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  1. Content type: Research article

    To prevent folate deficiencies, many countries supplement various foodstuffs with folic acid. This compound is a synthetic oxidised folate that differs from naturally occurring reduced folates in its metabolis...

    Authors: Claire Maynard, Ian Cummins, Jacalyn Green and David Weinkove

    Citation: BMC Biology 2018 16:67

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  2. Content type: Research article

    Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through in...

    Authors: Florian A. Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann S. Gallot, Aurélie Docquier, Allan F. Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, Béatrice Chabi, Marc Francaux, François Casas, Damien Freyssenet, Jennifer Rieusset, Sophie Giorgetti-Peraldi…

    Citation: BMC Biology 2018 16:65

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  3. Content type: Research article

    Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, fu...

    Authors: Benjamin E. Mead, Jose Ordovas-Montanes, Alexandra P. Braun, Lauren E. Levy, Prerna Bhargava, Matthew J. Szucs, Dustin A. Ammendolia, Melanie A. MacMullan, Xiaolei Yin, Travis K. Hughes, Marc H. Wadsworth II, Rushdy Ahmad, Seth Rakoff-Nahoum, Steven A. Carr, Robert Langer, James J. Collins…

    Citation: BMC Biology 2018 16:62

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  4. Content type: Research article

    Hydrogen peroxide (H2O2) is generated as a by-product of metabolic reactions during oxygen use by aerobic organisms, and can be toxic or participate in signaling processes. Cells, therefore, need to be able to se...

    Authors: Alba Domènech, José Ayté, Fernando Antunes and Elena Hidalgo

    Citation: BMC Biology 2018 16:61

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  5. Content type: Research article

    Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular pr...

    Authors: Jose L. Olmos Jr, Suraj Pandey, Jose M. Martin-Garcia, George Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty…

    Citation: BMC Biology 2018 16:59

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  6. Content type: Research article

    Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpigh...

    Authors: Wenjing Zheng, Florentina Rus, Ana Hernandez, Ping Kang, William Goldman, Neal Silverman and Marc Tatar

    Citation: BMC Biology 2018 16:60

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  7. Content type: Commentary

    A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-...

    Authors: Allen M. Orville

    Citation: BMC Biology 2018 16:55

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  9. Content type: Methodology article

    Advances in tissue clearing and molecular labeling methods are enabling unprecedented optical access to large intact biological systems. These developments fuel the need for high-speed microscopy approaches to...

    Authors: Bianca Migliori, Malika S. Datta, Christophe Dupre, Mehmet C. Apak, Shoh Asano, Ruixuan Gao, Edward S. Boyden, Ola Hermanson, Rafael Yuste and Raju Tomer

    Citation: BMC Biology 2018 16:57

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  10. Content type: Research article

    Trichogrammatids are minute parasitoid wasps that develop within other insect eggs. They are less than half a millimeter long, smaller than some protozoans. The Trichogrammatidae are one of the earliest branch...

    Authors: Amelia R. I. Lindsey, Yogeshwar D. Kelkar, Xin Wu, Dan Sun, Ellen O. Martinson, Zhichao Yan, Paul F. Rugman-Jones, Daniel S. T. Hughes, Shwetha C. Murali, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni…

    Citation: BMC Biology 2018 16:54

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  11. Content type: Research article

    The evolutionary roots of human moral behavior are a key precondition to understanding human nature. Investigations usually start with a social dilemma and end up with a norm that can provide some insight into...

    Authors: J. Garay, S. Számadó, Z. Varga and E. Szathmáry

    Citation: BMC Biology 2018 16:53

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  12. Content type: Research article

    Sequencing-based analyses of low-biomass samples are known to be prone to misinterpretation due to the potential presence of contaminating molecules derived from laboratory reagents and environments. DNA conta...

