Skip to main content

Articles

Page 2 of 33

  1. Experimental reproducibility in mouse models is impacted by both genetics and environment. The generation of reproducible data is critical for the biomedical enterprise and has become a major concern for the s...

    Authors: Rabindra K. Mandal, Joshua E. Denny, Morgan L. Waide, Qingsheng Li, Neal Bhutiani, Charles D. Anderson, Becca V. Baby, Venkatakrishna R. Jala, Nejat K. Egilmez and Nathan W. Schmidt

    Citation: BMC Biology 2020 18:83

    Content type: Research article

    Published on:

  2. Sex chromosomes have evolved independently multiple times in eukaryotes and are therefore considered a prime example of convergent genome evolution. Sex chromosomes are known to emerge after recombination is h...

    Authors: Pedro Almeida, Estelle Proux-Wera, Allison Churcher, Lucile Soler, Jacques Dainat, Pascal Pucholt, Jessica Nordlund, Tom Martin, Ann-Christin Rönnberg-Wästljung, Björn Nystedt, Sofia Berlin and Judith E. Mank

    Citation: BMC Biology 2020 18:78

    Content type: Research article

    Published on:

  3. Eukaryotic gene expression is controlled by a number of RNA-binding proteins (RBP), such as the proteins from the Puf (Pumilio and FBF) superfamily (PufSF). These proteins bind to RNA via multiple Puf repeat d...

    Authors: Vladimíra Najdrová, Courtney W. Stairs, Martina Vinopalová, Luboš Voleman and Pavel Doležal

    Citation: BMC Biology 2020 18:77

    Content type: Research article

    Published on:

  4. Lymphocytes circulate between peripheral lymphoid tissues via blood and lymphatic systems, and chemokine-induced migration is important in trafficking lymphocytes to distant sites. The small GTPase Rap1 is imp...

    Authors: Sayaka Ishihara, Tsuyoshi Sato, Guangwei Du, Daniele Guardavaccaro, Akihiko Nakajima, Satoshi Sawai, Tohru Kataoka and Koko Katagiri

    Citation: BMC Biology 2020 18:75

    Content type: Research article

    Published on:

  5. Copy number variations (CNVs) are an important type of structural variations in the genome that usually affect gene expression levels by gene dosage effect. Understanding CNVs as part of genome evolution may p...

    Authors: Fengli Zhao, Yuexing Wang, Jianshu Zheng, Yanling Wen, Minghao Qu, Shujing Kang, Shigang Wu, Xiaojuan Deng, Kai Hong, Sanfeng Li, Xing Qin, Zhichao Wu, Xiaobo Wang, Cheng Ai, Alun Li, Longjun Zeng…

    Citation: BMC Biology 2020 18:73

    Content type: Research article

    Published on:

  6. Age-associated DNA methylation changes provide a promising biomarker for the aging process. While genome-wide DNA methylation profiles enable robust age-predictors by integration of many age-associated CG dinu...

    Authors: Yang Han, Julia Franzen, Thomas Stiehl, Michael Gobs, Chao-Chung Kuo, Miloš Nikolić, Jan Hapala, Barbara Elisabeth Koop, Klaus Strathmann, Stefanie Ritz-Timme and Wolfgang Wagner

    Citation: BMC Biology 2020 18:71

    Content type: Methodology article

    Published on:

  7. Fleas (Insecta: Siphonaptera) are small flightless parasites of birds and mammals; their blood-feeding can transmit many serious pathogens (i.e., the etiological agents of bubonic plague, endemic and murine ty...

    Authors: Timothy P. Driscoll, Victoria I. Verhoeve, Joseph J. Gillespie, J. Spencer Johnston, Mark L. Guillotte, Kristen E. Rennoll-Bankert, M. Sayeedur Rahman, Darren Hagen, Christine G. Elsik, Kevin R. Macaluso and Abdu F. Azad

    Citation: BMC Biology 2020 18:70

    Content type: Research article

    Published on:

  8. A unifying feature of the bacterial Candidate Phyla Radiation (CPR) is a limited and highly variable repertoire of biosynthetic capabilities. However, the distribution of metabolic traits across the CPR and th...

    Authors: Alexander L. Jaffe, Cindy J. Castelle, Paula B. Matheus Carnevali, Simonetta Gribaldo and Jillian F. Banfield

    Citation: BMC Biology 2020 18:69

    Content type: Research article

    Published on:

  9. Plants have evolved a panoply of specialized metabolites that increase their environmental fitness. Two examples are caffeine, a purine psychotropic alkaloid, and crocins, a group of glycosylated apocarotenoid...

