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  1. The blood–brain barrier serves as a critical interface between the bloodstream and brain tissue, mainly composed of pericytes, neurons, endothelial cells, and tightly connected basal membranes. It plays a pivo...

    Authors: Zhi-Feng Gu, Yu-Duo Hao, Tian-Yu Wang, Pei-Ling Cai, Yang Zhang, Ke-Jun Deng, Hao Lin and Hao Lv
    Citation: BMC Biology 2024 22:86
  2. Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined by a few transcription factors including GATA3. We previously reported...

    Authors: Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang and Xin-Hai Pei
    Citation: BMC Biology 2024 22:85
  3. Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell proliferation is fueled by a transcriptional reg...

    Authors: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel and Y. Jessie Zhang
    Citation: BMC Biology 2024 22:83
  4. As an endemic shrub of the Qinghai-Tibetan Plateau (QTP), the distribution of Hippophae tibetana Schlecht. ranges between 2800 and 5200 m above sea level. As the most basal branch of the Hippophae genus, H. tibet...

    Authors: Guoyun Zhang, Yating Song, Ning Chen, Jihua Wei, Jianguo Zhang and Caiyun He
    Citation: BMC Biology 2024 22:82
  5. Response to oxidative stress is universal in almost all organisms and the mitochondrial membrane protein, BbOhmm, negatively affects oxidative stress responses and virulence in the insect fungal pathogen, Beauver...

    Authors: Yanze Kan, Zhangjiang He, Nemat O. Keyhani, Ning Li, Shuaishuai Huang, Xin Zhao, Pengfei Liu, Fanqin Zeng, Min Li, Zhibing Luo and Yongjun Zhang
    Citation: BMC Biology 2024 22:81
  6. The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compa...

    Authors: Yaxin Cao, Hengyu Yan, Minghao Sheng, Yue Liu, Xinyue Yu, Zhongqiu Li, Wenying Xu and Zhen Su
    Citation: BMC Biology 2024 22:80
  7. Throughout its nearly four-billion-year history, life has undergone evolutionary transitions in which simpler subunits have become integrated to form a more complex whole. Many of these transitions opened the ...

    Authors: Charles Ross Lindsey, Andrew H. Knoll, Matthew D. Herron and Frank Rosenzweig
    Citation: BMC Biology 2024 22:79
  8. Regulation of transcription is central to the emergence of new cell types during development, and it often involves activation of genes via proximal and distal regulatory regions. The activity of regulatory el...

    Authors: Irina Abnizova, Carine Stapel, Rene te Boekhorst, Jimmy Tsz Hang Lee and Martin Hemberg
    Citation: BMC Biology 2024 22:78
  9. Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of ...

    Authors: Jone Marita Kvam, Maja Lind Nybo, Lola Torz, Riia Karolina Sustarsic, Kristian Høj Reveles Jensen, John Erik Nielsen, Hanne Frederiksen, Sarina Gadgaard, Katja Spiess, Steen Seier Poulsen, Jesper Skovhus Thomsen, Pamela Cowin, Martin Blomberg Jensen, Takeshi Kurita and Mette Marie Rosenkilde
    Citation: BMC Biology 2024 22:77
  10. The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely rel...

    Authors: Jinyou Yang, Toma Isaka, Kenji Kikuchi, Keiko Numayama-Tsuruta and Takuji Ishikawa
    Citation: BMC Biology 2024 22:76
  11. Trans-differentiation of human-induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons a likely significant advance for disease model...

    Authors: D. Das, S. Sonthalia, G. Stein-O.’Brien, MH. Wahbeh, K. Feuer, L. Goff, C. Colantuoni, V. Mahairaki and D. Avramopoulos
    Citation: BMC Biology 2024 22:75
  12. The tunicates form a group of filter-feeding marine animals closely related to vertebrates. They share with them a number of features such as a notochord and a dorsal neural tube in the tadpole larvae of ascid...

    Authors: Maxence Lanoizelet, Christel Elkhoury Youhanna, Agnès Roure and Sébastien Darras
    Citation: BMC Biology 2024 22:74
  13. Quorum sensing (QS) is the ability of microorganisms to assess local clonal density by measuring the extracellular concentration of signal molecules that they produce and excrete. QS is also the only known way...

    Authors: Tamás Czárán, István Scheuring, István Zachar and Szabolcs Számadó
    Citation: BMC Biology 2024 22:73
  14. Authors: Caleb C. Vogt, Matthew N. Zipple, Daniel D. Sprockett, Caitlin H. Miller, Summer X. Hardy, Matthew K. Arthur, Adam M. Greenstein, Melanie S. Colvin, Lucie M. Michel, Andrew H. Moeller and Michael J. Sheehan
    Citation: BMC Biology 2024 22:72

    The original article was published in BMC Biology 2024 22:35

  15. Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewi...

