- Open Access
HIV takes double hit before entry
© Sanders; licensee BioMed Central Ltd. 2012
- Received: 29 November 2012
- Accepted: 5 December 2012
- Published: 7 December 2012
In the absence of a vaccine or a cure, identification of novel HIV-1 inhibitors remains important. A paper in Retrovirology describes a rationally designed bi-specific protein that irreversibly damages the viral envelope glycoprotein complex via a two-punch mechanism. In contrast to traditional drugs that inhibit essential steps in the viral life cycle at the cell surface or in the infected cells, this inhibitor cripples free virus in the absence of cells.
See research article: http://www.retrovirology.com/content/9/1/104
- Fusion Peptide
- Viral Life Cycle
- Free Virus
The author is a recipient of a Vidi fellowship from the Netherlands Organization for Scientific Research (NWO), and a Starting Investigator grant from the European Research Council (ERC-StG-2011-280829-SHEV).
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