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Table 1 Meta-regression of potential moderators of housing effects on stress-sensitive disease

From: Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis

  Test statistic p
Species F1,154 = 0.2222 0.6381
Sex F2,154 = 0.0160 0.9841
Social status F2,154 = 0.6564 0.5201
Disease F4,154 = 1.3522 0.2532
Measure: infarct volume versus others F1,154 = 22.7385 <  0.0001
Species × sex F2,154 = 1.6491 0.1956
Species × social status F2,154 = 0.5794 0.5615
Sex × social status F4,154 = 0.6208 0.6484
Resource category F3,139 = 0.8280 0.4806
Resource category × species F3,139 = 1.0409 0.3766
After removal of ‘red flags’
Species F1,91 = 0.0351 0.8517
Sex F2,91 = 0.2542 0.7761
Social status F2,91 = 0.4339 0.6493
Disease F4,91 = 2.5952 0.0415
Measure: infarct volume versus others F1,91 = 15.8439 0.0001
Species × sex F2,91 = 0.9884 0.3761
Species × social status F2,91 = 0.9929 0.3745
Sex × social status F4,91 = 0.2229 0.9250
Resource category F3,83 = 2.5128 0.0641
Resource category × species F3,83 = 0.8890 0.4504
  1. Results from a random-effects meta-regression investigating potential moderators of housing effects (effects of conventional housing versus housing ‘enriched’ with resources supporting species-typical behaviour) on stress-sensitive disease (standardized mean differences). (See Additional file 10 for a replicate excluding study weights). Bold p values are significant at p < 0.05.