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Erratum to: Type IV collagen drives alveolar epithelial–endothelial association and the morphogenetic movements of septation

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BMC Biology201614:73

  • Published:

The original article was published in BMC Biology 2016 14:59


Unfortunately, the original version of this article [1] contained errors. Figure 1 was included incorrectly. The corrected Fig. 1 has been corrected in the original article and Fig. 1 is included correctly below.
Fig. 1
Fig. 1

Lung development timeline and type IV collagen expression in the chicken and the mouse. a Mouse and chicken lung development comparative timeline. b Microarray analysis shows that vascular related genes, among which are Col4a1 and Col4a2, show the highest significance in late chick lung development. c Real-time PCR shows differential expression of Col4a1 (blue) and Col4a2 (green) between E16 and E18 in chick lungs. Col4a1 and Col4a2 expression increases at E16 and E18, and is statistically significant (Wilcoxon rank-sum test P < 0.05) when compared to E14. Chicken G6PDH was used as a normalizer. di Type IV collagen protein and mRNA expression in the lung. dg COL4A1 protein is found throughout the lung interstitium and epithelium (arrows) in the prenatal (E18.5) and postnatal (P6, P30) lungs but mainly in the interstitium at E16.5. At P6 and P30 murine COL4A1 protein is found at the tips of secondary septa (arrowhead in FGF). hk Col4a1 mRNA is almost undetectable by in situ hybridization at E16.5 (h) and is later found in a patchy distribution throughout the interstitium (arrows in ik) with high expression at the tips of primary and secondary septa (arrowheads). Scale bar = 100 μm and applies to di

Additionally there are minor typographical errors stated below:

Additional file 3: Figure S3 has been revised: The image in the lefthand panel of the 3rd row of Additional file 3: Figure S3 (w/ y-axis labeled "PSPC PDPL") was wrong.

Page 4, second paragraph, third sentence: "week" should be "weak", and the figure panel mentioned last in that sentence should read, "(Fig. 1i-k), not g-i.

The correct sentence is below:

"Col4a1mRNA expression was very weak at epithelial tips and surrounding mesenchyme at E16.5 (Fig. 1 h), but later, at E18.5, P6, and P30, it was clearly found in the lung interstitium and at the tips of the developing septa (Fig. 1 i-k)."

Page 8, first paragraph, first sentence contains a split infinitive; it should read, "To show abnormalities more clearly in the development of type I pneumonocytes…".

Page 11, third paragraph, the word "defects" is missing, which alters the nuance, making this sentence confusing. The sentence should read: "The absence of branching defects may be because we analyzed heterozygous mutants in which sufficient levels of native protein…".



Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

The Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
Departments of Ophthalmology and Anatomy, Institute for Human Genetics, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
Department of Human Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA


  1. Loscertales M, Nicolaou F, Jeanne M, et al. BMC Biol. 2016;14:59. doi:10.1186/s12915-016-0281-2.


© The Author(s). 2016