Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annu Rev Immunol. 2007;25:697–743.
Article
PubMed
CAS
Google Scholar
Buchon N, Silverman N, Cherry S. Immunity in Drosophila melanogaster--from microbial recognition to whole-organism physiology. Nat Rev Immunol. 2014;14(12):796–810.
Article
PubMed
CAS
PubMed Central
Google Scholar
Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, Oshima Y, Peach C, Erturk-Hasdemir D, Goldman WE, Oh BH, et al. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol. 2006;7(7):715–23.
Article
PubMed
CAS
Google Scholar
Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, et al. Peptidoglycan-sensing receptors trigger the formation of functional amyloids of the adaptor protein IMD to initiate Drosophila NF-kappaB signaling. Immunity. 2017;47(4):635–47. e636
Article
PubMed
CAS
PubMed Central
Google Scholar
Paquette N, Broemer M, Aggarwal K, Chen L, Husson M, Erturk-Hasdemir D, Reichhart JM, Meier P, Silverman N. Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell. 2010;37(2):172–82.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, Shaffer SA, Silverman N. Innate immune signaling in Drosophila is regulated by transforming growth factor beta (TGFbeta)-activated kinase (Tak1)-triggered ubiquitin editing. J Biol Chem. 2017;292(21):8738–49.
Article
PubMed
PubMed Central
CAS
Google Scholar
Stoven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, Engstrom Y, Maniatis T, Hultmark D. Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A. 2003;100(10):5991–6.
Article
PubMed
PubMed Central
CAS
Google Scholar
Rus F, Flatt T, Tong M, Aggarwal K, Okuda K, Kleino A, Yates E, Tatar M, Silverman N. Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity. EMBO J. 2013;32(11):1626–38.
Article
PubMed
PubMed Central
CAS
Google Scholar
Meister M, Richards G. Ecdysone and insect immunity: the maturation of the inducibility of the diptericine gene in Drosophila larvae. Insect Biochemistry Mol Biol. 1996;26:155–60.
Article
CAS
Google Scholar
Rauschenbach IY, Sukhanova MZ, Hirashima A, Sutsugu E, Kuano E. Role of the ecdysteroid system in the regulation of Drosophila reproduction under environmental stress. Dokl Biol Sci. 2000;375:641–3.
Article
PubMed
CAS
Google Scholar
Terashima J, Takaki K, Sakurai S, Bownes M. Nutritional status affects 20-hydroxyecdysone concentration and progression of oogenesis in Drosophila melanogaster. J Endocrinol. 2005;187(1):69–79.
Article
PubMed
CAS
Google Scholar
Ishimoto H, Kitamoto T. The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Genetics. 2010;185(1):269–81.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ishimoto H, Kitamoto T. Beyond molting--roles of the steroid molting hormone ecdysone in regulation of memory and sleep in adult Drosophila. Fly. 2011;5(3):215–20.
Article
PubMed
PubMed Central
CAS
Google Scholar
Dow JA. Insights into the Malpighian tubule from functional genomics. J Exp Biol. 2009;212(Pt 3):435–45.
Article
PubMed
CAS
Google Scholar
Nghiem D, Gibbs AG, Rose MR, Bradley TJ. Postponed aging and desiccation resistance in Drosophila melanogaster. Exp Gerontol. 2000;35(8):957–69.
Article
PubMed
CAS
Google Scholar
Gibbs AG, Markow TA. Effects of age on water balance in Drosophila species. Physiol Biochem Zool. 2001;74(4):520–30.
Article
PubMed
CAS
Google Scholar
Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA, Imler JL. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. 2000;13(5):737–48.
Article
PubMed
CAS
Google Scholar
McGettigan J, McLennan RK, Broderick KE, Kean L, Allan AK, Cabrero P, Regulski MR, Pollock VP, Gould GW, Davies SA, et al. Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochem Mol Biol. 2005;35(7):741–54.
Article
PubMed
CAS
Google Scholar
Kaneko T, Goldman WE, Mellroth P, Steiner H, Fukase K, Kusumoto S, Harley W, Fox A, Golenbock D, Silverman N. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity. 2004;20(5):637–49.
Article
PubMed
CAS
Google Scholar
Hoffmann JA. The immune response of Drosophila. Nature. 2003;426(6962):33–8.
Article
PubMed
CAS
Google Scholar
Werner T, Liu G, Kang D, Ekengren S, Steiner H, Hultmark D. A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci U S A. 2000;97(25):13772–7.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chang CI, Ihara K, Chelliah Y, Mengin-Lecreulx D, Wakatsuki S, Deisenhofer J. Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition. Proc Natl Acad Sci U S A. 2005;102(29):10279–84.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chang CI, Pili-Floury S, Herve M, Parquet C, Chelliah Y, Lemaitre B, Mengin-Lecreulx D, Deisenhofer J. A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. PLoS Biol. 2004;2(9):E277.
