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  1. Relaxed molecular clock models allow divergence time dating and "relaxed phylogenetic" inference, in which a time tree is estimated in the face of unequal rates across lineages. We present a new method for rel...

    Authors: Alexei J Drummond and Marc A Suchard
    Citation: BMC Biology 2010 8:114
  2. Hormones are critical for early gonadal development in nonmammalian vertebrates, and oestrogen is required for normal ovarian development. In contrast, mammals determine sex by the presence or absence of the SRY ...

    Authors: Andrew J Pask, Natalie E Calatayud, Geoff Shaw, William M Wood and Marilyn B Renfree
    Citation: BMC Biology 2010 8:113
  3. Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by ...

    Authors: Lindsey Mork and Blanche Capel
    Citation: BMC Biology 2010 8:110
  4. Human cases of plague (Yersinia pestis) infection originate, ultimately, in the bacterium's wildlife host populations. The epidemiological dynamics of the wildlife reservoir therefore determine the abundance, dis...

    Authors: Kyrre Linné Kausrud, Mike Begon, Tamara Ben Ari, Hildegunn Viljugrein, Jan Esper, Ulf Büntgen, Herwig Leirs, Claudia Junge, Bao Yang, Meixue Yang, Lei Xu and Nils Chr Stenseth
    Citation: BMC Biology 2010 8:112
  5. Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing actinomycete bacteria. One hypothesis sugg...

    Authors: Jörg Barke, Ryan F Seipke, Sabine Grüschow, Darren Heavens, Nizar Drou, Mervyn J Bibb, Rebecca JM Goss, Douglas W Yu and Matthew I Hutchings
    Citation: BMC Biology 2010 8:109
  6. Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carb...

    Authors: Robert A Cross
    Citation: BMC Biology 2010 8:107
  7. CTCF is a versatile zinc finger DNA-binding protein that functions as a highly conserved epigenetic transcriptional regulator. CTCF is known to act as a chromosomal insulator, bind promoter regions, and facili...

    Authors: William A MacDonald, Debashish Menon, Nicholas J Bartlett, G Elizabeth Sperry, Vanya Rasheva, Victoria Meller and Vett K Lloyd
    Citation: BMC Biology 2010 8:105
  8. The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible...

    Authors: Chunhui Hou and Victor G Corces
    Citation: BMC Biology 2010 8:104
  9. The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafi...

    Authors: Christopher W Wilson and Didier YR Stainier
    Citation: BMC Biology 2010 8:102
  10. Whilst parthenogenesis has evolved multiple times from sexual invertebrate and vertebrate lineages, the drivers and consequences of the sex-asex transition remain mostly uncertain. A model by Stouthamer et al. re...

    Authors: Kayla C King and Gregory DD Hurst
    Citation: BMC Biology 2010 8:101
  11. The evolution of multicellular motile organisms from unicellular ancestors required the utilization of previously evolved tactic behavior in a multicellular context. Volvocine green algae are uniquely suited f...

    Authors: Noriko Ueki, Shigeru Matsunaga, Isao Inouye and Armin Hallmann
    Citation: BMC Biology 2010 8:103
  12. Mitochondria are highly dynamic organelles whose morphology and position within the cell is tightly coupled to metabolic function. There is a limited list of essential proteins that regulate mitochondrial morp...

    Authors: Astrid C Schauss, Huiyan Huang, Seok-Yong Choi, Liqun Xu, Sébastien Soubeyrand, Patricia Bilodeau, Rodolfo Zunino, Peter Rippstein, Michael A Frohman and Heidi M McBride
    Citation: BMC Biology 2010 8:100
  13. Several recent papers illustrate the importance of migration and gene flow in molding the patterns of genetic variation observed in humans today. We place the varied demographic processes covered by these term...

    Authors: Murray P Cox and Michael F Hammer
    Citation: BMC Biology 2010 8:98
  14. Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor ...

    Authors: Philipp Alberts and Daniela Rotin
    Citation: BMC Biology 2010 8:94
  15. Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria p...

    Authors: Bridget Penman, Caroline Buckee, Sunetra Gupta and Sean Nee
    Citation: BMC Biology 2010 8:90
  16. Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This...

    Authors: Damien Chaussabel, Virginia Pascual and Jacques Banchereau
    Citation: BMC Biology 2010 8:84
  17. The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan.

    Authors: Kristel Brys, Natascha Castelein, Filip Matthijssens, Jacques R Vanfleteren and Bart P Braeckman
    Citation: BMC Biology 2010 8:91
  18. Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its...

    Authors: Jason W Locasale and Lewis C Cantley
    Citation: BMC Biology 2010 8:88
  19. Reporter genes are widely used in biology and only a limited number are available. We present a new reporter gene for the localization of mammalian cells and transgenic tissues based on detection of the bglA (SYN...

    Authors: Susan C McCutcheon, Ken Jones, Sarah A Cumming, Richard Kemp, Heather Ireland-Zecchini, John C Saunders, Carol A Houghton, Louise A Howard and Douglas J Winton
    Citation: BMC Biology 2010 8:89
  20. The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is though...

    Authors: Craig D Kaplan
    Citation: BMC Biology 2010 8:85
  21. The downstream of tyrosine kinase/docking protein (Dok) adaptor protein family has seven members, Dok1 to Dok7, that act as substrates of multiple receptor tyrosine kinase and non-receptor tyrosine kinase. The...

    Authors: Wei qi Li, Lei Shi, Yuan gang You, Yan hua Gong, Bin Yin, Jian gang Yuan and Xiao zhong Peng
    Citation: BMC Biology 2010 8:86
  22. The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards pertu...

    Authors: Francesca D Ciccarelli
    Citation: BMC Biology 2010 8:74
  23. The Drosophila Male Specific Lethal (MSL) complex contains chromatin modifying enzymes and non-coding roX RNA. It paints the male X at hundreds of bands where it acetylates histone H4 at lysine 16. This epigeneti...

    Authors: Mahalakshmi Prabhakaran and Richard L Kelley
    Citation: BMC Biology 2010 8:80
  24. Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odour...

    Authors: Sarah A Roberts, Deborah M Simpson, Stuart D Armstrong, Amanda J Davidson, Duncan H Robertson, Lynn McLean, Robert J Beynon and Jane L Hurst
    Citation: BMC Biology 2010 8:75
  25. A study in the current issue of BMC Biology has identified a mouse major urinary protein as a pheromone that attracts female mice to male urine marks and induces a learned attraction to the volatile urinary odor ...

    Authors: Peter A Brennan
    Citation: BMC Biology 2010 8:71
  26. Spartin protein is involved in degradation of epidermal growth factor receptor and turnover of lipid droplets and a lack of expression of this protein is responsible for hereditary spastic paraplegia type 20 (...

    Authors: Christopher Hooper, Swamy S Puttamadappa, Zak Loring, Alexander Shekhtman and Joanna C Bakowska
    Citation: BMC Biology 2010 8:72
  27. A recent paper published in BMC Genomics suggests that retrotransposition may be active in the human gut parasite Entamoeba histolytica. This adds to our knowledge of the various types of repetitive elements in p...

    Authors: Christine Clayton
    Citation: BMC Biology 2010 8:64
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