Miller LH, Ackerman HC, Su X-Z, Wellems TE: Malaria biology and disease pathogenesis: insights for new treatments. Nat Med. 2013, 19: 156-167. 10.1038/nm.3073.
Article
CAS
PubMed
Google Scholar
Dixon MWA, Thompson J, Gardiner DL, Trenholme KR: Sex in Plasmodium: a sign of commitment. Trends Parasitol. 2008, 24: 168-175. 10.1016/j.pt.2008.01.004.
Article
PubMed
Google Scholar
Alano P: Plasmodium falciparum gametocytes: still many secrets of a hidden life. Mol Microbiol. 2007, 66: 291-302. 10.1111/j.1365-2958.2007.05904.x.
Article
CAS
PubMed
Google Scholar
Sherman IW: Biochemistry of Plasmodium (malarial parasites). Microbiol Rev. 1979, 43: 453-495.
PubMed Central
CAS
PubMed
Google Scholar
Planche T, Krishna S: Severe malaria: metabolic complications. Curr Mol Med. 2006, 6: 141-153. 10.2174/156652406776055177.
Article
CAS
PubMed
Google Scholar
Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB: Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function. Eukaryot Cell. 2011, 10: 1053-1061. 10.1128/EC.05049-11.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fleck SL, Pudney M, Sinden RE: The effect of atovaquone (566C80) on the maturation and viability of Plasmodium falciparum gametocytes in vitro. Trans R Soc Trop Med Hyg. 1996, 90: 309-312. 10.1016/S0035-9203(96)90266-7.
Article
CAS
PubMed
Google Scholar
Painter HJ, Morrisey JM, Mather MW, Vaidya AB: Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature. 2007, 446: 88-91. 10.1038/nature05572.
Article
CAS
PubMed
Google Scholar
Vaidya AB, Painter HJ, Morrisey JM, Mather MW: The validity of mitochondrial dehydrogenases as antimalarial drug targets. Trends Parasitol. 2008, 24: 8-9. 10.1016/j.pt.2007.10.005.
Article
CAS
PubMed
Google Scholar
Foth BJ, Stimmler LM, Handman E, Crabb BS, Hodder AN, McFadden GI: The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol. 2005, 55: 39-53.
Article
CAS
PubMed
Google Scholar
Bryant C, Voller A, Smith MJ: The incorporation of radioactivity from (14c)glucose into the soluble metabolic intermediates of malaria parasites. Am J Trop Med Hyg. 1964, 13: 515-519.
CAS
PubMed
Google Scholar
Mogi T, Kita K: Diversity in mitochondrial metabolic pathways in parasitic protists Plasmodium and Cryptosporidium. Parasitol Int. 2010, 59: 305-312. 10.1016/j.parint.2010.04.005.
Article
CAS
PubMed
Google Scholar
Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M: Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 2010, 466: 774-778. 10.1038/nature09301.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sana TR, Gordon DB, Fischer SM, Tichy SE, Kitagawa N, Lai C, Gosnell WL, Chang SP: Global mass spectrometry based metabolomics profiling of erythrocyte infected. PLoS One. 2013, 8: e60840-10.1371/journal.pone.0060840.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bulusu V, Jayaraman V, Balaram H: Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum. J Biol Chem. 2011, 286: 9236-9245. 10.1074/jbc.M110.173328.
Article
PubMed Central
CAS
PubMed
Google Scholar
Storm J, Müller S: The phenotype of a Plasmodium falciparum phosphoeno/pyruvate carboxylase null mutant. Malar J. 2010, 9: P49-10.1186/1475-2875-9-S2-P49.
Article
PubMed Central
Google Scholar
Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M: Retraction: branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 2013, 497: 652-
Article
PubMed Central
CAS
PubMed
Google Scholar
Hino A, Hirai M, Tanaka TQ, Watanabe Y-I, Matsuoka H, Kita K: Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei. J Biochem. 2012, 152: 259-268. 10.1093/jb/mvs058.
Article
CAS
PubMed
Google Scholar
Tanaka TQ, Hirai M, Watanabe Y-I, Kita K: Toward understanding the role of mitochondrial complex II in the intraerythrocytic stages of Plasmodium falciparum: gene targeting of the Fp subunit. Parasitol Int. 2012, 61: 726-728. 10.1016/j.parint.2012.06.002.
