Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes

Table 3 Expression level of some selected markers in EEC and PEC isolated from wild-type and pax6b^sa0086 mutant larvae

Markers	Gene	PEC wild type	PEC pax6b^−/−	EEC wild type	EEC pax6b^−/−
Epsilon PEC	*ghrl*	996	3156	184	876
	*mlnl*	7.6	385	785	4604
	*mboat4*	0.7	201	0.02	1.3
Beta PEC	*ins*	13,111	112	1.1	2.9
	*ndufa4l2a*	1729	82	1.8	1.2
	*nkx6.2*	330	10	5.5	7.7
	*pdx1*	1377	37	453	46
Delta PEC	*sst2*	24,070	6287	107	440
	*sst1.1*	668	37	27	0.2
	*sst1.2*	33,282	4375	89	37
	*lamc2*	153	16	4	31
	*nmba*	1640	110	46	15
	*hhex*	95	27	0.5	0.1
	*cdx4*	181	64	40	32
Alpha PEC	*gcgb*	15,002	42	179	2.4
	*gcga*	1776	3791	1982	1526
	*pnoca*	144	14	11	2.2
Alpha and epsilon	*scinlb*	83	1374	476	1365
Alpha and epsilon	*arxa*	67	290	42	57
EEC hormones	*galn*	0.05	0.19	758	12
	*pyyb*	32	20	34,323	3746
	*calca*	57	24	1933	349
	*adcyap1a*	0.58	0.41	6201	2672
	*vipb*	0.07	0.17	737	190
	*ccka*	0.43	1.01	6257	7212

The expression level (given in normalized CPM) was obtained from the RNA-seq data. The values are the expression mean of triplicate samples. Table S4 provides the expression level of all genes (values for each sample, means and standard deviation)

ISSN: 1741-7007