009, 9: 285-293. 10.1038/nrc2621.PubMedPubMed CentralGoogle Scholar
- Shiozawa Y, Pedersen EA, Havens AM, Jung Y, Mishra A, Joseph J, Kim JK, Patel LR, Ying C, Ziegler AM, Pienta MJ, Song J, Wang J, Loberg RD, Krebsbach PH, Pienta KJ, Taichman RS: Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest. 2011, 121: 1298-1312. 10.1172/JCI43414.PubMedPubMed CentralGoogle Scholar
- Ara T, Tokoyoda K, Sugiyama T, Egawa T, Kawabata K, Nagasawa T: Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity. 2003, 19: 257-267. 10.1016/S1074-7613(03)00201-2.PubMedGoogle Scholar
- Sun YX, Schneider A, Jung Y, Wang J, Dai J, Wang J, Cook K, Osman NI, Koh-Paige AJ, Shim H, Pienta KJ, Keller ET, McCauley LK, Taichman RS: Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. J Bone Miner Res. 2005, 20: 318-329.PubMedGoogle Scholar
- Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massague J: Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer cell. 2009, 16: 67-78. 10.1016/j.ccr.2009.05.017.PubMedPubMed CentralGoogle Scholar
- Zlotnik A, Burkhardt AM, Homey B: Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol. 2011, 11: 597-606. 10.1038/nri3049.PubMedGoogle Scholar
- Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005, 121: 335-348. 10.1016/j.cell.2005.02.034.PubMedGoogle Scholar
- Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC: Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med. 2004, 10: 858-864. 10.1038/nm1075.PubMedGoogle Scholar
- Hynes RO: The extracellular matrix: not just pretty fibrils. Science. 2009, 326: 1216-1219. 10.1126/science.1176009.PubMedPubMed CentralGoogle Scholar
- Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E: Defining the epithelial stem cell niche in skin. Science. 2004, 303: 359-363. 10.1126/science.1092436.PubMedPubMed CentralGoogle Scholar
- Garcion E, Halilagic A, Faissner A, ffrench-Constant C: Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development. 2004, 131: 3423-3432. 10.1242/dev.01202.PubMedGoogle Scholar
- Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massague J: Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med. 2011, 17: 867-874. 10.1038/nm.2379.PubMedPubMed CentralGoogle Scholar
- O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R: VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci USA. 2011, 108: 16002-16007. 10.1073/pnas.1109493108.PubMedPubMed CentralGoogle Scholar
- Malanchi I, Santamaria-Martinez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J: Interactions between cancer stem cells and their niche govern metastatic colonization. Nature. 2012, 481: 85-89.Google Scholar
- Oskarsson T, Massague J: Extracellular matrix players in metastatic niches. EMBO J. 2011, 31: 254-256. 10.1038/emboj.2011.469.PubMedPubMed CentralGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.