Article
PubMed
PubMed Central
CAS
Google Scholar
Schwedes CC, Carney GE. Ecdysone signaling in adult Drosophila melanogaster. J Insect Physiol. 2012;58(3):293–302.
Article
PubMed
CAS
Google Scholar
Dimarcq J-L, Imler J-L, Lanot R, Ezekowitz RAB, Hoffmann JA, Janeway CA, Lagueux M. Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression. Insect Biochem Mol Biol. 1997;27(10):877–86.
Article
PubMed
CAS
Google Scholar
Beckstead RB, Lam G, Thummel CS. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol. 2005;6(12):R99.
Article
PubMed
PubMed Central
CAS
Google Scholar
Silverman N, Zhou R, Stoven S, Pandey N, Hultmark D, Maniatis T. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 2000;14(19):2461–71.
Article
PubMed
PubMed Central
CAS
Google Scholar
Flatt T, Heyland A, Rus F, Porpiglia E, Sherlock C, Yamamoto R, Garbuzov A, Palli SR, Tatar M, Silverman N. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol. 2008;211(Pt 16):2712–24.
Article
PubMed
PubMed Central
CAS
Google Scholar
Koelle MR, Talbot WS, Segraves WA, Bender MT, Cherbas P, Hogness DS. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell. 1991;67(1):59–77.
Article
PubMed
CAS
Google Scholar
Schwedes C, Tulsiani S, Carney GE. Ecdysone receptor expression and activity in adult Drosophila melanogaster. J Insect Physiol. 2011;57(7):899–907.
Article
PubMed
CAS
Google Scholar
Simon AF, Shih C, Mack A, Benzer S. Steroid control of longevity in Drosophila melanogaster. Science. 2003;299:1407–10.
Article
PubMed
CAS
Google Scholar
Ishimoto H, Wang Z, Rao Y, Wu CF, Kitamoto T. A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain. PLoS Genet. 2013;9(10):e1003843.
Article
PubMed
PubMed Central
CAS
Google Scholar
Belles X, Piulachs MD. Ecdysone signalling and ovarian development in insects: from stem cells to ovarian follicle formation. Biochim Biophys Acta. 2015;1849(2):181–6.
Article
PubMed
CAS
Google Scholar
Pletcher S, Macdononald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB, Partridge L. Genome_wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol. 2002;12:712–23.
Article
PubMed
CAS
Google Scholar
Zerofsky M, Harel E, Silverman N, Tatar M. Aging of the innate immune response in Drosophila melanogaster. Aging Cell. 2005;4(2):103–8.
Article
PubMed
CAS
Google Scholar
Landis GN, Abdueva D, Skvortsov D, Yang J, Rabin BE, Carrick J, Tavare S, Tower J. Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2004;101:7663–8.
Article
PubMed
PubMed Central
CAS
Google Scholar
Schneider DS, Ayres JS. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol. 2008;8(11):889–95.
Article
PubMed
PubMed Central
CAS
Google Scholar
Fan Y, Borovsky D, Hawkings C, Ortiz-Urquiza A, Keyhani NO. Exploiting host molecules to augment mycoinsecticide. Virulence. 2012;30(1):37.
Google Scholar
Rera M, Clark RI, Walker DW. Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci U S A. 2012;109(52):21528–33.
Article
PubMed
PubMed Central
Google Scholar
Guo L, Karpac J, Tran SL, Jasper H. PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan. Cell. 2014;156(1–2):109–22.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang Y, Lu YX, Liu J, Yang C, Feng QL, Xu WH. A regulatory pathway, ecdysone-transcription factor relish-cathepsin L, is involved in insect fat body dissociation. PLoS Genet. 2013;9(2):e1003273.
Article
PubMed
PubMed Central
CAS
Google Scholar
Terhzaz S, Cabrero P, Robben JH, Radford JC, Hudson BD, Milligan G, Dow JA, Davies SA. Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS One. 2012;7(1):e29897.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kean L, Cazenave W, Costes L, Broderick KE, Graham S, Pollock VP, Davies SA, Veenstra JA, Dow JA. Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol. 2002;282(5):R1297–307.
Article
PubMed
CAS
Google Scholar
Kahsai L, Kapan N, Dircksen H, Winther AM, Nassel DR. Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides. PLoS One. 2010;5(7):e11480.