    Authors: Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L. Gould, José Cansado and Rafael R. Daga
    Citation: BMC Biology 2024 22:71
  16. Eriophyoid mites (Eriophyoidea) are among the largest groups in the Acariformes; they are strictly phytophagous. The higher-level phylogeny of eriophyoid mites, however, remains unresolved due to the limited n...

    Authors: Qi Zhang, Yi-Wen Lu, Xin-Yu Liu, Ye Li, Wei-Nan Gao, Jing-Tao Sun, Xiao-Yue Hong, Renfu Shao and Xiao-Feng Xue
    Citation: BMC Biology 2024 22:70
  17. Recently, long non-coding RNAs (lncRNAs) have been demonstrated as essential roles in tumor immune microenvironments (TIME). Nevertheless, researches on the clinical significance of TIME-related lncRNAs are li...

    Authors: Yuqing Ren, Ruhao Wu, Chunwei Li, Long Liu, Lifeng Li, Siyuan Weng, Hui Xu, Zhe Xing, Yuyuan Zhang, Libo Wang, Zaoqu Liu and Xinwei Han
    Citation: BMC Biology 2024 22:69
  18. The brown planthopper (BPH) is a kind of piercing-sucking insect specific to rice, with the damage tops the list of pathogens and insects in recent years. microRNAs (miRNAs) are pivotal regulators of plant–env...

    Authors: Bo Sun, Yanjie Shen, Lin Zhu, Xiaofang Yang, Xue Liu, Dayong Li, Mulan Zhu, Xuexia Miao and Zhenying Shi
    Citation: BMC Biology 2024 22:68
  19. Insects have evolved complex visual systems and display an astonishing range of adaptations for diverse ecological niches. Species of Drosophila melanogaster subgroup exhibit extensive intra- and interspecific di...

    Authors: Alexandra D. Buffry, John P. Currea, Franziska A. Franke-Gerth, Ravindra Palavalli-Nettimi, Andrew J. Bodey, Christoph Rau, Nazanin Samadi, Stefan J. Gstöhl, Christian M. Schlepütz, Alistair P. McGregor, Lauren Sumner-Rooney, Jamie Theobald and Maike Kittelmann
    Citation: BMC Biology 2024 22:67
  20. Antibody drug conjugates (ADCs) constitute a promising class of targeted anti-tumor therapeutics that harness the selectivity of monoclonal antibodies with the potency of cytotoxic drugs. ADC development is be...

    Authors: Trevor S. Anderson, Amanda L. McCormick, Savanna L. Smith and Devin B. Lowe
    Citation: BMC Biology 2024 22:66
  21. DNA methylation has been documented to play vital roles in diseases and biological processes. In bovine, little is known about the regulatory roles of DNA methylation alterations on production and health trait...

    Authors: Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Marc-André Sirard and Eveline M. Ibeagha-Awemu
    Citation: BMC Biology 2024 22:65
  22. Obligate blood-feeding insects obtain the nutrients and water necessary to ensure survival from the vertebrate blood. The internal taste sensilla, situated in the pharynx, evaluate the suitability of the inges...

    Authors: Isabel Ortega-Insaurralde, José Manuel Latorre-Estivalis, Andre Luis Costa-da-Silva, Agustina Cano, Teresita C. Insausti, Héctor Salas Morales, Gina Pontes, Martín Berón de Astrada, Sheila Ons, Matthew DeGennaro and Romina B. Barrozo
    Citation: BMC Biology 2024 22:63
  23. Ecosystems are brimming with myriad compounds, including some at very low concentrations that are indispensable for insect survival and reproduction. Screening strategies for identifying active compounds are t...

    Authors: Yipeng Liu, Sai Zhang, Song Cao, Emmanuelle Jacquin-Joly, Qiong Zhou, Yang Liu and Guirong Wang
    Citation: BMC Biology 2024 22:61
  24. Mitochondria participate in various cellular processes including energy metabolism, apoptosis, autophagy, production of reactive oxygen species, stress responses, inflammation and immunity. However, the role o...

    Authors: Laura Vesala, Yuliya Basikhina, Tea Tuomela, Anssi Nurminen, Emilia Siukola, Pedro F. Vale and Tiina S. Salminen
    Citation: BMC Biology 2024 22:60
  25. Hmong–Mien (HM) speakers are linguistically related and live primarily in China, but little is known about their ancestral origins or the evolutionary mechanism shaping their genomic diversity. In particular, ...

    Authors: Yang Gao, Xiaoxi Zhang, Hao Chen, Yan Lu, Sen Ma, Yajun Yang, Menghan Zhang and Shuhua Xu
    Citation: BMC Biology 2024 22:59
  26. Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the dif...