    Authors: Zhichao Xu, Xiangdong Pu, Ranran Gao, Olivia Costantina Demurtas, Steven J. Fleck, Michaela Richter, Chunnian He, Aijia Ji, Wei Sun, Jianqiang Kong, Kaizhi Hu, Fengming Ren, Jiejie Song, Zhe Wang, Ting Gao, Chao Xiong…

    Citation: BMC Biology 2020 18:63

    Content type: Research article

    Published on:

  10. The homeobox genes Pdx and Cdx are widespread across the animal kingdom and part of the small ParaHox gene cluster. Gene expression patterns suggest ancient roles for Pdx and Cdx in patterning the through-gut of ...

    Authors: Yanhong Zhong, Carlos Herrera-Úbeda, Jordi Garcia-Fernàndez, Guang Li and Peter W. H. Holland

    Citation: BMC Biology 2020 18:68

    Content type: Research article

    Published on:

  11. Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses...

    Authors: Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek and Dominique Soldati-Favre

    Citation: BMC Biology 2020 18:67

    Content type: Research article

    Published on:

  12. Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and in...

    Authors: Florence Kermen, Lea Darnet, Christoph Wiest, Fabrizio Palumbo, Jack Bechert, Ozge Uslu and Emre Yaksi

    Citation: BMC Biology 2020 18:66

    Content type: Research article

    Published on:

  13. CRISPR-Cas systems, which provide adaptive immunity against foreign nucleic acids in prokaryotes, can serve as useful molecular tools for multiple applications in genome engineering. Diverse CRISPR-Cas systems...

    Authors: Donata Tuminauskaite, Danguole Norkunaite, Marija Fiodorovaite, Sarunas Tumas, Inga Songailiene, Giedre Tamulaitiene and Tomas Sinkunas

    Citation: BMC Biology 2020 18:65

    Content type: Research article

    Published on:

  14. β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α4β7 binds MAdCAM-1, mediating rolling adhesion of lymphoc...

    Authors: Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng and Jianfeng Chen

    Citation: BMC Biology 2020 18:64

    Content type: Research article

    Published on:

  15. Parkinson’s disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their f...

    Authors: Federico Baldini, Johannes Hertel, Estelle Sandt, Cyrille C. Thinnes, Lorieza Neuberger-Castillo, Lukas Pavelka, Fay Betsou, Rejko Krüger and Ines Thiele

    Citation: BMC Biology 2020 18:62

    Content type: Research article

    Published on:

  16. Human-resident microbes can influence both health and disease. Investigating the microbiome using next-generation sequencing technology has revealed examples of mutualism and conflict between microbes and huma...

    Authors: Ryuichi Kumata, Jumpei Ito, Kenta Takahashi, Tadaki Suzuki and Kei Sato

    Citation: BMC Biology 2020 18:55

    Content type: Research article

    Published on:

  17. Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through ...

    Authors: Youngkyung Cho, Sang Bum Kim, Jiyoon Kim, An Vuong Quynh Pham, Min Ji Yoon, Jeong Hwan Park, Ki-Tae Hwang, Dongeun Park, Yongcheol Cho, Moon Gyo Kim and Chungho Kim

    Citation: BMC Biology 2020 18:60

    Content type: Research article

    Published on:

  18. Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington’s disease (HD), the c...

    Authors: S. Fernández-García, J. G. Orlandi, G. A. García-Díaz Barriga, M. J. Rodríguez, M. Masana, J. Soriano and J. Alberch

    Citation: BMC Biology 2020 18:58

    Content type: Research article

    Published on:

  19. Gene duplication events play an important role in the evolution and adaptation of organisms. Duplicated genes can arise through different mechanisms, including whole-genome duplications (WGDs). Recently, WGD w...

    Authors: Dick Roelofs, Arthur Zwaenepoel, Tom Sistermans, Joey Nap, Andries A. Kampfraath, Yves Van de Peer, Jacintha Ellers and Ken Kraaijeveld

    Citation: BMC Biology 2020 18:57

    Content type: Research article

    Published on:

  20. Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis ...

