Table 2 Correlation pairs of firing rate (FR), tuning width, and best frequency features for each experimental group (NE hM4Di+ — animals exposed to noise expressing CaMKII α-hM4Di, n=11 mice; or NE+CNO hM4Di — animals exposed to noise under effect of CNO, expressing CaMKII α-hM4Di, n=6 mice) and each respective control (NE eYFP — animals exposed to noise expressing CaMKII α-eYFP, n=7 mice; or NE+CNO eYFP — animals exposed to noise under effect of CNO, expressing eYFP, n=6 mice) represented as Pearson correlation coefficient (r) and p-value for testing non-correlation (p). Unit responses are further subdivided based on the applied treatment (NaCl or CNO) and on the firing rate change under CNO in relation to NaCl treatment (All — all units; Decreased and Increased — units that show a decrease or an increase in firing rate under effect of CNO, respectively). All p values were Bonferroni-corrected for multiple comparisons
From: Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice
| Â | All | Decreased FR after CNO | Increased FR after CNO | |||
|---|---|---|---|---|---|---|
| Â | NaCl | CNO | NaCl | CNO | NaCl | CNO |
Firing rate x Best freq. (r, p) | ||||||
NE hM4Di+ | 0.064, 1.000 | 0.059, 1.000 | 0.085, 1.000 | -0.094, 1.000 | -0.031, 1.000 | 0.047, 1.000 |
NE eYFP | 0.164, 0.639 | 0.142, 1.000 | 0.119, 1.000 | 0.370, 0.053 | 0.067, 1.000 | -0.081, 1.000 |
NE+CNO hM4Di+ | -0.081, 1.000 | -0.024, 1.000 | 0.022, 1.000 | -0.061, 1.000 | -0.323, 0.058 | 0.007, 1.000 |
NE+CNO eYFP | 0.069, 1.000 | 0.023, 1.000 | 0.003, 1.000 | 0.229, 1.000 | 0.054, 1.000 | -0.224, 1.000 |
Firing rate x Tuning width (r, p) | ||||||
NE hM4Di+ | 0.479, 2.2e-7* | 0.352, 6.1e-4* | 0.504, 1.5e-6* | 0.264, 0.083 | 0.413, 0.324 | 0.484, 0.108 |
NE eYFP | 0.378, 1.6e-4* | 0.445, 2.5e-6* | 0.557, 1.1e-4* | 0.470, 3.0e-3* | 0.349, 3.2e-2* | 0.429, 2.3e-3* |
NE+CNO hM4Di+ | 0.045, 1.000 | 0.246, 5.3e-3* | 0.099, 1.000 | 0.293, 9.9e-3* | -0.109, 1.000 | 0.140, 1.000 |
NE+CNO eYFP | 0.470, 5.0e-5* | 0.481, 2.9e-5* | 0.469, 1.1e-2* | 0.390, 0.074 | 0.492, 2.4e-2* | 0.596, 1.4e-3* |
Tuning width X Best freq. (r, p) | ||||||
NE hM4Di+ | 0.301, 6.7e-3* | 0.352, 6.3e-4* | 0.201, 0.450 | 0.314, 1.6e-2* | 0.591, 1.4e-2* | 0.249, 1.000 |
NE eYFP | 0.198, 0.252 | 0.252, 4.7e-2* | 0.182, 1.000 | 0.138, 1.000 | 0.247, 0.378 | 0.263, 0.27 |
NE+CNO hM4Di+ | 0.069, 1.000 | 0.137, 0.522 | 0.064, 1.000 | 0.108, 1.000 | 0.086, 1.000 | 0.181, 1.000 |
NE+CNO eYFP | 0.068, 1.000 | 0.231, 0.306 | -0.110, 1.000 | 0.365, 0.126 | 0.223, 1.000 | 0.036, 1.000 |