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  1. Content type: Research article

    High throughput methods for profiling the transcriptomes of single cells have recently emerged as transformative approaches for large-scale population surveys of cellular diversity in heterogeneous primary tis...

    Authors: Aparna Bhaduri, Tomasz J Nowakowski, Alex A Pollen and Arnold R Kriegstein

    Citation: BMC Biology 2018 16:113

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  2. Content type: Research article

    Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addi...

    Authors: Rebecca E. W. Kaplan, Amy K. Webster, Rojin Chitrakar, Joseph A. Dent and L. Ryan Baugh

    Citation: BMC Biology 2018 16:112

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  3. Content type: Research article

    H3.3 is an ancient and conserved H3 variant and plays essential roles in transcriptional regulation. HIRA complex, which is composed of HIRA, UBN1 or UBN2, and Cabin1, is a H3.3 specific chaperone complex. How...

    Authors: Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu and Guohong Li

    Citation: BMC Biology 2018 16:110

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  4. Content type: Research article

    The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the p...

    Authors: Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis…

    Citation: BMC Biology 2018 16:109

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  5. Content type: Research article

    Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an “explosive” organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morpholog...

    Authors: Kartik Sunagar, Yaara Y Columbus-Shenkar, Arie Fridrich, Nadya Gutkovich, Reuven Aharoni and Yehu Moran

    Citation: BMC Biology 2018 16:108

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  6. Content type: Research article

    Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmissio...

    Authors: Mandy Sonntag, Maren Blosa, Sophie Schmidt, Katja Reimann, Kerstin Blum, Tobias Eckrich, Gudrun Seeger, Dietmar Hecker, Bernhard Schick, Thomas Arendt, Jutta Engel and Markus Morawski

    Citation: BMC Biology 2018 16:99

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    The Commentary to this article has been published in BMC Biology 2018 16:105

  7. Content type: Commentary

    During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at ...

    Authors: Thomas M. Coate and Katherine Conant

    Citation: BMC Biology 2018 16:105

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    The original article was published in BMC Biology 2018 16:99

  8. Content type: Research article

    Sexual reproduction is the norm in almost all animal species, and in many advanced animal societies, both males and females participate in social activities. To date, the complete loss of males from advanced s...

    Authors: Toshihisa Yashiro, Nathan Lo, Kazuya Kobayashi, Tomonari Nozaki, Taro Fuchikawa, Nobuaki Mizumoto, Yusuke Namba and Kenji Matsuura

    Citation: BMC Biology 2018 16:96

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    The Commentary to this article has been published in BMC Biology 2018 16:106

  9. Content type: Research article

    The hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z...

    Authors: Yan Wang, Haizhen Long, Juan Yu, Liping Dong, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao, Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qian-fei Wang, Xueqing Xu, Raphael Margueron…

    Citation: BMC Biology 2018 16:107

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  10. Content type: Comment

    CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it c...

    Authors: Eugene V. Koonin

    Citation: BMC Biology 2018 16:95

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  11. Content type: Research article

    Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that re...

    Authors: Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson and Patrick S. Western

    Citation: BMC Biology 2018 16:104

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  12. Content type: Research article

    piRNAs have a constitutive role in genome defence by silencing transposable elements in the germline. In the nematode Caenorhabditis elegans, piRNAs also induce epigenetic silencing of transgenes, which can be ma...

    Authors: Tony Belicard, Pree Jareosettasin and Peter Sarkies

    Citation: BMC Biology 2018 16:103

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  13. Content type: Research article

    Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumen...

    Authors: P. J. Fabre, M. Leleu, B. Mascrez, Q. Lo Giudice, J. Cobb and D. Duboule

    Citation: BMC Biology 2018 16:101

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  14. Content type: Research article

    Two of the most widely cultivated rice strains are Oryza sativa indica and O. sativa japonica, and understanding the genetic basis of their agronomic traits is of importance for crop production. These two species...

    Authors: Xiukun Li, Lian Wu, Jiahong Wang, Jian Sun, Xiuhong Xia, Xin Geng, Xuhong Wang, Zhengjin Xu and Quan Xu

    Citation: BMC Biology 2018 16:102

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  15. Content type: Question and Answer

    Array tomography encompasses light and electron microscopy modalities that offer unparalleled opportunities to explore three-dimensional cellular architectures in extremely fine structural and molecular detail...

    Authors: Stephen J Smith

    Citation: BMC Biology 2018 16:98

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  16. Content type: Research article

    Biologists have long been fascinated by the striking diversity of complex color patterns in tropical reef fishes. However, the origins and evolution of this diversity are still poorly understood. Disentangling...

    Authors: Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich

    Citation: BMC Biology 2018 16:90

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  17. Content type: Research article

    Proteins within the cytoplasmic membrane display distinct localization patterns and arrangements. While multiple models exist describing the dynamics of membrane proteins, to date, there have been few systemat...