    Authors: Timothy G. Stephens, Raúl A. González-Pech, Yuanyuan Cheng, Amin R. Mohamed, David W. Burt, Debashish Bhattacharya, Mark A. Ragan and Cheong Xin Chan

    Citation: BMC Biology 2020 18:56

    Content type: Research article

    Published on:

  21. The cline of human genetic diversity observable across Europe is recapitulated at a micro-geographic scale by variation within the Italian population. Besides resulting from extensive gene flow, this might be ...

    Authors: Marco Sazzini, Paolo Abondio, Stefania Sarno, Guido Alberto Gnecchi-Ruscone, Matteo Ragno, Cristina Giuliani, Sara De Fanti, Claudia Ojeda-Granados, Alessio Boattini, Julien Marquis, Armand Valsesia, Jerome Carayol, Frederic Raymond, Chiara Pirazzini, Elena Marasco, Alberto Ferrarini…

    Citation: BMC Biology 2020 18:51

    Content type: Research article

    Published on:

  22. For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been ...

    Authors: John J. Wright, Justin G. Fedor, Judy Hirst and Maxie M. Roessler

    Citation: BMC Biology 2020 18:54

    Content type: Research article

    Published on:

  23. Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translationa...

    Authors: Christopher Stephen Thom, Chintan D Jobaliya, Kimberly Lorenz, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French and Benjamin Franklin Voight

    Citation: BMC Biology 2020 18:52

    Content type: Research article

    Published on:

  24. The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and con...

    Authors: Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari and John M. Marshall

    Citation: BMC Biology 2020 18:50

    Content type: Research article

    Published on:

  25. Mitochondria are essential organelles partially regulated by their own genomes. The mitochondrial genome maintenance and inheritance differ from the nuclear genome, potentially uncoupling their evolutionary tr...

    Authors: Matteo De Chiara, Anne Friedrich, Benjamin Barré, Michael Breitenbach, Joseph Schacherer and Gianni Liti

    Citation: BMC Biology 2020 18:49

    Content type: Research article

    Published on:

  26. Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largel...

    Authors: Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco…

    Citation: BMC Biology 2020 18:47

    Content type: Research article

    Published on:

  27. One hundred years ago, marine organisms were the dominant systems for the study of developmental biology. The challenges in rearing these organisms outside of a marine setting ultimately contributed to a shift...

    Authors: Jonathan Q. Henry, Maryna P. Lesoway and Kimberly J. Perry

    Citation: BMC Biology 2020 18:46

    Content type: Methodology article

    Published on:

  28. The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experie...

    Authors: Elizabeth A. O’Brien, Kathleen S. Ensbey, Bryan W. Day, Paul A. Baldock and Guy Barry

    Citation: BMC Biology 2020 18:45

    Content type: Research article

    Published on:

  29. Upon water uptake and release of seed dormancy, embryonic plant cells expand, while being mechanically constrained by the seed coat. Cortical microtubules (CMTs) are key players of cell elongation in plants: t...

    Authors: Huifang Yan, Nicole Chaumont, Jean François Gilles, Susanne Bolte, Olivier Hamant and Christophe Bailly

    Citation: BMC Biology 2020 18:44

    Content type: Research article

    Published on:

  30. In fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase since oriC ne...

    Authors: Alfonso Soler-Bistué, Sebastián Aguilar-Pierlé, Marc Garcia-Garcerá, Marie-Eve Val, Odile Sismeiro, Hugo Varet, Rodrigo Sieira, Evelyne Krin, Ole Skovgaard, Diego J. Comerci, Eduardo P. C. Rocha and Didier Mazel

    Citation: BMC Biology 2020 18:43

    Content type: Research article

    Published on:

  31. Many long noncoding RNAs (lncRNAs) have been implicated in general and cell type-specific molecular regulation. Here, we asked what underlies the fundamental basis for the seemingly random appearance of nuclea...

    Authors: Markus Grosch, Sebastian Ittermann, Ejona Rusha, Tobias Greisle, Chaido Ori, Dong-Jiunn Jeffery Truong, Adam C. O’Neill, Anna Pertek, Gil Gregor Westmeyer and Micha Drukker

    Citation: BMC Biology 2020 18:42

    Content type: Research article

    Published on:

  32. 5-Methylcytosine (m5C) is a prevalent base modification in tRNA and rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it serves incompletely understood molecular functions. In pu...