    Authors: Camille Fourneaux, Laëtitia Racine, Catherine Koering, Sébastien Dussurgey, Elodie Vallin, Alice Moussy, Romuald Parmentier, Fanny Brunard, Daniel Stockholm, Laurent Modolo, Franck Picard, Olivier Gandrillon, Andras Paldi and Sandrine Gonin-Giraud
    Citation: BMC Biology 2024 22:58
  27. Authors: Zhikang Hu, Zhengqi Fan, Sijia Li, Minyan Wang, Mingchuan Huang, Xianjin Ma, Weixin Liu, Yupeng Wang, Yifan Yu, Yaxuan Li, Yingkun Sun, Xinlei Li, Jiyuan Li and Hengfu Yin
    Citation: BMC Biology 2024 22:57

    The original article was published in BMC Biology 2024 22:50

  28. RNA-seq is a fundamental technique in genomics, yet reference bias, where transcripts derived from non-reference alleles are quantified less accurately, can undermine the accuracy of RNA-seq quantification and...

    Authors: Benedict Coombes, Thomas Lux, Eduard Akhunov and Anthony Hall
    Citation: BMC Biology 2024 22:56
  29. The underrepresentation of human genomic resources from Southern Chinese populations limited their health equality in the precision medicine era and complete understanding of their genetic formation, admixture...

    Authors: Qiuxia Sun, Mengge Wang, Tao Lu, Shuhan Duan, Yan Liu, Jing Chen, Zhiyong Wang, Yuntao Sun, Xiangping Li, Shaomei Wang, Liuyi Lu, Liping Hu, Libing Yun, Junbao Yang, Jiangwei Yan, Shengjie Nie…
    Citation: BMC Biology 2024 22:55
  30. Gut bacteria are beneficial to the host, many of which must be passed on to host offspring. During metamorphosis, the midgut of holometabolous insects undergoes histolysis and remodeling, and thus risks losing...

    Authors: Pei Xiong, Wen-Wen Wang, Xu-Sheng Liu, Yu-Feng Wang and Jia-Lin Wang
    Citation: BMC Biology 2024 22:54
  31. Plant diseases are driven by an intricate set of defense mechanisms counterbalanced by the expression of host susceptibility factors promoted through the action of pathogen effectors. In spite of their central...

    Authors: Florian Rocher, Samir Dou, Géraldine Philippe, Marie-Laure Martin, Philippe Label, Thierry Langin and Ludovic Bonhomme
    Citation: BMC Biology 2024 22:53
  32. Capsella bursa-pastoris, a cosmopolitan weed of hybrid origin, is an emerging model object for the study of early consequences of polyploidy, being a fast growing annual and a close relative of Arabidopsis thalia...

    Authors: Aleksey A. Penin, Artem S. Kasianov, Anna V. Klepikova, Denis O. Omelchenko, Maksim S. Makarenko and Maria D. Logacheva
    Citation: BMC Biology 2024 22:52
  33. Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the development of the venous vasculature, both at the cellular and molecular levels. Here, we identify a novel role for Sorbs1, the ...

    Authors: Alexandra Veloso, Anouk Bleuart, Louise Conrard, Tanguy Orban, Jonathan Bruyr, Pauline Cabochette, Raoul F. V. Germano, Giel Schevenels, Alice Bernard, Egor Zindy, Sofie Demeyer, Benoit Vanhollebeke, Franck Dequiedt and Maud Martin
    Citation: BMC Biology 2024 22:51
  34. The formation and domestication of ornamental traits are influenced by various aspects, such as the recognition of esthetic values and cultural traditions. Camellia japonica is widely appreciated and domesticated...

    Authors: Zhikang Hu, Zhengqi Fan, Sijia Li, Minyan Wang, Mingchuan Huang, Xianjin Ma, Weixin Liu, Yupeng Wang, Yifan Yu, Yaxuan Li, Yingkun Sun, Xinlei Li, Jiyuan Li and Hengfu Yin
    Citation: BMC Biology 2024 22:50

    The Author Correction to this article has been published in BMC Biology 2024 22:57

  35. Resolving the phylogeny of rapidly radiating lineages presents a challenge when building the Tree of Life. An Old World avian family Prunellidae (Accentors) comprises twelve species that rapidly diversified at...

    Authors: Zhiyong Jiang, Wenqing Zang, Per G. P. Ericson, Gang Song, Shaoyuan Wu, Shaohong Feng, Sergei V. Drovetski, Gang Liu, Dezhi Zhang, Takema Saitoh, Per Alström, Scott V. Edwards, Fumin Lei and Yanhua Qu
    Citation: BMC Biology 2024 22:49
  36. Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. De...

