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  1. Content type: Research article

    Mammalian small intestinal tight junctions (TJ) link epithelial cells to one another and function as a permselective barrier, strictly modulating the passage of ions and macromolecules through the pore and lea...

    Authors: Sarah C. Pearce, Arwa Al-Jawadi, Kunihiro Kishida, Shiyan Yu, Madeleine Hu, Luke F. Fritzky, Karen L. Edelblum, Nan Gao and Ronaldo P. Ferraris

    Citation: BMC Biology 2018 16:19

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  2. Content type: Research article

    Environmental stressors induce changes in endocrine state, leading to energy re-allocation from reproduction to survival. Female Drosophila melanogaster respond to thermal and nutrient stressors by arresting egg ...

    Authors: Matthew R. Meiselman, Timothy G. Kingan and Michael E. Adams

    Citation: BMC Biology 2018 16:18

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  3. Content type: Question and Answer

    Caenorhabditis elegans neurons have recently been found to throw out cellular debris for remote degradation and/or storage, adding an “extracellular garbage elimination” option to known intracellular protein and ...

    Authors: Meghan Lee Arnold, Ilija Melentijevic, Anna Joelle Smart and Monica Driscoll

    Citation: BMC Biology 2018 16:17

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  4. Content type: Research article

    Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-function...

    Authors: Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloé Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen and Amaury Herpin

    Citation: BMC Biology 2018 16:16

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  5. Content type: Research article

    Polyploidization is one of the major evolutionary processes that shape eukaryotic genomes, being particularly common in plants. Polyploids can arise through direct genome doubling within a species (autopolyplo...

    Authors: Irene Julca, Marina Marcet-Houben, Pablo Vargas and Toni Gabaldón

    Citation: BMC Biology 2018 16:15

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  6. Content type: Research article

    The bone morphogenetic protein (BMP) signaling gradient is central for dorsoventral patterning in amphibian embryos. This gradient is established through the interaction of several BMPs and BMP antagonists and...

    Authors: Avi Leibovich, Hadas Kot-Leibovich, Danny Ben-Zvi and Abraham Fainsod

    Citation: BMC Biology 2018 16:13

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  7. Content type: Research article

    The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only b...

    Authors: Fabian Moine, Julien Brechbühl, Monique Nenniger Tosato, Manon Beaumann and Marie-Christine Broillet

    Citation: BMC Biology 2018 16:12

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  8. Content type: Review

    Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—su...

    Authors: Elizabeth A. Craig

    Citation: BMC Biology 2018 16:11

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  9. Content type: Research article

    Genetically encoded calcium ion (Ca2+) indicators (GECIs) are indispensable tools for measuring Ca2+ dynamics and neuronal activities in vitro and in vivo. Red fluorescent protein (RFP)-based GECIs have inherent ...

    Authors: Yi Shen, Hod Dana, Ahmed S. Abdelfattah, Ronak Patel, Jamien Shea, Rosana S. Molina, Bijal Rawal, Vladimir Rancic, Yu-Fen Chang, Lanshi Wu, Yingche Chen, Yong Qian, Matthew D. Wiens, Nathan Hambleton, Klaus Ballanyi, Thomas E. Hughes…

    Citation: BMC Biology 2018 16:9

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  10. Content type: Research article

    Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential ...

    Authors: Edward R. Ballister, Jessica Rodgers, Franck Martial and Robert J. Lucas

    Citation: BMC Biology 2018 16:10

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  11. Content type: Methodology article

    Caenorhabditis elegans nematodes are powerful model organisms, yet quantification of visible phenotypes is still often labor-intensive, biased, and error-prone. We developed WorMachine, a three-step MATLAB-based ...

    Authors: Adam Hakim, Yael Mor, Itai Antoine Toker, Amir Levine, Moran Neuhof, Yishai Markovitz and Oded Rechavi

    Citation: BMC Biology 2018 16:8

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  12. Content type: Research Article

    Structural variation contributes substantially to polymorphism within species. Chromosomal rearrangements that impact genes can lead to functional variation among individuals and influence the expression of ph...

    Authors: Clémence Plissonneau, Fanny E. Hartmann and Daniel Croll

    Citation: BMC Biology 2018 16:5

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  13. Content type: Methodology article

    Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA ...

    Authors: David Eccles, Jodie Chandler, Mali Camberis, Bernard Henrissat, Sergey Koren, Graham Le Gros and Jonathan J. Ewbank

    Citation: BMC Biology 2018 16:6

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  14. Content type: Research article

    Nitric oxide (NO) has been highlighted as an important agent in cancer-related events. Although the inducible nitric oxide synthase (iNOS) isoform has received most attention, recent studies in the literature ...

    Authors: Jon Peñarando, Laura M. López-Sánchez, Rafael Mena, Silvia Guil-Luna, Francisco Conde, Vanessa Hernández, Marta Toledano, Victoria Gudiño, Michela Raponi, Caroline Billard, Carlos Villar, César Díaz, José Gómez-Barbadillo, Juan De la Haba-Rodríguez, Kevin Myant, Enrique Aranda…

    Citation: BMC Biology 2018 16:3

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  15. Content type: Research article

    Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocyt...

    Authors: Thomas R. Lerner, Christophe J. Queval, Antony Fearns, Urska Repnik, Gareth Griffiths and Maximiliano G. Gutierrez

    Citation: BMC Biology 2018 16:1

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  16. Content type: Research article

    Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study of chronic morphine-induced adaptation in the brain and its functional significance is of importance to unders...

    Authors: Yanfang Zhao, Junfang Zhang, Hualan Yang, Dongyang Cui, Jiaojiao Song, Qianqian Ma, Wenjie Luan, Bin Lai, Lan Ma, Ming Chen and Ping Zheng

    Citation: BMC Biology 2017 15:128

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  17. Content type: Review

    The trillions of microbes living in the gut—the gut microbiota—play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes de...

    Authors: Emily R. Davenport, Jon G. Sanders, Se Jin Song, Katherine R. Amato, Andrew G. Clark and Rob Knight

    Citation: BMC Biology 2017 15:127

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  18. Content type: Research article

    Host sexual dimorphism is being increasingly recognized to generate strong differences in the outcome of infectious disease, but the mechanisms underlying immunological differences between males and females re...

    Authors: David F. Duneau, Hannah C. Kondolf, Joo Hyun Im, Gerardo A. Ortiz, Christopher Chow, Michael A. Fox, Ana T. Eugénio, J. Revah, Nicolas Buchon and Brian P. Lazzaro

    Citation: BMC Biology 2017 15:124

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  19. Content type: Methodology article

    A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance ...

    Authors: Sarah V. Biedermann, Daniel G. Biedermann, Frederike Wenzlaff, Tim Kurjak, Sawis Nouri, Matthias K. Auer, Klaus Wiedemann, Peer Briken, Jan Haaker, Tina B. Lonsdorf and Johannes Fuss

    Citation: BMC Biology 2017 15:125

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