Fig. 5
Cell cycle and replication pattern of wild-type, pykAGD245/6AA and pykAT>D cells. Vertical red lines stand for three successive generations: grandmother: 0Ï„ to 1Ï„; mother: 1Ï„ to 2Ï„; daughter: 2Ï„ to 3Ï„; 28.4 min each). The C and D periods of cell cycles ending at time 1Ï„, 2Ï„, and 3Ï„ are indicated as lines and boxes colored in black, blue and yellow, respectively. The cell cycle in green will end at time 4Ï„ (not shown). Gray areas refer to replication periods spanning every cell cycle and numbers correspond to the proportion of cells in each period. Replication patterns typifying each period are given above the gray areas using the cell cycle color code. Ai: age of replication initiation; At: age of replication termination. Activity stand for pyruvate kinase activity