BUB2
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-
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-
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Mitotic exit network regulator; blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
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CCR4
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CNOT6
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CCR4-NOT transcription complex, subunit 6
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Component of the CCR4-NOT transcriptional complex
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CDC34
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UBE2R2
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Ubiquitin-conjugating enzyme E2R 2
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Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex that regulates cell cycle progression by targeting key substrates for degradation
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CHK1
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CHEK1
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Serine/threonine kinase and DNA damage checkpoint effector
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Serine/threonine kinase and DNA damage checkpoint effector
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CLB1
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CCNB1
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Cyclin B1
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B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase
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CTF8
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CHTF8
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Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
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Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
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DBF2
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-
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-
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Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis.
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DNL4
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LIG4
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DNA ligase required for non-homologous end-joining; OMIM: Lig4 syndrome
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DNA ligase required for nonhomologous end-joining (NHEJ)
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IDP1
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IDH1
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Isocitrate dehydrogenase 1 (NADP+); OMIM: Oligodendroglioma; piloytic astrocytoma
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Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate
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IRR1
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STAG1
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Stromal antigen 1
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Subunit of the cohesin complex, required for sister chromatid cohesion during mitosis and meiosis
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MAD1
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MAD1L1
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Component of the spindle-assembly checkpoint
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Coiled-coil protein involved in the spindle-assembly checkpoint; forms a complex with Mad2p
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MEU1
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MTAP
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Methylthioadenosine phosphorylase; OMIM: Glioma
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Methylthioadenosine phosphorylase
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MLH1
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MLH1
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mutL homolog 1, colon cancer, nonpolyposis type 2
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Protein required for mismatch repair in mitosis
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MSH2
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MSH2
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mutS homolog 2, colon cancer, nonpolyposis type 1; OMIM: colorectal cancer
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Protein required for mismatch repair in mitosis
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MUS81
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MUS81
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MUS81 endonuclease homolog; OMIM: Bloom syndrome (predisposition to leukemias, lymphomas & carcinomas)
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Subunit of the Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability
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RAD1
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ERCC4
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Excision repair cross-complementing rodent repair deficiency, complementation group 4; OMIM: Xeroderma pigmentosum (predisposition to basal cell carcinoma & melanoma)
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Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair
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RAD54
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RAD54L
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RAD54-like; OMIM: Lymphoma, non-Hodgkin
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DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; recombinational repair of double-strand breaks in DNA
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RAD61
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-
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-
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Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion
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RAD9
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RAD9
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-
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DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p
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SMC2
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SMC2
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Structural maintenance of chromosomes 2
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Subunit of the condensin complex
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STP22
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TSG101
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Tumor susceptibility gene 101; OMIM: Breast cancer
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Component of the ESCRT-I complex
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TOP1
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TOP1
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Topoisomerase (DNA) I
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Topoisomerase I
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TOP2
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TOP2B
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Topoisomerase (DNA) II beta 180kDa
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Topoisomerase II
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TPD3
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PPP2R1B
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Protein phosphatase 2, regulatory subunit A, beta; OMIM: Lung cancer
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Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A)
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TUM1
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TST
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Thiosulfate sulfurtransferase (rhodanese); OMIM: Tumours
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Rhodanese domain sulfur transferase
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UBX4
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ASPSCR1
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Alveolar soft part sarcoma chromosome region, candidate 1; OMIM: Alveolar soft-part sarcoma
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UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
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YCG1
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NCAPG
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non-SMC condensin I complex, subunit G
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Subunit of the condensin complex
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RIM11
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GSK3A
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Glycogen synthase kinase 3 alpha
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Protein kinase required for signal transduction during entry into meiosis
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NBP2
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SH3GL1
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SH3-domain GRB2-like 1; OMIM: Acute myeloid leukemia
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Protein involved in the HOG (high osmolarity glycerol) pathway, contains an SH3 domain that binds Pbs2p
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PBS2
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MAP2K1
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MAP kinase kinase
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MAP kinase kinase of the HOG signaling pathway; mediates cell cycle arrest
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