Article
CAS
PubMed
Google Scholar
Boysen KE, Matuschewski K: Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase. J Biol Chem. 2011, 286: 32661-32671. 10.1074/jbc.M111.269399.
Article
PubMed Central
CAS
PubMed
Google Scholar
Macrae JI, Sheiner L, Nahid A, Tonkin C, Striepen B, McConville MJ: Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe. 2012, 12: 682-692. 10.1016/j.chom.2012.09.013.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dixon MWA, Dearnley MK, Hanssen E, Gilberger T, Tilley L: Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?. Trends Parasitol. 2012, 28: 471-478. 10.1016/j.pt.2012.07.007.
Article
PubMed
Google Scholar
Hanssen E, Knoechel C, Dearnley M, Dixon MWA, Le Gros M, Larabell C, Tilley L: Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum. J Struct Biol. 2012, 177: 224-232. 10.1016/j.jsb.2011.09.003.
Article
PubMed Central
PubMed
Google Scholar
Aingaran M, Zhang R, Law SK, Peng Z, Undisz A, Meyer E, Diez-Silva M, Burke TA, Spielmann T, Lim CT, Suresh S, Dao M, Marti M: Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum. Cell Microbiol. 2012, 14: 983-993. 10.1111/j.1462-5822.2012.01786.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Adjalley SH, Johnston GL, Li T, Eastman RT, Ekland EH, Eappen AG, Richman A, Sim BKL, Lee MCS, Hoffman SL, Fidock DA: Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proc Natl Acad Sci U S A. 2011, 108: E1214-E1223. 10.1073/pnas.1112037108.
Article
PubMed Central
PubMed
Google Scholar
Saunders EC, Ng WW, Chamber JM, Ng M, Naderer T, Kroemer JO, Likic VA, McConville MJ: Isoptopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in TCA cycle anaplerosis, glutamate synthesis and growth. J Biol Chem. 2011, 286: 27706-27717. 10.1074/jbc.M110.213553.
Article
PubMed Central
CAS
PubMed
Google Scholar
Smalley ME, Sinden RE: Plasmodium falciparum gametocytes: their longevity and infectivity. Parasitology. 1977, 74: 1-8. 10.1017/S0031182000047478.
Article
CAS
PubMed
Google Scholar
del Pilar CM, Avery TD, Hanssen E, Fox E, Robinson TV, Valente P, Taylor DK, Tilley L: Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology. Antimicrob Agents Chemother. 2008, 52: 98-109. 10.1128/AAC.00609-07.
Article
Google Scholar
Jackson KE, Klonis N, Ferguson DJ, Adisa A, Dogovski C, Tilley L: Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum. Mol Microbiol. 2004, 54: 109-122. 10.1111/j.1365-2958.2004.04284.x.
Article
CAS
PubMed
Google Scholar
Adisa A, Rug M, Klonis N, Foley M, Cowman AF, Tilley L: The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites. J Biol Chem. 2003, 278: 6532-6542. 10.1074/jbc.M207039200.
Article
CAS
PubMed
Google Scholar
Seeber F, Limenitakis J, Soldati-Favre D: Apicomplexan mitochondrial metabolism: a story of gains, losses and retentions. Trends Parasitol. 2008, 24: 468-478. 10.1016/j.pt.2008.07.004.
Article
CAS
PubMed
Google Scholar
Danne JC, Gornik SG, Macrae JI, McConville MJ, Waller RF: Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans. Mol Biol Evol. 2012, 30: 123-139.
Article
PubMed
Google Scholar
Heath C, Posner MG, Aass HC, Upadhyay A, Scott DJ, Hough DW, Danson MJ: The 2-oxoacid dehydrogenase multi-enzyme complex of the archaeon Thermoplasma acidophilum – recombinant expression, assembly and characterization. FEBS J. 2007, 274: 5406-5415. 10.1111/j.1742-4658.2007.06067.x.
Article
CAS
PubMed
Google Scholar
Pettit FH, Yeaman SJ, Reed LJ: Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney. Proc Natl Acad Sci U S A. 1978, 75: 4881-4885. 10.1073/pnas.75.10.4881.
Article
PubMed Central
CAS
PubMed
Google Scholar
PlasmoDB.org
Wrenger C, Muller IB, Silber AM, Jordanova R, Lamzin VS, Groves MR: Aspartate aminotransferase: bridging carbohydrate and energy metabolism in Plasmodium falciparum. Curr Drug Metab. 2012, 13: 332-336. 10.2174/138920012799320400.
