An inside-out origin for the eukaryotic cell

Table 1 Homologies under three competing models for the origin of eukaryotes

Eukaryotic cell structure	Autogenous outside-in	Endosymbiotic outside-in	Inside-out
Inner nuclear membrane	Inner surface of fused ER lamellae	Plasma membrane of endosymbiont	Original plasma membrane
Perinuclear space	ER cisterna	Food vacuole	Footprint of the original cell wall
Outer nuclear membrane	Outer surface of fused ER lamellae	Food vacuole membrane	Inner surface of cytoplasmic blebs
ER	Internalized plasma membrane vesicles	Internalized plasma membrane vesicles	Space between extracellular blebs
Plasma membrane	Original plasma membrane	Original plasma membrane	Outer membrane of extracellular blebs

ISSN: 1741-7007