Table 2 Key characteristics distinguishing A and B SCN states
From: Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates
Character | State A | State B |
|---|---|---|
Stemness | Pluripotent at most | Totipotent (developing the soma/germ cell lineages). |
Regulation | At the SC level | At the entire organism/whole tissue levels |
Niche architecture | No. niche. Each ASC may sustain its own private self-regulation intimate environment | The entire organism/whole tissue constructions |
Level of molecular pursuit | Self-regulating (cancer cells, archaeocytes, choanocytes) | Systemic |
Motility of cells | Highly motile | Restricted motility |
Distribution | Random (archaeocytes, cancer cells) | More ordered in the animal milieu (sponge choanocytes, pinacocytes, I-cells in Hydra, neoblasts in flatworms) |