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  1. Content type: Research article

    Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embe...

    Authors: Sunjoo Joo, Ming Hsiu Wang, Gary Lui, Jenny Lee, Andrew Barnas, Eunsoo Kim, Sebastian Sudek, Alexandra Z. Worden and Jae-Hyeok Lee

    Citation: BMC Biology 2018 16:136

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  2. Content type: Interview

    Joel Dacks is an Associate Professor and Canada Research Chair in Evolutionary Cell Biology at the University of Alberta, a Scientific Associate at the Natural History Museum (London), and the current Presiden...

    Authors: Joel B. Dacks

    Citation: BMC Biology 2018 16:119

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  3. Content type: Correction

    Reinvestigation of the raw data revealed an unfortunate error in Ugelvig et al. 2008 [1].

    Authors: Line V. Ugelvig, Falko P. Drijfhout, Daniel J. C. Kronauer, Jacobus J. Boomsma, Jes S. Pedersen and Sylvia Cremer

    Citation: BMC Biology 2018 16:128

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    The original article was published in BMC Biology 2008 6:11

  4. Content type: Research article

    Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimate...

    Authors: Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, Julio Mateos-Langerak, Chantal Cazevieille, Patricia Cavelier, Brigitte Boizet-Bonhoure, Claude Delsert and Nathalie Morin

    Citation: BMC Biology 2018 16:116

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  5. Content type: Research article

    High throughput methods for profiling the transcriptomes of single cells have recently emerged as transformative approaches for large-scale population surveys of cellular diversity in heterogeneous primary tis...

    Authors: Aparna Bhaduri, Tomasz J Nowakowski, Alex A Pollen and Arnold R Kriegstein

    Citation: BMC Biology 2018 16:113

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  6. Content type: Research article

    Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addi...

    Authors: Rebecca E. W. Kaplan, Amy K. Webster, Rojin Chitrakar, Joseph A. Dent and L. Ryan Baugh

    Citation: BMC Biology 2018 16:112

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  7. Content type: Research article

    H3.3 is an ancient and conserved H3 variant and plays essential roles in transcriptional regulation. HIRA complex, which is composed of HIRA, UBN1 or UBN2, and Cabin1, is a H3.3 specific chaperone complex. How...

    Authors: Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu and Guohong Li

    Citation: BMC Biology 2018 16:110

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  8. Content type: Research article

    The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the p...

    Authors: Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis…

    Citation: BMC Biology 2018 16:109

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  9. Content type: Research article

    Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an “explosive” organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morpholog...

    Authors: Kartik Sunagar, Yaara Y Columbus-Shenkar, Arie Fridrich, Nadya Gutkovich, Reuven Aharoni and Yehu Moran

    Citation: BMC Biology 2018 16:108

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  10. Content type: Commentary

    During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at ...

    Authors: Thomas M. Coate and Katherine Conant

    Citation: BMC Biology 2018 16:105

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    The original article was published in BMC Biology 2018 16:99

  11. Content type: Research article

    Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmissio...

    Authors: Mandy Sonntag, Maren Blosa, Sophie Schmidt, Katja Reimann, Kerstin Blum, Tobias Eckrich, Gudrun Seeger, Dietmar Hecker, Bernhard Schick, Thomas Arendt, Jutta Engel and Markus Morawski

    Citation: BMC Biology 2018 16:99

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    The Commentary to this article has been published in BMC Biology 2018 16:105

  12. Content type: Research article

    Sexual reproduction is the norm in almost all animal species, and in many advanced animal societies, both males and females participate in social activities. To date, the complete loss of males from advanced s...

    Authors: Toshihisa Yashiro, Nathan Lo, Kazuya Kobayashi, Tomonari Nozaki, Taro Fuchikawa, Nobuaki Mizumoto, Yusuke Namba and Kenji Matsuura

    Citation: BMC Biology 2018 16:96

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    The Commentary to this article has been published in BMC Biology 2018 16:106

  13. Content type: Research article

    The hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z...

    Authors: Yan Wang, Haizhen Long, Juan Yu, Liping Dong, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao, Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qian-fei Wang, Xueqing Xu, Raphael Margueron…

    Citation: BMC Biology 2018 16:107

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  14. Content type: Comment

    CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it c...

    Authors: Eugene V. Koonin

    Citation: BMC Biology 2018 16:95

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  15. Content type: Research article

    Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that re...