    Authors: Anna Heintz-Buschart, Dilmurat Yusuf, Anne Kaysen, Alton Etheridge, Joëlle V. Fritz, Patrick May, Carine de Beaufort, Bimal B. Upadhyaya, Anubrata Ghosal, David J. Galas and Paul Wilmes

    Citation: BMC Biology 2018 16:52

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  13. Content type: Research article

    Regulatory T cells (Tregs) expressing the transcription factor FOXP3 are crucial mediators of self-tolerance, preventing autoimmune diseases but possibly hampering tumor rejection. Clinical manipulation of Tre...

    Authors: Angelika Schmidt, Francesco Marabita, Narsis A. Kiani, Catharina C. Gross, Henrik J. Johansson, Szabolcs Éliás, Sini Rautio, Matilda Eriksson, Sunjay Jude Fernandes, Gilad Silberberg, Ubaid Ullah, Urvashi Bhatia, Harri Lähdesmäki, Janne Lehtiö, David Gomez-Cabrero, Heinz Wiendl…

    Citation: BMC Biology 2018 16:47

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  14. Content type: Research article

    Environmental influences fluctuate throughout the life course of an organism. It is therefore important to understand how the timing of exposure impacts molecular responses. Herein, we examine the responses of...

    Authors: Amy F. Danson, Sarah J. Marzi, Robert Lowe, Michelle L. Holland and Vardhman K. Rakyan

    Citation: BMC Biology 2018 16:51

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  15. Content type: Research article

    Photosensitizing fluorescent proteins, which generate reactive oxygen species (ROS) upon light irradiation, are useful for spatiotemporal protein inactivation and cell ablation. They give us clues about protei...

    Authors: Yemima Dani Riani, Tomoki Matsuda, Kiwamu Takemoto and Takeharu Nagai

    Citation: BMC Biology 2018 16:50

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  16. Content type: Research article

    Intron retention (IR), the most prevalent alternative splicing form in plants, plays a critical role in gene expression during plant development and stress response. However, the molecular mechanisms underlyin...

    Authors: Gang Wei, Kunpeng Liu, Ting Shen, Jinlei Shi, Bing Liu, Miao Han, Maolin Peng, Haihui Fu, Yifan Song, Jun Zhu, Aiwu Dong and Ting Ni

    Citation: BMC Biology 2018 16:44

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  17. Content type: Research article

    Reliable recognition of individuals requires phenotypic identity signatures that are both individually distinctive and appropriately stable over time. Individual-specific vocalisations or visual patterning are...

    Authors: Sarah A. Roberts, Mark C. Prescott, Amanda J. Davidson, Lynn McLean, Robert J. Beynon and Jane L. Hurst

    Citation: BMC Biology 2018 16:48

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  18. Content type: Research article

    Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a critical role in this proce...

    Authors: Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang and Jun Yang

    Citation: BMC Biology 2018 16:46

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  20. Content type: Research article

    Fear conditioning is a form of learning essential for animal survival and used as a behavioral paradigm to study the mechanisms of learning and memory. In mammals, the amygdala plays a crucial role in fear con...

    Authors: Pradeep Lal, Hideyuki Tanabe, Maximiliano L. Suster, Deepak Ailani, Yuri Kotani, Akira Muto, Mari Itoh, Miki Iwasaki, Hironori Wada, Emre Yaksi and Koichi Kawakami

    Citation: BMC Biology 2018 16:45

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  21. Content type: Research article

    Oomycetes are a group of filamentous eukaryotic microorganisms that have colonized all terrestrial and oceanic ecosystems, and they include prominent plant pathogens. The Aphanomyces genus is unique in its abilit...

    Authors: Elodie Gaulin, Michiel J. C. Pel, Laurent Camborde, Hélène San-Clemente, Sarah Courbier, Marie-Alexane Dupouy, Juliette Lengellé, Marine Veyssiere, Aurélie Le Ru, Frédéric Grandjean, Richard Cordaux, Bouziane Moumen, Clément Gilbert, Liliana M. Cano, Jean-Marc Aury, Julie Guy…

    Citation: BMC Biology 2018 16:43

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  22. Content type: Research article

    The presence of photoreceptive molecules outside the eye is widespread among animals, yet their functions in the periphery are less well understood. Marine organisms, such as annelid worms, exhibit a ‘shadow r...

