Bellosta P, Gallant P: Myc Function in Drosophila. Genes Cancer. 2010, 1 (6): 542-546. 10.1177/1947601910377490.
Article
PubMed Central
CAS
PubMed
Google Scholar
Grewal SS: Insulin/TOR signaling in growth and homeostasis: a view from the fly world. Int J Biochem Cell Biol. 2009, 41 (5): 1006-1010. 10.1016/j.biocel.2008.10.010.
Article
CAS
PubMed
Google Scholar
Bohni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, Andruss BF, Beckingham K, Hafen E: Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell. 1999, 97 (7): 865-875. 10.1016/S0092-8674(00)80799-0.
Article
CAS
PubMed
Google Scholar
Huang H, Potter CJ, Tao W, Li DM, Brogiolo W, Hafen E, Sun H, Xu T: PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development. 1999, 126 (23): 5365-5372.
CAS
PubMed
Google Scholar
Gao X, Neufeld TP, Pan D: Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev Biol. 2000, 221 (2): 404-418. 10.1006/dbio.2000.9680.
Article
CAS
PubMed
Google Scholar
Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann MP, Hemmings BA, Hafen E: Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science. 2002, 295 (5562): 2088-2091. 10.1126/science.1068094.
Article
CAS
PubMed
Google Scholar
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol. 1997, 7 (4): 261-269. 10.1016/S0960-9822(06)00122-9.
Article
CAS
PubMed
Google Scholar
Xu C, Kim NG, Gumbiner BM: Regulation of protein stability by GSK3 mediated phosphorylation. Cell Cycle. 2009, 8 (24): 4032-4039. 10.4161/cc.8.24.10111.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR: Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 2000, 14 (19): 2501-2514. 10.1101/gad.836800.
Article
PubMed Central
CAS
PubMed
Google Scholar
Galletti M, Riccardo S, Parisi F, Lora C, Saqcena MK, Rivas L, Wong B, Serra A, Serras F, Grifoni D, Pelicci P, Jiang J, Bellosta P: Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Mol Cell Biol. 2009, 29 (12): 3424-3434. 10.1128/MCB.01535-08.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sengupta S, Peterson TR, Sabatini DM: Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 2010, 40 (2): 310-322. 10.1016/j.molcel.2010.09.026.
Article
PubMed Central
CAS
PubMed
Google Scholar
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell. 2002, 10 (3): 457-468. 10.1016/S1097-2765(02)00636-6.
Article
CAS
PubMed
Google Scholar
Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL: Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 2008, 10 (8): 935-945. 10.1038/ncb1753.
Article
PubMed Central
CAS
PubMed
Google Scholar
Inoki K, Ouyang H, Li Y, Guan KL: Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005, 69 (1): 79-100. 10.1128/MMBR.69.1.79-100.2005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N: mTOR, translation initiation and cancer. Oncogene. 2006, 25 (48): 6416-6422. 10.1038/sj.onc.1209888.
Article
CAS
PubMed
Google Scholar
Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M: A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol. 2000, 14 (6): 783-794. 10.1210/me.14.6.783.
Article
CAS
PubMed
Google Scholar
Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, Downes CP, Hafen E, Thomas G: dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol. 2002, 4 (3): 251-255. 10.1038/ncb763.
Article
CAS
PubMed
Google Scholar
Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD: S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006, 24 (2): 185-197. 10.1016/j.molcel.2006.09.019.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gallant P, Shiio Y, Cheng PF, Parkhurst SM, Eisenman RN: Myc and Max homologs in Drosophila. Science. 1996, 274 (5292): 1523-1527. 10.1126/science.274.5292.1523.
Article
CAS
PubMed
Google Scholar
Schreiber-Agus N, Stein D, Chen K, Goltz JS, Stevens L, DePinho RA: Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc Natl Acad Sci USA. 1997, 94 (4): 1235-1240. 10.1073/pnas.94.4.1235.
Article
PubMed Central
CAS
PubMed
Google Scholar
Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LW, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM, Eisenman RN: Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev. 2003, 17 (9): 1101-1114. 10.1101/gad.1066903.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hulf T, Bellosta P, Furrer M, Steiger D, Svensson D, Barbour A, Gallant P: Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Mol Cell Biol. 2005, 25 (9): 3401-3410. 10.1128/MCB.25.9.3401-3410.2005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li L, Edgar BA, Grewal SS: Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biol. 2010, 11: 7-10.1186/1471-2121-11-7.
Article
PubMed Central
PubMed
Google Scholar
Teleman AA, Hietakangas V, Sayadian AC, Cohen SM: Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 2008, 7 (1): 21-32. 10.1016/j.cmet.2007.11.010.
Article
CAS
PubMed
Google Scholar
Benassayag C, Montero L, Colombie N, Gallant P, Cribbs D, Morello D: Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Mol Cell Biol. 2005, 25 (22): 9897-9909. 10.1128/MCB.25.22.9897-9909.2005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Johnston LA, Prober DA, Edgar BA, Eisenman RN, Gallant P: Drosophila myc regulates cellular growth during development. Cell. 1999, 98 (6): 779-790. 10.1016/S0092-8674(00)81512-3.
Article
CAS
PubMed
Google Scholar
Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, Edgar BA, Eisenman RN: dMyc is required for larval growth and endoreplication in Drosophila. Development. 2004, 131 (10): 2317-2327. 10.1242/dev.01108.
Article
CAS
PubMed
Google Scholar
Grewal SS, Li L, Orian A, Eisenman RN, Edgar BA: Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat Cell Biol. 2005, 7 (3): 295-302. 10.1038/ncb1223.
