Fig. 3

GO biological analysis on MM dataset. A GO biological process analysis on MM RNA-Seq data (n = 3 kidneys/genotype) was carried out with the ToppFun tool (application of ToppGene Suite). The figure shows the genes identified in our dataset in blue (0–600) and those within annotated functions in ToppFun in red (0–2000). B Heatmap analysis of the top four biological processes of MM RNA-Seq data. Genes related to cell cycle, intracellular protein transport, macromolecule catabolic processes, and protein localization to organelle have mostly opposite expression between control (green) and MAPK/ERK-deficient nephron progenitors (Dko, yellow). Detailed lists of all biological processes and the genes that make them up are provided in Additional file 4: Table S3