    Authors: Ulrike Schumann, He-Na Zhang, Tennille Sibbritt, Anyu Pan, Attila Horvath, Simon Gross, Susan J. Clark, Li Yang and Thomas Preiss

    Citation: BMC Biology 2020 18:40

    Content type: Research article

    Published on:

  33. The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple c...

    Authors: Tess Cherlin, Rogan Magee, Yi Jing, Venetia Pliatsika, Phillipe Loher and Isidore Rigoutsos

    Citation: BMC Biology 2020 18:38

    Content type: Research article

    Published on:

  34. The origin of animals from their unicellular ancestor was one of the most important events in evolutionary history, but the nature and the order of events leading up to the emergence of multicellular animals a...

    Authors: Denis V. Tikhonenkov, Elisabeth Hehenberger, Anton S. Esaulov, Olga I. Belyakova, Yuri A. Mazei, Alexander P. Mylnikov and Patrick J. Keeling

    Citation: BMC Biology 2020 18:39

    Content type: Research article

    Published on:

  35. Metagenomics studies leverage genomic reference databases to generate discoveries in basic science and translational research. However, current microbial studies use disparate reference databases that lack con...

    Authors: Caitlin Loeffler, Aaron Karlsberg, Lana S. Martin, Eleazar Eskin, David Koslicki and Serghei Mangul

    Citation: BMC Biology 2020 18:37

    Content type: Comment

    Published on:

    The Correction to this article has been published in BMC Biology 2020 18:92

  36. Base-excision repair (BER) is a central DNA repair mechanism responsible for the maintenance of genome integrity. Accordingly, BER defects have been implicated in cancer, presumably by precipitating cellular t...

    Authors: Elena Clementi, Larissa Inglin, Erin Beebe, Corina Gsell, Zuzana Garajova and Enni Markkanen

    Citation: BMC Biology 2020 18:36

    Content type: Research article

    Published on:

  37. The traditional view of protein aggregation as being strictly disease-related has been challenged by many examples of cellular aggregates that regulate beneficial biological functions. When coupled with the em...

    Authors: Giulio Chiesa, Szilvia Kiriakov and Ahmad S. Khalil

    Citation: BMC Biology 2020 18:35

    Content type: Review

    Published on:

  38. The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterat...

    Authors: Nina Strah, Giulia Romano, Clelia Introna, Raffaella Klima, Marta Marzullo, Laura Ciapponi, Aram Megighian, Monica Nizzardo and Fabian Feiguin

    Citation: BMC Biology 2020 18:34

    Content type: Research article

    Published on:

  39. Current therapies for multiple myeloma (MM) are associated with toxicity and resistance, highlighting the need for novel effective therapeutics. Berberine (BBR), a botanical alkaloid derived from several Berbe...

    Authors: Chunming Gu, Zhao Yin, Hong Nie, Yanjun Liu, Juhua Yang, Guiping Huang, Jianping Shen, Liguo Chen and Jia Fei

    Citation: BMC Biology 2020 18:33

    Content type: Research article

    Published on:

  40. Nuclear factor-κB (NF-κB) plays a prominent role in promoting inflammation and resistance to DNA damaging therapy. We searched for proteins that modulate the NF-κB response as a prerequisite to identifying nov...

    Authors: Szymon J. Szymura, Giovanna M. Bernal, Longtao Wu, Zhongqin Zhang, Clayton D. Crawley, David J. Voce, Paige-Ashley Campbell, Diana E. Ranoa, Ralph R. Weichselbaum and Bakhtiar Yamini

    Citation: BMC Biology 2020 18:32

    Content type: Research article

    Published on:

  41. Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identi...

    Authors: Yu Toyoshima, Stephen Wu, Manami Kanamori, Hirofumi Sato, Moon Sun Jang, Suzu Oe, Yuko Murakami, Takayuki Teramoto, Chanhyun Park, Yuishi Iwasaki, Takeshi Ishihara, Ryo Yoshida and Yuichi Iino

    Citation: BMC Biology 2020 18:30

    Content type: Methodology article

    Published on:

  42. Metabolic activity alternates between high and low states during different stages of an organism’s life cycle. During the transition from growth to quiescence, a major metabolic shift often occurs from oxidati...

    Authors: Sider Penkov, Bharath Kumar Raghuraman, Cihan Erkut, Jana Oertel, Roberta Galli, Eduardo Jacobo Miranda Ackerman, Daniela Vorkel, Jean-Marc Verbavatz, Edmund Koch, Karim Fahmy, Andrej Shevchenko and Teymuras V. Kurzchalia

    Citation: BMC Biology 2020 18:31

    Content type: Research article

    Published on:

Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.