Article
CAS
PubMed
Google Scholar
Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E: Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 2000, 14 (21): 2689-2694. 10.1101/gad.845700.
Article
PubMed Central
CAS
PubMed
Google Scholar
Montagne J, Stewart MJ, Stocker H, Hafen E, Kozma SC, Thomas G: Drosophila S6 kinase: a regulator of cell size. Science. 1999, 285 (5436): 2126-2129. 10.1126/science.285.5436.2126.
Article
CAS
PubMed
Google Scholar
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP: Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 2000, 14 (21): 2712-2724. 10.1101/gad.835000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Prober DA, Edgar BA: Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 2002, 16 (17): 2286-2299. 10.1101/gad.991102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yanagawa S, Lee JS, Haruna T, Oda H, Uemura T, Takeichi M, Ishimoto A: Accumulation of Armadillo induced by Wingless, Dishevelled, and dominant-negative Zeste-White 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells. J Biol Chem. 1997, 272 (40): 25243-25251. 10.1074/jbc.272.40.25243.
Article
CAS
PubMed
Google Scholar
Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K: Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene. 2006, 25 (48): 6361-6372. 10.1038/sj.onc.1209882.
Article
CAS
PubMed
Google Scholar
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA. 2002, 99 (21): 13571-13576. 10.1073/pnas.202476899.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lizcano JM, Alrubaie S, Kieloch A, Deak M, Leevers SJ, Alessi DR: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem J. 2003, 374 (Pt 2): 297-306.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D: Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol. 2003, 5 (6): 578-581. 10.1038/ncb999.
Article
CAS
PubMed
Google Scholar
Brand AH, Manoukian AS, Perrimon N: Ectopic expression in Drosophila. Methods Cell Biol. 1994, 44: 635-654.
Article
CAS
PubMed
Google Scholar
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol. 2003, 5 (6): 559-565. 10.1038/ncb995.
Article
CAS
PubMed
Google Scholar
Rogulja D, Irvine KD: Regulation of cell proliferation by a morphogen gradient. Cell. 2005, 123 (3): 449-461. 10.1016/j.cell.2005.08.030.
Article
CAS
PubMed
Google Scholar
Patel PH, Thapar N, Guo L, Martinez M, Maris J, Gau CL, Lengyel JA, Tamanoi F: Drosophila Rheb GTPase is required for cell cycle progression and cell growth. J Cell Sci. 2003, 116 (Pt 17): 3601-3610.
Article
CAS
PubMed
Google Scholar
Herranz H, Perez L, Martin FA, Milan M: A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing. EMBO J. 2008, 27 (11): 1633-1645. 10.1038/emboj.2008.84.
Article
PubMed Central
CAS
PubMed
Google Scholar
Duman-Scheel M, Johnston LA, Du W: Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci USA. 2004, 101 (11): 3857-3862. 10.1073/pnas.0400526101.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hennig KM, Neufeld TP: Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila. Genesis. 2002, 34 (1-2): 107-110. 10.1002/gene.10139.
Article
CAS
PubMed
Google Scholar
Brand AH, Perrimon N: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 1993, 118 (2): 401-415.
CAS
PubMed
Google Scholar
Golic KG: Site-specific recombination between homologous chromosomes in Drosophila. Science. 1991, 252 (5008): 958-961. 10.1126/science.2035025.
Article
CAS
PubMed
Google Scholar
Bellosta P, Hulf T, Balla Diop S, Usseglio F, Pradel J, Aragnol D, Gallant P: Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Proc Natl Acad Sci USA. 2005, 102 (33): 11799-11804. 10.1073/pnas.0408945102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Conover CA, Bale LK: Insulin-like growth factor I induction of c-myc expression in bovine fibroblasts can be blocked by antecedent insulin receptor activation. Exp Cell Res. 1998, 238 (1): 122-127. 10.1006/excr.1997.3815.
Article
CAS
PubMed
Google Scholar
Bravo R, Burckhardt J, Curran T, Muller R: Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes. EMBO J. 1985, 4 (5): 1193-1197.
PubMed Central
CAS
PubMed
Google Scholar
Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP, Thomas G: Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab. 2008, 7 (5): 456-465. 10.1016/j.cmet.2008.03.002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gao X, Pan D: TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 2001, 15 (11): 1383-1392. 10.1101/gad.901101.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ziosi M, Baena-Lopez LA, Grifoni D, Froldi F, Pession A, Garoia F, Trotta V, Bellosta P, Cavicchi S: dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells. PLoS Genet. 2010, 6 (9):
Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik NA, Bellosta P, Strand D, Richardson HE, Grifoni D: The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol. 2010, 8 (1): 33-10.1186/1741-7007-8-33.
Article
PubMed Central
PubMed
Google Scholar
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J: Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol. 2003, 13 (15): 1259-1268. 10.1016/S0960-9822(03)00506-2.
Article
CAS
PubMed
Google Scholar
Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL: Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci USA. 2009, 106 (22): 8923-8928. 10.1073/pnas.0903621106.
Article
PubMed Central
CAS
PubMed
Google Scholar
Leevers SJ, Weinkove D, MacDougall LK, Hafen E, Waterfield MD: The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 1996, 15 (23): 6584-6594.
PubMed Central
CAS
PubMed
Google Scholar
Schwinkendorf D, Gallant P: The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo. Gene. 2009, 436 (1-2): 90-100. 10.1016/j.gene.2009.02.009.
Article
CAS
PubMed
Google Scholar