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Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
© The Author(s). 2019
- Published: 20 February 2019
The original article was published in BMC Biology 2018 16:149
A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 that cause immunodeficiency are unable to form these structures. By contrast a somatic mutant that promotes the survival of tumour cells forms oligomers much more readily than the wild-type protein. These findings suggest that assembly of oligomeric MyD88 is critical for the regulation of inflammatory signalling.
Wellcome Trust Investigator award (WT100321/z/12/) to NJG.
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NJG wrote the commentary, and read and approved the final version.
The author declares that he has no competing interests.
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