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Table 4 Observed apoptotsis-related phenotypes of our HP yeast genes compared with those of their human orthologs

From: Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae

HP yeast gene Human ortholog Apoptotic phenotype (% dead cells) of yeast heterozygous deletion mutants treated with MMS. (Change in rate of apoptosis, relative to WT, is significant at p < 0.05 for all yeast heterozygotes.) Mammalian apoptosis-related phenotype from literature
   0.01% MMS 0.001% MMS  
WT - 79% 68%  
CTF8 CHTF8 49% - -
MSH2 MSH2 56% - RNAi-mediated knockdown decreases apoptosis [25]
MUS81 MUS81 56% - -
TPD3 PPP2R1B 60% - RNAi-mediated knockdown decreases apoptosis [26]
TOP1 TOP1 55% - RNAi-mediated knockdown reduces nuclear apoptosis [27]
RAD54 RAD54L 44%   -
SMC3 SMC3 - 30% RNAi-mediated knockdown increases apoptosis [28]
RAD1 ERCC4 - 22% -
DNL4 LIG4 - 46% Extensive apoptosis in mouse deletion homozygotes [29]
MAD1 MAD1L1 - 20% -
MEU1 MTAP - 94% Pharmacological targeting of MTAP promotes apoptosis [30]
MLH1 MLH1 - 93% Abnormal apoptosis (OMIM)
CHK1 CHEK1 - 82% Blocking CHK1 induces apoptosis [31]
UBX4 ASPSCR1 - 80% Regulator of apoptosis (OMIM)