Article
PubMed
PubMed Central
CAS
Google Scholar
Soderberg JA, Birse RT, Nassel DR. Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance. PLoS One. 2011;6(5):e19866.
Article
PubMed
PubMed Central
CAS
Google Scholar
Smith WA, Lamattina A, Collins M. Insulin signaling pathways in lepidopteran ecdysone secretion. Front Physiol. 2014;5:19.
PubMed
PubMed Central
Google Scholar
Colombani J, Bianchini L, Layalle S, Pondeville E, Dauphin-Villemant C, Antoniewski C, Carre C, Noselli S, Leopold P. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science. 2005;310(5748):667–70.
Article
PubMed
CAS
Google Scholar
Mirth C. Ecdysteroid control of metamorphosis in the differentiating adult leg structures of Drosophila melanogaster. Dev Biol. 2005;278(1):163–74.
Article
PubMed
CAS
Google Scholar
Truman JW, Riddiford LM. Endocrine insights into the evolution of metamorphosis in insects. Annu Rev Entomol. 2002;47:467–500.
Article
PubMed
CAS
Google Scholar
Buszczak M, Freeman MR, Carlson JR, Bender M, Cooley L, Segraves WA. Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development. 1999;126(20):4581–9.
PubMed
CAS
Google Scholar
Rewitz KF, Rybczynski R, Warren JT, Gilbert LI. Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol. 2006;36(3):188–99.
Article
PubMed
CAS
Google Scholar
Hentze JL, Moeller ME, Jorgensen AF, Bengtsson MS, Bordoy AM, Warren JT, Gilbert LI, Andersen O, Rewitz KF. Accessory gland as a site for prothoracicotropic hormone controlled ecdysone synthesis in adult male insects. PLoS One. 2013;8(2):e55131.
Article
PubMed
PubMed Central
CAS
Google Scholar
Handler AM. Ecdysteroid titers during pupal and adult development in Drosophila melanogaster. Dev Biol. 1982;93(1):73–82.
Article
PubMed
CAS
Google Scholar
Ishimoto H, Sakai T, Kitamoto T. Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Proc Natl Acad Sci U S A. 2009;106(15):6381–6.
Article
PubMed
PubMed Central
Google Scholar
Tricoire H, Battisti V, Trannoy S, Lasbleiz C, Pret AM, Monnier V. The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner. Mech Ageing Dev. 2009;130(8):547–52.
Article
PubMed
CAS
Google Scholar
Service PM, Huthinson EW, Mackinley MD, Rose MR. Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol Zool. 1985;58(4):380–9.
Article
Google Scholar
Drapeau MD, Gass EK, Simison MD, Mueller LD, Rose MR. Testing the heterogeneity theory of late-life mortality plateaus by using cohorts of Drosophila melanogaster. Exp Gerontol. 2000;35(1):71–84.
Article
PubMed
CAS
Google Scholar
Gibbs A, Mousseau TA, Crowe JH. Genetic and acclimatory variation in biophysical properties of insect cuticle lipids. Proc Natl Acad Sci USA. 1991;88:7257–60.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kuo TH, Yew JY, Fedina TY, Dreisewerd K, Dierick HA, Pletcher SD. Aging modulates cuticular hydrocarbons and sexual attractiveness in Drosophila melanogaster. J Exp Biol. 2012;215(Pt 5):814–21.
Article
PubMed
PubMed Central
CAS
Google Scholar
Libert S, Chao Y, Chu X, Pletcher SD. Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell. 2006;5(6):533–43.
Article
PubMed
CAS
Google Scholar
Schwenke RA, Lazzaro BP, Wolfner MF. Reproduction-immunity trade-offs in insects. Annu Rev Entomol. 2016;61:239–56.
Article
PubMed
CAS
Google Scholar
Geiss GK, Bumgarner RE, Birditt B, Dahl T, Dowidar N, Dunaway DL, Fell HP, Ferree S, George RD, Grogan T, et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol. 2008;26(3):317–25.
Article
PubMed
CAS
Google Scholar
Hackney JF, Zolali-Meybodi O, Cherbas P. Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila. PLoS One. 2012;7(11):e49105.
Article
PubMed
PubMed Central
CAS
Google Scholar
Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci U S A. 2000;97(7):3376–81.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zaidman-Remy A, Herve M, Poidevin M, Pili-Floury S, Kim MS, Blanot D, Oh BH, Ueda R, Mengin-Lecreulx D, Lemaitre B. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity. 2006;24(4):463–73.
Article
PubMed
CAS
Google Scholar