    Authors: Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson and Patrick S. Western

    Citation: BMC Biology 2018 16:104

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  16. Content type: Research article

    piRNAs have a constitutive role in genome defence by silencing transposable elements in the germline. In the nematode Caenorhabditis elegans, piRNAs also induce epigenetic silencing of transgenes, which can be ma...

    Authors: Tony Belicard, Pree Jareosettasin and Peter Sarkies

    Citation: BMC Biology 2018 16:103

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  17. Content type: Research article

    Two of the most widely cultivated rice strains are Oryza sativa indica and O. sativa japonica, and understanding the genetic basis of their agronomic traits is of importance for crop production. These two species...

    Authors: Xiukun Li, Lian Wu, Jiahong Wang, Jian Sun, Xiuhong Xia, Xin Geng, Xuhong Wang, Zhengjin Xu and Quan Xu

    Citation: BMC Biology 2018 16:102

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  18. Content type: Research article

    Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumen...

    Authors: P. J. Fabre, M. Leleu, B. Mascrez, Q. Lo Giudice, J. Cobb and D. Duboule

    Citation: BMC Biology 2018 16:101

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  19. Content type: Question and Answer

    Array tomography encompasses light and electron microscopy modalities that offer unparalleled opportunities to explore three-dimensional cellular architectures in extremely fine structural and molecular detail...

    Authors: Stephen J Smith

    Citation: BMC Biology 2018 16:98

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  20. Content type: Research article

    Biologists have long been fascinated by the striking diversity of complex color patterns in tropical reef fishes. However, the origins and evolution of this diversity are still poorly understood. Disentangling...

    Authors: Pauline Salis, Natacha Roux, Olivier Soulat, David Lecchini, Vincent Laudet and Bruno Frédérich

    Citation: BMC Biology 2018 16:90

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  21. Content type: Research article

    Proteins within the cytoplasmic membrane display distinct localization patterns and arrangements. While multiple models exist describing the dynamics of membrane proteins, to date, there have been few systemat...

    Authors: Daniella Lucena, Marco Mauri, Felix Schmidt, Bruno Eckhardt and Peter L. Graumann

    Citation: BMC Biology 2018 16:97

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  22. Content type: Comment

    Seventeen years after the initial publication of the human genome, we still haven’t found all of our genes. The answer turns out to be more complex than anyone had imagined when the Human Genome Project began.

    Authors: Steven L. Salzberg

    Citation: BMC Biology 2018 16:94

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  23. Content type: Review

    Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimen...

    Authors: Thomas Flatt and Linda Partridge

    Citation: BMC Biology 2018 16:93

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  24. Content type: Research article

    Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activ...

    Authors: Tomer Shlamkovich, Lidan Aharon, Dana Koslawsky, Yulia Einav and Niv Papo

    Citation: BMC Biology 2018 16:92

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  25. Content type: Research article

    Our understanding of the regulation of gene expression has benefited from the availability of high-throughput technologies that interrogate the whole genome for the binding of specific transcription factors an...

    Authors: Alberto Santos-Zavaleta, Mishael Sánchez-Pérez, Heladia Salgado, David A. Velázquez-Ramírez, Socorro Gama-Castro, Víctor H. Tierrafría, Stephen J. W. Busby, Patricia Aquino, Xin Fang, Bernhard O. Palsson, James E. Galagan and Julio Collado-Vides

    Citation: BMC Biology 2018 16:91

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  26. Content type: Research article

    Division of labor between reproductive queens and workers that perform brood care is a hallmark of insect societies. However, studies of the molecular basis of this fundamental dichotomy are limited by the fac...

    Authors: Romain Libbrecht, Peter R. Oxley and Daniel J. C. Kronauer

    Citation: BMC Biology 2018 16:89

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  27. Content type: Methodology article

    The ubiquitin-proteasome system (UPS) controls the stability, localization and/or activity of the proteome. However, the identification and characterization of complex individual ubiquitination cascades and th...

    Authors: Joanna Koszela, Nhan T. Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F. J. Ceccarelli, Frank Sicheri, Mike Tyers and Manfred Auer

    Citation: BMC Biology 2018 16:88

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  28. Content type: Research article

    The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribu...

    Authors: Jan Krefting, Miguel A. Andrade-Navarro and Jonas Ibn-Salem

    Citation: BMC Biology 2018 16:87

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