    Authors: Andrea Coschiera, Masahito Yoshihara, Gilbert Lauter, Sini Ezer, Mariangela Pucci, Haonan Li, Alan Kavšek, Christian G. Riedel, Juha Kere and Peter Swoboda
    Citation: BMC Biology 2024 22:48
  37. Crocodilians are one of the oldest extant vertebrate lineages, exhibiting a combination of evolutionary success and morphological resilience that has persisted throughout the history of life on Earth. This abi...

    Authors: Vanessa C. Sales-Oliveira, Rodrigo Zeni dos Santos, Caio Augusto Gomes Goes, Rodrigo Milan Calegari, Manuel A. Garrido-Ramos, Marie Altmanová, Tariq Ezaz, Thomas Liehr, Fabio Porto-Foresti, Ricardo Utsunomia and Marcelo B. Cioffi
    Citation: BMC Biology 2024 22:47
  38. Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The ass...

    Authors: Troy A. Kervin and Michael Overduin
    Citation: BMC Biology 2024 22:46
  39. Most disease resistance (R) genes in plants encode proteins that contain leucine-rich-repeat (LRR) and nucleotide-binding site (NBS) domains, which belong to the NBS-LRR family. The sequenced genomes of Fusarium ...

    Authors: Yunpeng Cao, Wanzhen Mo, Yanli Li, Yao Xiong, Han Wang, Yingjie Zhang, Mengfei Lin, Lin Zhang and Xiaoxu Li
    Citation: BMC Biology 2024 22:45
  40. Circular RNAs (circRNAs) can regulate microRNA activity and are related to various diseases, such as cancer. Functional research on circRNAs is the focus of scientific research. Accurate identification of circ...

    Authors: Mengting Niu, Chunyu Wang, Yaojia Chen, Quan Zou, Ren Qi and Lei Xu
    Citation: BMC Biology 2024 22:44
  41. High tumor mutational burden (TMB) was reported to predict the efficacy of immune checkpoint inhibitors (ICIs). Pembrolizumab, an anti-PD-1, received FDA-approval for the treatment of unresectable/metastatic t...

    Authors: Célia Dupain, Tom Gutman, Elodie Girard, Choumouss Kamoun, Grégoire Marret, Zahra Castel-Ajgal, Marie-Paule Sablin, Cindy Neuzillet, Edith Borcoman, Ségolène Hescot, Céline Callens, Olfa Trabelsi-Grati, Samia Melaabi, Roseline Vibert, Samantha Antonio, Coralie Franck…
    Citation: BMC Biology 2024 22:43
  42. The adaptive mechanisms of agricultural pests are the key to understanding the evolution of the pests and to developing new control strategies. However, there are few studies on the genetic basis of adaptation...

    Authors: Ping Wang, Minghui Jin, Chao Wu, Yan Peng, Yanjin He, Hanyue Wang and Yutao Xiao
    Citation: BMC Biology 2024 22:42
  43. Prior to soil formation, phosphate liberated by rock weathering is often sequestered into highly insoluble lanthanide phosphate minerals. Dissolution of these minerals releases phosphate and lanthanides to the...

    Authors: Marcos Y. Voutsinos, Jacob A. West-Roberts, Rohan Sachdeva, John W. Moreau and Jillian F. Banfield
    Citation: BMC Biology 2024 22:41
  44. Threshold-dependent gene drives (TDGDs) could be used to spread desirable traits through a population, and are likely to be less invasive and easier to control than threshold-independent gene drives. Engineere...

    Authors: Anna Janzen, Ratnasri Pothula, Adam Sychla, Nathan R. Feltman and Michael J. Smanski
    Citation: BMC Biology 2024 22:40
  45. Surrogate production by germline stem cell transplantation is a powerful method to produce donor-derived gametes via a host, a practice known as surrogacy. The gametes produced by surrogates are often analysed...

    Authors: Rigolin Nayak, Roman Franěk, Audrey Laurent and Martin Pšenička
    Citation: BMC Biology 2024 22:39
  46. Plants have complex and dynamic immune systems that have evolved to resist pathogens. Humans have worked to enhance these defenses in crops through breeding. However, many crops harbor only a fraction of the g...

    Authors: Noah P. Winters, Eric K. Wafula, Benjamin J. Knollenberg, Tuomas Hämälä, Prakash R. Timilsena, Melanie Perryman, Dapeng Zhang, Lena L. Sheaffer, Craig A. Praul, Paula E. Ralph, Sarah Prewitt, Mariela E. Leandro-Muñoz, Diego A. Delgadillo-Duran, Naomi S. Altman, Peter Tiffin, Siela N. Maximova…
    Citation: BMC Biology 2024 22:38
  47. In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection...

    Authors: Alfa Dhakal, Chinnu Salim, Mary Skelly, Yarden Amichan, Ayelet T. Lamm and Heather A. Hundley
    Citation: BMC Biology 2024 22:37
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