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  1. Research article

    C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility

    In addition to DNA, gametes contribute epigenetic information in the form of histones and non-coding RNA. Epigenetic programs often respond to stressful environmental conditions and provide a heritable history...

    Wendy L. Johnston, Aldis Krizus, Arun K. Ramani, Wade Dunham, Ji Young Youn, Andrew G. Fraser, Anne-Claude Gingras and James W. Dennis

    BMC Biology 2017 15:61

    Published on: 17 July 2017

  2. Review

    Life behind the wall: sensing mechanical cues in plants

    There is increasing evidence that all cells sense mechanical forces in order to perform their functions. In animals, mechanotransduction has been studied during the establishment of cell polarity, fate, and di...

    Olivier Hamant and Elizabeth S. Haswell

    BMC Biology 2017 15:59

    Published on: 11 July 2017

  3. Question and Answer

    Q&A: using Patch-seq to profile single cells

    Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensi...

    Cathryn R. Cadwell, Rickard Sandberg, Xiaolong Jiang and Andreas S. Tolias

    BMC Biology 2017 15:58

    Published on: 6 July 2017

  4. Research article

    Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

    The aggregation of the protein ɑ-synuclein (ɑS) underlies a range of increasingly common neurodegenerative disorders including Parkinson’s disease. One widely explored therapeutic strategy for these conditions...

    Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, Craig D. Hughes, Francesco S. Ruggeri, Tim Guilliams, Alexander K. Buell, Ji-Eun Lee, Sonia Gandhi, Steven F. Lee, Clare E. Bryant, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson…

    BMC Biology 2017 15:57

    Published on: 3 July 2017

  5. Research article

    Evolution of strigolactone receptors by gradual neo-functionalization of KAI2 paralogues

    Strigolactones (SLs) are a class of plant hormones that control many aspects of plant growth. The SL signalling mechanism is homologous to that of karrikins (KARs), smoke-derived compounds that stimulate seed ...

    Rohan Bythell-Douglas, Carl J. Rothfels, Dennis W. D. Stevenson, Sean W. Graham, Gane Ka-Shu Wong, David C. Nelson and Tom Bennett

    BMC Biology 2017 15:52

    Published on: 29 June 2017

  6. Review

    Tissue macrophages: heterogeneity and functions

    Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes with...

    Siamon Gordon and Annette Plüddemann

    BMC Biology 2017 15:53

    Published on: 29 June 2017

  7. Research article

    Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain

    Moloney leukemia virus 10 (Mov10) is an RNA helicase that mediates access of the RNA-induced silencing complex to messenger RNAs (mRNAs). Until now, its role as an RNA helicase and as a regulator of retrotrans...

    Geena Skariah, Joseph Seimetz, Miles Norsworthy, Monica C. Lannom, Phillip J. Kenny, Mohamed Elrakhawy, Craig Forsthoefel, Jenny Drnevich, Auinash Kalsotra and Stephanie Ceman

    BMC Biology 2017 15:54

    Published on: 29 June 2017

  8. Forum

    Non-model model organisms

    Model organisms are widely used in research as accessible and convenient systems to study a particular area or question in biology. Traditionally only a handful of organisms have been widely studied, but moder...

    James J. Russell, Julie A. Theriot, Pranidhi Sood, Wallace F. Marshall, Laura F. Landweber, Lillian Fritz-Laylin, Jessica K. Polka, Snezhana Oliferenko, Therese Gerbich, Amy Gladfelter, James Umen, Magdalena Bezanilla, Madeline A. Lancaster, Shuonan He, Matthew C. Gibson, Bob Goldstein…

    BMC Biology 2017 15:55

    Published on: 29 June 2017

  9. Comment

    Organelle acidification: an ancient cellular leak detector

    Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of car...

    Mukund Thattai

    BMC Biology 2017 15:51

    Published on: 26 June 2017

  10. Question and Answer

    Q&A: Expansion microscopy

    Expansion microscopy (ExM) is a recently invented technology that uses swellable charged polymers, synthesized densely and with appropriate topology throughout a preserved biological specimen, to physically ma...

