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BUB2
|
-
|
-
|
Mitotic exit network regulator; blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
|
|
CCR4
|
CNOT6
|
CCR4-NOT transcription complex, subunit 6
|
Component of the CCR4-NOT transcriptional complex
|
|
CDC34
|
UBE2R2
|
Ubiquitin-conjugating enzyme E2R 2
|
Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex that regulates cell cycle progression by targeting key substrates for degradation
|
|
CHK1
|
CHEK1
|
Serine/threonine kinase and DNA damage checkpoint effector
|
Serine/threonine kinase and DNA damage checkpoint effector
|
|
CLB1
|
CCNB1
|
Cyclin B1
|
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase
|
|
CTF8
|
CHTF8
|
Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
|
Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
|
|
DBF2
|
-
|
-
|
Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis.
|
|
DNL4
|
LIG4
|
DNA ligase required for non-homologous end-joining; OMIM: Lig4 syndrome
|
DNA ligase required for nonhomologous end-joining (NHEJ)
|
|
IDP1
|
IDH1
|
Isocitrate dehydrogenase 1 (NADP+); OMIM: Oligodendroglioma; piloytic astrocytoma
|
Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate
|
|
IRR1
|
STAG1
|
Stromal antigen 1
|
Subunit of the cohesin complex, required for sister chromatid cohesion during mitosis and meiosis
|
|
MAD1
|
MAD1L1
|
Component of the spindle-assembly checkpoint
|
Coiled-coil protein involved in the spindle-assembly checkpoint; forms a complex with Mad2p
|
|
MEU1
|
MTAP
|
Methylthioadenosine phosphorylase; OMIM: Glioma
|
Methylthioadenosine phosphorylase
|
|
MLH1
|
MLH1
|
mutL homolog 1, colon cancer, nonpolyposis type 2
|
Protein required for mismatch repair in mitosis
|
|
MSH2
|
MSH2
|
mutS homolog 2, colon cancer, nonpolyposis type 1; OMIM: colorectal cancer
|
Protein required for mismatch repair in mitosis
|
|
MUS81
|
MUS81
|
MUS81 endonuclease homolog; OMIM: Bloom syndrome (predisposition to leukemias, lymphomas & carcinomas)
|
Subunit of the Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability
|
|
RAD1
|
ERCC4
|
Excision repair cross-complementing rodent repair deficiency, complementation group 4; OMIM: Xeroderma pigmentosum (predisposition to basal cell carcinoma & melanoma)
|
Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair
|
|
RAD54
|
RAD54L
|
RAD54-like; OMIM: Lymphoma, non-Hodgkin
|
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; recombinational repair of double-strand breaks in DNA
|
|
RAD61
|
-
|
-
|
Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion
|
|
RAD9
|
RAD9
|
-
|
DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p
|
|
SMC2
|
SMC2
|
Structural maintenance of chromosomes 2
|
Subunit of the condensin complex
|
|
STP22
|
TSG101
|
Tumor susceptibility gene 101; OMIM: Breast cancer
|
Component of the ESCRT-I complex
|
|
TOP1
|
TOP1
|
Topoisomerase (DNA) I
|
Topoisomerase I
|
|
TOP2
|
TOP2B
|
Topoisomerase (DNA) II beta 180kDa
|
Topoisomerase II
|
|
TPD3
|
PPP2R1B
|
Protein phosphatase 2, regulatory subunit A, beta; OMIM: Lung cancer
|
Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A)
|
|
TUM1
|
TST
|
Thiosulfate sulfurtransferase (rhodanese); OMIM: Tumours
|
Rhodanese domain sulfur transferase
|
|
UBX4
|
ASPSCR1
|
Alveolar soft part sarcoma chromosome region, candidate 1; OMIM: Alveolar soft-part sarcoma
|
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
|
|
YCG1
|
NCAPG
|
non-SMC condensin I complex, subunit G
|
Subunit of the condensin complex
|
|
RIM11
|
GSK3A
|
Glycogen synthase kinase 3 alpha
|
Protein kinase required for signal transduction during entry into meiosis
|
|
NBP2
|
SH3GL1
|
SH3-domain GRB2-like 1; OMIM: Acute myeloid leukemia
|
Protein involved in the HOG (high osmolarity glycerol) pathway, contains an SH3 domain that binds Pbs2p
|
|
PBS2
|
MAP2K1
|
MAP kinase kinase
|
MAP kinase kinase of the HOG signaling pathway; mediates cell cycle arrest
|