Article
CAS
PubMed
Google Scholar
Storm J, Perner J, Aparicio I, Patzewitz E-M, Olszewski K, Llinas M, Engel PC, Muller S: Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development. Malar J. 2011, 10: 193-10.1186/1475-2875-10-193.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fait A, Fromm H, Walter D, Galili G, Fernie AR: Highway or byway: the metabolic role of the GABA shunt in plants. Trends Plant Sci. 2008, 13: 14-19.
Article
CAS
PubMed
Google Scholar
White NJ, Warrell DA, Chanthavanich P, Looareesuwan S, Warrell MJ, Krishna S, Williamson DH, Turner RC: Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med. 1983, 309: 61-66. 10.1056/NEJM198307143090201.
Article
CAS
PubMed
Google Scholar
Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D, Winzeler EA, Mesirov JP, Regev A: Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007, 450: 1091-1095. 10.1038/nature06311.
Article
CAS
PubMed
Google Scholar
Talman AM, Domarle O, McKenzie FE, Ariey F, Robert V: Gametocytogenesis: the puberty of Plasmodium falciparum. Malar J. 2004, 3: 24-10.1186/1475-2875-3-24.
Article
PubMed Central
PubMed
Google Scholar
Elford BC, Haynes JD, Chulay JD, Wilson RJ: Selective stage-specific changes in the permeability to small hydrophilic solutes of human erythrocytes infected with Plasmodium falciparum. Mol Biochem Parasitol. 1985, 16: 43-60. 10.1016/0166-6851(85)90048-9.
Article
CAS
PubMed
Google Scholar
Kirk K, Horner HA, Elford BC, Ellory JC, Newbold CI: Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel. J Biol Chem. 1994, 269: 3339-3347.
CAS
PubMed
Google Scholar
Saul A, Graves P, Edser L: Refractoriness of erythrocytes infected with Plasmodium falciparum gametocytes to lysis by sorbitol. Int J Parasitol. 1990, 20: 1095-1097. 10.1016/0020-7519(90)90056-S.
Article
CAS
PubMed
Google Scholar
Lovegrove FE, Peña-Castillo L, Liles WC, Hughes TR, Kain KC: Plasmodium falciparum shows transcriptional versatility within the human host. Trends Parasitol. 2008, 24: 288-291. 10.1016/j.pt.2008.04.004.
Article
CAS
PubMed
Google Scholar
LeRoux M, Lakshmanan V, Daily JP: Plasmodium falciparum biology: analysis of in vitro versus in vivo growth conditions. Trends Parasitol. 2009, 25: 474-481. 10.1016/j.pt.2009.07.005.
Article
PubMed
Google Scholar
Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, Collins F, Doumbo OK, Greenwood B, Hall BF, Levine MM, Mendis K, Newman RD, Plowe CV, Rodríguez MH, Sinden R, Slutsker L, Tanner M: A research agenda to underpin malaria eradication. PLoS Med. 2011, 8: e1000406-10.1371/journal.pmed.1000406.
Article
PubMed Central
PubMed
Google Scholar
Stepniewska K, Price RN, Sutherland CJ, Drakeley CJ, von Seidlein L, Nosten F, White NJ: Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malar J. 2008, 7: 249-10.1186/1475-2875-7-249.
Article
PubMed Central
PubMed
Google Scholar
Dearnley MK, Yeoman JA, Hanssen E, Kenny S, Turnbull L, Whitchurch CB, Tilley L, Dixon MWA: Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes. J Cell Sci. 2012, 125: 2053-2063. 10.1242/jcs.099002.
Article
CAS
PubMed
Google Scholar
Zamboni N, Fendt SM, Ruhl M, Sauer U: (13)C-based metabolic flux analysis. Nat Protoc. 2009, 4: 878-892. 10.1038/nprot.2009.58.
Article
CAS
PubMed
Google Scholar
Lutz NW, Yahi N, Fantini J, Cozzone PJ: A new method for the determination of specific 13C enrichment in phosphorylated [1-13C]glucose metabolites. 13C-coupled, 1H-decoupled 31P-NMR spectroscopy of tissue perchloric acid extracts. Eur J Biochem. 1996, 238: 470-475. 10.1111/j.1432-1033.1996.0470z.x.
Article
CAS
PubMed
Google Scholar
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