    Ruixuan Gao, Shoh M. Asano and Edward S. Boyden

    BMC Biology 2017 15:50

    Published on: 19 June 2017

  11. Editorial

    Who needs registered reports?

    Registered Reports, an article format initiated to help promote transparency and reproducibility in the preclinical and social sciences, are spreading into the biological literature. The format is now offered by

    Miranda Robertson

    BMC Biology 2017 15:49

    Published on: 15 June 2017

  12. Research article

    Matriptase zymogen supports epithelial development, homeostasis and regeneration

    Matriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammato...

    Stine Friis, Daniel Tadeo, Sylvain M. Le-Gall, Henrik Jessen Jürgensen, Katiuchia Uzzun Sales, Eric Camerer and Thomas H. Bugge

    BMC Biology 2017 15:46

    Published on: 1 June 2017

  13. Methodology article

    Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

    Intravascular leukocyte recruitment in most vertebrate tissues is restricted to postcapillary and collecting venules, whereas capillaries and arterioles usually support little or no leukocyte adhesion. This se...

    Aude Thiriot, Carolina Perdomo, Guiying Cheng, Igor Novitzky-Basso, Sara McArdle, Jamie K. Kishimoto, Olga Barreiro, Irina Mazo, Robinson Triboulet, Klaus Ley, Antal Rot and Ulrich H. von Andrian

    BMC Biology 2017 15:45

    Published on: 19 May 2017

  14. Methodology article

    Cell fixation and preservation for droplet-based single-cell transcriptomics

    Recent developments in droplet-based microfluidics allow the transcriptional profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way. A critical, often limiting ste...

    Jonathan Alles, Nikos Karaiskos, Samantha D. Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks and Nikolaus Rajewsky

    BMC Biology 2017 15:44

    Published on: 19 May 2017

  15. Research article

    Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

    Endogenous circadian oscillators distributed across the mammalian body are synchronised among themselves and with external time via a variety of signalling molecules, some of which interact with G-protein-coup...

    Helena J. Bailes, Nina Milosavljevic, Ling-Yu Zhuang, Elliot J. Gerrard, Tomoki Nishiguchi, Takeaki Ozawa and Robert J. Lucas

    BMC Biology 2017 15:40

    Published on: 15 May 2017

  16. Commentary

    Knowing where the nose is

    Improvements in imaging technology and the development of powerful machine learning algorithms are revolutionizing the study of animal behavior in the laboratory. These innovations promise to reveal both globa...

    Winthrop F. Gillis and Sandeep R. Datta

    BMC Biology 2017 15:42

    Published on: 15 May 2017

  17. Research article

    Heterosis as a consequence of regulatory incompatibility

    The merging of genomes in inter-specific hybrids can result in novel phenotypes, including increased growth rate and biomass yield, a phenomenon known as heterosis. Heterosis is typically viewed as the opposit...

    Rebecca H. Herbst, Dana Bar-Zvi, Sharon Reikhav, Ilya Soifer, Michal Breker, Ghil Jona, Eyal Shimoni, Maya Schuldiner, Avraham A. Levy and Naama Barkai

    BMC Biology 2017 15:38

    Published on: 11 May 2017

  18. Research article

    Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors

    Plant-pathogenic oomycetes are responsible for economically important losses in crops worldwide. Phytophthora palmivora, a tropical relative of the potato late blight pathogen, causes rotting diseases in many tro...

    Edouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, Clément Quan, Temur Yunusov, Kévin Floch and Sebastian Schornack

    BMC Biology 2017 15:39

    Published on: 11 May 2017

  19. Comment

    Can a biologist fix a smartphone?—Just hack it!

    Biological systems integrate multiscale processes and networks and are, therefore, viewed as difficult to dissect. However, because of the clear-cut separation between the software code (the information encode...

    Sophien Kamoun

    BMC Biology 2017 15:37

    Published on: 8 May 2017

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