    Authors: Daniella Lucena, Marco Mauri, Felix Schmidt, Bruno Eckhardt and Peter L. Graumann

    Citation: BMC Biology 2018 16:97

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  18. Content type: Review

    Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimen...

    Authors: Thomas Flatt and Linda Partridge

    Citation: BMC Biology 2018 16:93

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  19. Content type: Comment

    Seventeen years after the initial publication of the human genome, we still haven’t found all of our genes. The answer turns out to be more complex than anyone had imagined when the Human Genome Project began.

    Authors: Steven L. Salzberg

    Citation: BMC Biology 2018 16:94

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  20. Content type: Research article

    Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activ...

    Authors: Tomer Shlamkovich, Lidan Aharon, Dana Koslawsky, Yulia Einav and Niv Papo

    Citation: BMC Biology 2018 16:92

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  21. Content type: Research article

    Our understanding of the regulation of gene expression has benefited from the availability of high-throughput technologies that interrogate the whole genome for the binding of specific transcription factors an...

    Authors: Alberto Santos-Zavaleta, Mishael Sánchez-Pérez, Heladia Salgado, David A. Velázquez-Ramírez, Socorro Gama-Castro, Víctor H. Tierrafría, Stephen J. W. Busby, Patricia Aquino, Xin Fang, Bernhard O. Palsson, James E. Galagan and Julio Collado-Vides

    Citation: BMC Biology 2018 16:91

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  22. Content type: Research article

    Division of labor between reproductive queens and workers that perform brood care is a hallmark of insect societies. However, studies of the molecular basis of this fundamental dichotomy are limited by the fac...

    Authors: Romain Libbrecht, Peter R. Oxley and Daniel J. C. Kronauer

    Citation: BMC Biology 2018 16:89

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  23. Content type: Methodology article

    The ubiquitin-proteasome system (UPS) controls the stability, localization and/or activity of the proteome. However, the identification and characterization of complex individual ubiquitination cascades and th...

    Authors: Joanna Koszela, Nhan T. Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F. J. Ceccarelli, Frank Sicheri, Mike Tyers and Manfred Auer

    Citation: BMC Biology 2018 16:88

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  24. Content type: Research article

    The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribu...

    Authors: Jan Krefting, Miguel A. Andrade-Navarro and Jonas Ibn-Salem

    Citation: BMC Biology 2018 16:87

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  25. Content type: Research article

    The timing of action potentials (“spikes”) of cortical neurons has been shown to be aligned to the phase of low-frequency (< 10 Hz) local field potentials (LFPs) in several cortical areas. However, across the ...

    Authors: Moein Esghaei, Mohammad Reza Daliri and Stefan Treue

    Citation: BMC Biology 2018 16:86

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  26. Content type: Research article

    Membrane lipids play critical roles in the structure and function of membrane-embedded transporters. Salmonella typhimurium MelB (MelBSt) is a symporter coupling melibiose translocation with a cation (Na+, Li+, o...

    Authors: Parameswaran Hariharan, Elena Tikhonova, João Medeiros-Silva, Aike Jeucken, Mikhail V. Bogdanov, William Dowhan, Jos F. Brouwers, Markus Weingarth and Lan Guan

    Citation: BMC Biology 2018 16:85

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  27. Content type: Research article

    Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gas...

    Authors: Elvire Berthenet, Koji Yahara, Kaisa Thorell, Ben Pascoe, Guillaume Meric, Jane M. Mikhail, Lars Engstrand, Helena Enroth, Alain Burette, Francis Megraud, Christine Varon, John C Atherton, Sinead Smith, Thomas S. Wilkinson, Matthew D. Hitchings, Daniel Falush…

    Citation: BMC Biology 2018 16:84

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  28. Content type: Research article

    Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, ...

    Authors: Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt and Alessandro Ori

    Citation: BMC Biology 2018 16:82

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  29. Content type: Research article

    Naked mole-rats (NMRs) are eusocially organized in colonies. Although breeders carry the additional metabolic load of reproduction, they are extremely long-lived and remain fertile throughout their lifespan. T...

    Authors: Martin Bens, Karol Szafranski, Susanne Holtze, Arne Sahm, Marco Groth, Hans A. Kestler, Thomas B. Hildebrandt and Matthias Platzer

    Citation: BMC Biology 2018 16:77

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  30. Content type: Research article

    The interaction between oomycete plant pathogen Phytophthora sojae and soybean is characterized by the presence of avirulence (Avr) genes in P. sojae, which encode for effectors that trigger immune responses and ...