    Authors: Thomas Ayers, Hisao Tsukamoto, Martin Gühmann, Vinoth Babu Veedin Rajan and Kristin Tessmar-Raible

    Citation: BMC Biology 2018 16:41

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  24. Content type: Research article

    Conventionally, comparison among amniotes – birds, mammals, and reptiles – has often been approached through analyses of mammals and, for comparison, birds. However, birds are morphologically and physiological...

    Authors: Yuichiro Hara, Miki Takeuchi, Yuka Kageyama, Kaori Tatsumi, Masahiko Hibi, Hiroshi Kiyonari and Shigehiro Kuraku

    Citation: BMC Biology 2018 16:40

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  25. Content type: Research article

    Tunicates are the closest relatives of vertebrates and are widely used as models to study the evolutionary developmental biology of chordates. Their phylogeny, however, remains poorly understood, and to date, ...

    Authors: Frédéric Delsuc, Hervé Philippe, Georgia Tsagkogeorga, Paul Simion, Marie-Ka Tilak, Xavier Turon, Susanna López-Legentil, Jacques Piette, Patrick Lemaire and Emmanuel J. P. Douzery

    Citation: BMC Biology 2018 16:39

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  27. Content type: Review

    Spatial organization of membrane domains within cells and cells within tissues is key to the development of organisms and the maintenance of adult tissue. Cell polarization is crucial for correct cell–cell sig...

    Authors: Ana-Citlali Gradilla, David Sanchez-Hernandez, Lucy Brunt and Steffen Scholpp

    Citation: BMC Biology 2018 16:37

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  28. Content type: Research article

    Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress-sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and dev...

    Authors: Elke Malzer, Caia S. Dominicus, Joseph E. Chambers, Jennifer A. Dickens, Souradip Mookerjee and Stefan J. Marciniak

    Citation: BMC Biology 2018 16:34

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  29. Content type: Methodology article

    Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabdit...

    Authors: Blanca Hernando-Rodríguez, Annmary Paul Erinjeri, María Jesús Rodríguez-Palero, Val Millar, Sara González-Hernández, María Olmedo, Bettina Schulze, Ralf Baumeister, Manuel J. Muñoz, Peter Askjaer and Marta Artal-Sanz

    Citation: BMC Biology 2018 16:36

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  30. Content type: Correction

    Upon publication of the original article, Barlow et al. [1], the authors noticed that Fig. 4b contained an inaccuracy when additional data is taken into account. We inferred a loss of GRASP in the common ances...

    Authors: Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks

    Citation: BMC Biology 2018 16:35

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    The original article was published in BMC Biology 2018 16:27

  31. Content type: Research article

    The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease...

    Authors: Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel and Sonia M. Brichard

    Citation: BMC Biology 2018 16:33

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  33. Content type: Research article

    Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that ...

    Authors: Asghar M. Razavi, George Khelashvili and Harel Weinstein

    Citation: BMC Biology 2018 16:31

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  34. Content type: Research article

    Eukaryotes evolved from the symbiotic association of at least two prokaryotic partners, and a good deal is known about the timings, mechanisms, and dynamics of these evolutionary steps. Recently, it was shown ...

    Authors: Raphaël Méheust, Debashish Bhattacharya, Jananan S. Pathmanathan, James O. McInerney, Philippe Lopez and Eric Bapteste

    Citation: BMC Biology 2018 16:30

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  35. Content type: Research article

    The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle’s dysfunction results in human disease. Its characteristic morphology of multiple di...

    Authors: Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks

    Citation: BMC Biology 2018 16:27

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    The Correction to this article has been published in BMC Biology 2018 16:35

  36. Content type: Research article

    Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects...

    Authors: Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn and Anne J. Ridley

    Citation: BMC Biology 2018 16:29

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  37. Content type: Software

    Multiple RNA samples are frequently processed together and often mixed before multiplex sequencing in the same sequencing run. While different samples can be separated post sequencing using sample barcodes, th...

