- Open Access
Synaptopathy, circuitopathy and the computational biology of Huntington’s disease
© Hannan et al. 2018
- Published: 27 June 2018
Huntington’s disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively affects specific neuronal populations. A new article in BMC Biology provides a piece in the puzzle of pathogenesis. By demonstrating the delicate relationship between cortical and striatal neurons, it provokes broader questions of how we might understand HD as a disorder of synapses, neural circuits and systems biology.
AJH is an NHMRC Principal Research Fellow. The author’s laboratory is supported by NHMRC Project Grants, an ARC Discovery Project and the DHB Foundation, Equity Trustees.
The author wrote the text, generated the figure and read and approved the final manuscript.
The author declares that he has no competing interests.
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