    Authors: Geneviève Arsenault-Labrecque, Humira Sonah, Amandine Lebreton, Caroline Labbé, Geneviève Marchand, Allen Xue, François Belzile, Brian J. Knaus, Niklaus J. Grünwald and Richard R. Bélanger

    Citation: BMC Biology 2018 16:80

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  31. Content type: Research article

    Fungal plant pathogens pose major threats to crop yield and sustainable food production if they are highly adapted to their host and the local environment. Variation in gene expression contributes to phenotypi...

    Authors: Parvathy Krishnan, Lukas Meile, Clémence Plissonneau, Xin Ma, Fanny E. Hartmann, Daniel Croll, Bruce A. McDonald and Andrea Sánchez-Vallet

    Citation: BMC Biology 2018 16:78

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  32. Content type: Research article

    Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are c...

    Authors: Santiago Martínez-Lumbreras, Ewelina M. Krysztofinska, Arjun Thapaliya, Alessandro Spilotros, Dijana Matak-Vinkovic, Enrico Salvadori, Peristera Roboti, Yvonne Nyathi, Janina H. Muench, Maxie M. Roessler, Dmitri I. Svergun, Stephen High and Rivka L. Isaacson

    Citation: BMC Biology 2018 16:76

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  33. Content type: Research article

    RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies ...

    Authors: Pavitra Roychoudhury, Harshana De Silva Feelixge, Daniel Reeves, Bryan T. Mayer, Daniel Stone, Joshua T. Schiffer and Keith R. Jerome

    Citation: BMC Biology 2018 16:75

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  34. Content type: Research article

    In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated activation of primordial follicles leads to v...

    Authors: Hao Yan, Jiawei Zhang, Jia Wen, Yibo Wang, Wanbao Niu, Zhen Teng, Tongtong Zhao, Yanli Dai, Yan Zhang, Chao Wang, Yingying Qin, Guoliang Xia and Hua Zhang

    Citation: BMC Biology 2018 16:73

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  35. Content type: Research article

    The phenotypes of sperm are generally believed to be under the control of the diploid genotype of the male producing them rather than their own haploid genotypes, because developing spermatids share cytoplasm ...

    Authors: Richard Borowsky, Alissa Luk, Xinjian He and Rebecca S. Kim

    Citation: BMC Biology 2018 16:72

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  36. Content type: Research article

    Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs display a vast array of phenotypes that differ from their ancestors, yet mirror other domesticated animal species, a phenomenon known as the...

    Authors: Amanda L. Pendleton, Feichen Shen, Angela M. Taravella, Sarah Emery, Krishna R. Veeramah, Adam R. Boyko and Jeffrey M. Kidd

    Citation: BMC Biology 2018 16:64

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  37. Content type: Methodology article

    Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT ...

    Authors: Mandi E. Schmidt, Caodu Buren, James P. Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A. Raymond and Michael R. Hayden

    Citation: BMC Biology 2018 16:58

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  38. Content type: Research article

    The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple...

    Authors: Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop and Agnieszka Chacinska

    Citation: BMC Biology 2018 16:66

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    The Commentary to this article has been published in BMC Biology 2018 16:63

  39. Content type: Commentary

    Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al. f...

    Authors: Eva Zöller, R. Todd Alexander and Johannes M. Herrmann

    Citation: BMC Biology 2018 16:63

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    The original article was published in BMC Biology 2018 16:66

  40. Content type: Research article

    The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene–phenotype associations. While CRISPR/Cas...

    Authors: Denise G. Lanza, Angelina Gaspero, Isabel Lorenzo, Lan Liao, Ping Zheng, Ying Wang, Yu Deng, Chonghui Cheng, Chuansheng Zhang, John R. Seavitt, Francesco J. DeMayo, Jianming Xu, Mary E. Dickinson, Arthur L. Beaudet and Jason D. Heaney

    Citation: BMC Biology 2018 16:69

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  41. Content type: Research article

    Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for ge...

    Authors: Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon…

    Citation: BMC Biology 2018 16:70

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  42. Content type: Research article

    To prevent folate deficiencies, many countries supplement various foodstuffs with folic acid. This compound is a synthetic oxidised folate that differs from naturally occurring reduced folates in its metabolis...

    Authors: Claire Maynard, Ian Cummins, Jacalyn Green and David Weinkove

    Citation: BMC Biology 2018 16:67

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  43. Content type: Research article

    S2 cells are one of the most widely used Drosophila melanogaster cell lines. A series of studies has shown that they are particularly suitable for RNAi-based screens aimed at the dissection of cellular pathways, ...

    Authors: Anton Strunov, Lidiya V. Boldyreva, Evgeniya N. Andreyeva, Gera A. Pavlova, Julia V. Popova, Alena V. Razuvaeva, Alina F. Anders, Fioranna Renda, Alexey V. Pindyurin, Maurizio Gatti and Elena Kiseleva

    Citation: BMC Biology 2018 16:68

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