    Authors: Paul Simion, Khalid Belkhir, Clémentine François, Julien Veyssier, Jochen C. Rink, Michaël Manuel, Hervé Philippe and Maximilian J. Telford

    Citation: BMC Biology 2018 16:28

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  38. Content type: Research article

    Associations between traits are prevalent in nature, occurring across a diverse range of taxa and traits. Individual traits may co-evolve with one other, and these correlations can be driven by factors intrins...

    Authors: Dana A. Opulente, Emily J. Rollinson, Cleome Bernick-Roehr, Amanda Beth Hulfachor, Antonis Rokas, Cletus P. Kurtzman and Chris Todd Hittinger

    Citation: BMC Biology 2018 16:26

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  39. Content type: Research article

    G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (...

    Authors: Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick and Rafael Franco

    Citation: BMC Biology 2018 16:24

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  40. Content type: Methodology article

    The ability to efficiently visualize and manipulate chromosomes is fundamental to understanding the genome architecture of organisms. Conventional chromosome preparation protocols developed for mammalian cells...

    Authors: Longhua Guo, Alice Accorsi, Shuonan He, Carlos Guerrero-Hernández, Shamilene Sivagnanam, Sean McKinney, Matthew Gibson and Alejandro Sánchez Alvarado

    Citation: BMC Biology 2018 16:25

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  41. Content type: Review

    The need for high-throughput, precise, and meaningful methods for measuring behavior has been amplified by our recent successes in measuring and manipulating neural circuitry. The largest challenges associated...

    Authors: Gordon J. Berman

    Citation: BMC Biology 2018 16:23

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  42. Content type: Review

    Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging ...

    Authors: Mel Greaves

    Citation: BMC Biology 2018 16:22

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  44. Content type: Research article

    In plants, the shoot apical meristem (SAM) has two main functions, involving the production of all aerial organs on the one hand and self-maintenance on the other, allowing the production of organs during the ...

    Authors: Thomas Stanislas, Matthieu Pierre Platre, Mengying Liu, Léa E. S. Rambaud-Lavigne, Yvon Jaillais and Olivier Hamant

    Citation: BMC Biology 2018 16:20

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  45. Content type: Research article

    Mammalian small intestinal tight junctions (TJ) link epithelial cells to one another and function as a permselective barrier, strictly modulating the passage of ions and macromolecules through the pore and lea...

    Authors: Sarah C. Pearce, Arwa Al-Jawadi, Kunihiro Kishida, Shiyan Yu, Madeleine Hu, Luke F. Fritzky, Karen L. Edelblum, Nan Gao and Ronaldo P. Ferraris

    Citation: BMC Biology 2018 16:19

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  46. Content type: Research article

    Environmental stressors induce changes in endocrine state, leading to energy re-allocation from reproduction to survival. Female Drosophila melanogaster respond to thermal and nutrient stressors by arresting egg ...

    Authors: Matthew R. Meiselman, Timothy G. Kingan and Michael E. Adams

    Citation: BMC Biology 2018 16:18

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  47. Content type: Question and Answer

    Caenorhabditis elegans neurons have recently been found to throw out cellular debris for remote degradation and/or storage, adding an “extracellular garbage elimination” option to known intracellular protein and ...

    Authors: Meghan Lee Arnold, Ilija Melentijevic, Anna Joelle Smart and Monica Driscoll

    Citation: BMC Biology 2018 16:17

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  48. Content type: Research article

    Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-function...

    Authors: Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloé Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen and Amaury Herpin

    Citation: BMC Biology 2018 16:16

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  49. Content type: Research article

    Polyploidization is one of the major evolutionary processes that shape eukaryotic genomes, being particularly common in plants. Polyploids can arise through direct genome doubling within a species (autopolyplo...

    Authors: Irene Julca, Marina Marcet-Houben, Pablo Vargas and Toni Gabaldón

    Citation: BMC Biology 2018 16:15

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